Ultra-high pressure liquid chromatography coupled to travelling wave ion mobility-time of flight mass spectrometry for the screening of pharmaceutical metabolites in wastewater samples: Application to antiretrovirals

• Published in: Journal of Chromatography A Vol. 1660; p. 462650
• Main Authors: Mosekiemang, Tlou T., Stander, Maria A., de Villiers, André
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 20.12.2021
• Subjects: Antiretrovirals; Chromatography, High Pressure Liquid; HIV Infections; Humans; Ion Mobility Spectrometry; Mass defect filtering; Mass Spectrometry; Metabolites; Pharmaceutical Preparations; Waste Water; Wastewater; Mass defect filtering; Antiretrovirals; Ion mobility spectrometry; Metabolites; Wastewater

•UHPLC-IMS-HR-MS method for detection of antiretroviral metabolites in wastewater.•Mass defect filter template implemented to detect phase I and phase II metabolites.•IMS-filtered data improves data visualisation and spectral quality.•Collisional cross sections (CCS) for antiretroviral drugs and met...