Mechanistic insights on anserine hydrolyzing activities of human carnosinases

• Published in: Biochimica et biophysica acta. General subjects Vol. 1867; no. 3; p. 130290
• Main Authors: Pandya, Vaibhav Kumar, Shankar, S. Shiva, Sonwane, Babasaheb P., Rajesh, S., Rathore, Rajeshwari, Kumaran, Sangaralingam, Kulkarni, Mahesh J.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.03.2023
• Subjects: Animals; Anserine; Anserine - metabolism; Carnosinase; Carnosine; Carnosine - metabolism; Chromatography, Liquid; Diabetes; Dipeptidases - chemistry; Dipeptidases - metabolism; Humans; LC-MS/MS; Molecular Docking Simulation; Multiple reaction monitoring (MRM); Promiscuity; Tandem Mass Spectrometry; LC-MS/MS; Carnosinase; Anserine; Carnosine; Multiple reaction monitoring (MRM); Diabetes; Promiscuity

Anserine and carnosine represent histidine-containing dipeptides that exert a pluripotent protective effect on human physiology. Anserine is known to protect against oxidative stress in diabetes and cardiovascular diseases. Human carnosinases (CN1 and CN2) are dipeptidases involved in the homeostasi...