Expression of Id2 in the developing limb is associated with zones of active BMP signaling and marks the regions of growth and differentiation of the developing digits

• Published in: The International journal of developmental biology Vol. 53; no. 8-10; pp. 1495 - 1502
• Main Authors: Lorda-Diez, Carlos I, Torre-Pérez, Nuria, García-Porrero, Juan A, Hurle, Juan M, Montero, Juan A
• Format: Journal Article
• Language: English
• Published: Spain 2009
• Subjects: Animals; Body Patterning - genetics; Body Patterning - physiology; Bone Morphogenetic Protein 2 - genetics; Bone Morphogenetic Protein 2 - metabolism; Bone Morphogenetic Protein 7 - genetics; Bone Morphogenetic Protein 7 - metabolism; Bone Morphogenetic Proteins - genetics; Bone Morphogenetic Proteins - metabolism; Bone Morphogenetic Proteins - pharmacology; Cartilage - cytology; Cartilage - metabolism; Cell Differentiation - drug effects; Cell Differentiation - genetics; Cell Differentiation - physiology; Cell Proliferation - drug effects; Cells, Cultured; Chick Embryo; Chondrogenesis - drug effects; Extremities - embryology; Gene Expression Regulation, Developmental - drug effects; Immunohistochemistry; In Situ Hybridization; Inhibitor of Differentiation Protein 2 - genetics; Inhibitor of Differentiation Protein 2 - metabolism; Mesoderm - cytology; Mesoderm - metabolism; Microscopy, Confocal; Phosphorylation; Signal Transduction - genetics; Signal Transduction - physiology; Smad1 Protein - metabolism; Smad5 Protein - metabolism; Smad8 Protein - metabolism; Transforming Growth Factor beta - pharmacology

Here we report the pattern of expression of inhibitor of DNA binding/differentiation factor 2 (Id2) in the developing chicken limb. We show that prior to stage 25, Id2 is expressed in the anterior and posterior mesoderm, the AER, and in the early skeletal chondrogenic aggregates. At more advanced st...