Gold nanoparticles reduce tubule-interstitial injury and proteinuria in a murine model of subclinical acute kidney injury

• Published in: Biochimica et biophysica acta. General subjects Vol. 1867; no. 4; p. 130314
• Main Authors: Peres, Rodrigo A.S., Silva-Aguiar, Rodrigo P., Teixeira, Douglas E., Peruchetti, Diogo B., Alves, Sarah A.S., Leal, Anna Beatriz C., Castro, Guilherme F., Ribeiro, Natalia B.S., Guimarães, Fernanda V., Pinheiro, Ana Acacia S., Silva, Patrícia M.R. e, Martins, Marco A., Caruso-Neves, Celso
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.04.2023
• Subjects: Acute Kidney Injury - metabolism; Albumins - metabolism; Animals; Disease Models, Animal; Gold - pharmacology; Gold nanoparticles; Kidney Tubules, Proximal; Low Density Lipoprotein Receptor-Related Protein-2 - metabolism; Metal Nanoparticles; Mice; Proteinuria; Proteinuria - metabolism; Proteinuria - pathology; Proximal tubule; Renal disease; Tubule-interstitial injury; NGAL; MCP-1; PAS; PT; subAKI; PTEC; Renal disease; AuNP; UPCr; KIM-1; Proximal tubule; BSA; DMEM; LDH; FITC; IFN-γ; FBS; TGF-β; BUN; TEMED; CKD; AKI; eGFR; IL; Gold nanoparticles; IP; γ-GT; DAPI; Tubule-interstitial injury; APC; TNF-α; PE; PMSF; Proteinuria

Subclinical acute kidney injury (subAKI) is characterized by tubule-interstitial injury without significant changes in glomerular function. SubAKI is associated with the pathogenesis and progression of acute and chronic kidney diseases. Currently, therapeutic strategies to treat subAKI are limited....