Mouse prenatal platelet-forming lineages share a core transcriptional program but divergent dependence on MPL

• Published in: Blood Vol. 126; no. 6; pp. 807 - 816
• Main Authors: Potts, Kathryn S., Sargeant, Tobias J., Dawson, Caleb A., Josefsson, Emma C., Hilton, Douglas J., Alexander, Warren S., Taoudi, Samir
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 06.08.2015
• Subjects: Animals; Blood Platelets - cytology; Blood Platelets - metabolism; Cell Differentiation; Cell Lineage - genetics; Embryonic Development - genetics; GATA1 Transcription Factor - deficiency; GATA1 Transcription Factor - genetics; Gene Deletion; Gene Expression Regulation, Developmental; Hematopoietic Stem Cells - cytology; Hematopoietic Stem Cells - metabolism; Megakaryocytes - cytology; Megakaryocytes - metabolism; Mice; Mice, Knockout; NF-E2 Transcription Factor, p45 Subunit - deficiency; NF-E2 Transcription Factor, p45 Subunit - genetics; Receptors, Thrombopoietin - genetics; Receptors, Thrombopoietin - metabolism; Thrombopoiesis - genetics; Transcription, Genetic; Yolk Sac - cytology; Yolk Sac - growth & development; Yolk Sac - metabolism

The thrombopoietic environment of the neonate is established during prenatal life; therefore, a comprehensive understanding of platelet-forming cell development during embryogenesis is critical to understanding the etiology of early-onset thrombocytopenia. The recent discovery that the first platele...