Tumor cell cholesterol depletion and V-ATPase inhibition as an inhibitory mechanism to prevent cell migration and invasiveness in melanoma

• Published in: Biochimica et biophysica acta Vol. 1862; no. 3; pp. 684 - 691
• Main Authors: Costa, Gildeíde Aparecida, de Souza, Sávio Bastos, da Silva Teixeira, Layz Ribeiro, Okorokov, Lev A., Arnholdt, Andrea Cristina Vetö, Okorokova-Façanha, Anna L., Façanha, Arnoldo Rocha
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.03.2018
• Subjects: Antimetastatic target; Cholesterol rafts; Proton pumps; Proton pumps; SIET; Cholesterol rafts; PMSF; MβCD; Antimetastatic target; EDTA

V-ATPase interactions with cholesterol enriched membrane microdomains have been related to metastasis in a variety of cancers, but the underlying mechanism remains at its beginnings. It has recently been reported that the inhibition of this H+ pump affects cholesterol mobilization to the plasma memb...