The urinary metabolites of DINCH® have an impact on the activities of the human nuclear receptors ERα, ERβ, AR, PPARα and PPARγ

• Published in: Toxicology letters Vol. 287; pp. 83 - 91
• Main Authors: Engel, Anika, Buhrke, Thorsten, Kasper, Stefanie, Behr, Anne-Cathrin, Braeuning, Albert, Jessel, Sönke, Seidel, Albrecht, Völkel, Wolfgang, Lampen, Alfonso
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.05.2018
• Subjects: Androgen receptor; DINCH; Estrogen receptor; PPAR activation; Steroidogenesis; Estrogen receptor; PPAR activation; Steroidogenesis; DINCH; Androgen receptor; DINCH(®)

•DINCH® does not activate the human hormone receptors ERα, ERβ and AR.•DINCH® metabolites stimulate ERα,ERβ and AR activity.•DINCH® metabolites activate the nuclear receptors PPARα and PPARγ.•DINCH® and its metabolites exert different molecular biological activities. DINCH® (di-isononyl cyclohexane-...