Polymorphisms of the DNA repair gene EXO1 modulate cognitive aging in old adults in a Taiwanese population
•The EXO1 rs1776181, rs1776177, rs1635510, and rs2526698 SNPs are associated with cognitive aging.•Interactions between the EXO1 gene and physical activity influence cognitive aging.•Interactions between the DCLRE1C gene and physical activity influence cognitive aging.•Interactions between the EXO1...
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| Published in | DNA repair Vol. 78; pp. 1 - 6 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier B.V
01.06.2019
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1568-7864 1568-7856 1568-7856 |
| DOI | 10.1016/j.dnarep.2019.03.013 |
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| Abstract | •The EXO1 rs1776181, rs1776177, rs1635510, and rs2526698 SNPs are associated with cognitive aging.•Interactions between the EXO1 gene and physical activity influence cognitive aging.•Interactions between the DCLRE1C gene and physical activity influence cognitive aging.•Interactions between the EXO1 and RAD51C genes contribute to cognitive aging.
Evidence indicates that the age-related neuropathological mechanisms associated with DNA repair genes may contribute to cognitive aging and Alzheimer’s disease. In this study, we hypothesize that single nucleotide polymorphisms (SNPs) within 155 DNA repair genes may be linked to cognitive aging independently and/or through complex interactions in an older Taiwanese population. A total of 3,730 Taiwanese subjects aged over 60 years from the Taiwan Biobank were analyzed. Mini-Mental State Examination (MMSE) was administered to all subjects, and MMSE scores were used to measure cognitive functions. Our data showed that out of 1,652 SNPs, the rs1776181 (P = 1.47 × 10−5), rs1776177 (P = 8.42 × 10-7), rs1635510 (P = 7.97 × 10-6), and rs2526698 (P = 7.06 × 10-6) SNPs in the EXO1 gene were associated with cognitive aging. The association with these SNP remained significant after performing Bonferroni correction. Additionally, we found that interactions between the EXO1 and RAD51C genes influenced cognitive aging (P = 0.002). Finally, we pinpointed the influence of interactions between EXO1 and physical activity (P < 0.001) as well as between DCLRE1C and physical activity (P < 0.001). Our study indicated that DNA repair genes may contribute to susceptibility in cognitive aging independently as well as through gene-gene and gene-physical interactions. |
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| AbstractList | Evidence indicates that the age-related neuropathological mechanisms associated with DNA repair genes may contribute to cognitive aging and Alzheimer's disease. In this study, we hypothesize that single nucleotide polymorphisms (SNPs) within 155 DNA repair genes may be linked to cognitive aging independently and/or through complex interactions in an older Taiwanese population. A total of 3,730 Taiwanese subjects aged over 60 years from the Taiwan Biobank were analyzed. Mini-Mental State Examination (MMSE) was administered to all subjects, and MMSE scores were used to measure cognitive functions. Our data showed that out of 1,652 SNPs, the rs1776181 (P = 1.47 × 10
), rs1776177 (P = 8.42 × 10
), rs1635510 (P = 7.97 × 10
), and rs2526698 (P = 7.06 × 10
) SNPs in the EXO1 gene were associated with cognitive aging. The association with these SNP remained significant after performing Bonferroni correction. Additionally, we found that interactions between the EXO1 and RAD51C genes influenced cognitive aging (P = 0.002). Finally, we pinpointed the influence of interactions between EXO1 and physical activity (P < 0.001) as well as between DCLRE1C and physical activity (P < 0.001). Our study indicated that DNA repair genes may contribute to susceptibility in cognitive aging independently as well as through gene-gene and gene-physical interactions. Evidence indicates that the age-related neuropathological mechanisms associated with DNA repair genes may contribute to cognitive aging and Alzheimer's disease. In this study, we hypothesize that single nucleotide polymorphisms (SNPs) within 155 DNA repair genes may be linked to cognitive aging independently and/or through complex interactions in an older Taiwanese population. A total of 3,730 Taiwanese subjects aged over 60 years from the Taiwan Biobank were analyzed. Mini-Mental State Examination (MMSE) was administered to all subjects, and MMSE scores were used to measure cognitive functions. Our data showed that out of 1,652 SNPs, the rs1776181 (P = 1.47 × 10-5), rs1776177 (P = 8.42 × 10-7), rs1635510 (P = 7.97 × 10-6), and rs2526698 (P = 7.06 × 10-6) SNPs in the EXO1 gene were associated with cognitive aging. The association with these SNP remained significant after performing Bonferroni correction. Additionally, we found that interactions between the EXO1 and RAD51C genes influenced cognitive aging (P = 0.002). Finally, we pinpointed the influence of interactions between EXO1 and physical activity (P < 0.001) as well as between DCLRE1C and physical activity (P < 0.001). Our study indicated that DNA repair genes may contribute to susceptibility in cognitive aging independently as well as through gene-gene and gene-physical interactions.Evidence indicates that the age-related neuropathological mechanisms associated with DNA repair genes may contribute to cognitive aging and Alzheimer's disease. In this study, we hypothesize that single nucleotide polymorphisms (SNPs) within 155 DNA repair genes may be linked to cognitive aging independently and/or through complex interactions in an older Taiwanese population. A total of 3,730 Taiwanese subjects aged over 60 years from the Taiwan Biobank were analyzed. Mini-Mental State Examination (MMSE) was administered to all subjects, and MMSE scores were used to measure cognitive functions. Our data showed that out of 1,652 SNPs, the rs1776181 (P = 1.47 × 10-5), rs1776177 (P = 8.42 × 10-7), rs1635510 (P = 7.97 × 10-6), and rs2526698 (P = 7.06 × 10-6) SNPs in the EXO1 gene were associated with cognitive aging. The association with these SNP remained significant after performing Bonferroni correction. Additionally, we found that interactions between the EXO1 and RAD51C genes influenced cognitive aging (P = 0.002). Finally, we pinpointed the influence of interactions between EXO1 and physical activity (P < 0.001) as well as between DCLRE1C and physical activity (P < 0.001). Our study indicated that DNA repair genes may contribute to susceptibility in cognitive aging independently as well as through gene-gene and gene-physical interactions. •The EXO1 rs1776181, rs1776177, rs1635510, and rs2526698 SNPs are associated with cognitive aging.•Interactions between the EXO1 gene and physical activity influence cognitive aging.•Interactions between the DCLRE1C gene and physical activity influence cognitive aging.•Interactions between the EXO1 and RAD51C genes contribute to cognitive aging. Evidence indicates that the age-related neuropathological mechanisms associated with DNA repair genes may contribute to cognitive aging and Alzheimer’s disease. In this study, we hypothesize that single nucleotide polymorphisms (SNPs) within 155 DNA repair genes may be linked to cognitive aging independently and/or through complex interactions in an older Taiwanese population. A total of 3,730 Taiwanese subjects aged over 60 years from the Taiwan Biobank were analyzed. Mini-Mental State Examination (MMSE) was administered to all subjects, and MMSE scores were used to measure cognitive functions. Our data showed that out of 1,652 SNPs, the rs1776181 (P = 1.47 × 10−5), rs1776177 (P = 8.42 × 10-7), rs1635510 (P = 7.97 × 10-6), and rs2526698 (P = 7.06 × 10-6) SNPs in the EXO1 gene were associated with cognitive aging. The association with these SNP remained significant after performing Bonferroni correction. Additionally, we found that interactions between the EXO1 and RAD51C genes influenced cognitive aging (P = 0.002). Finally, we pinpointed the influence of interactions between EXO1 and physical activity (P < 0.001) as well as between DCLRE1C and physical activity (P < 0.001). Our study indicated that DNA repair genes may contribute to susceptibility in cognitive aging independently as well as through gene-gene and gene-physical interactions. |
| Author | Liu, Yu-Li Tsai, Shih-Jen Lin, Eugene Yang, Albert C. Kuo, Po-Hsiu |
| Author_xml | – sequence: 1 givenname: Eugene surname: Lin fullname: Lin, Eugene email: lines@uw.edu organization: Department of Biostatistics, University of Washington, Seattle, WA, 98195, USA – sequence: 2 givenname: Po-Hsiu surname: Kuo fullname: Kuo, Po-Hsiu organization: Department of Public Health, Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan – sequence: 3 givenname: Yu-Li surname: Liu fullname: Liu, Yu-Li organization: Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli County, Taiwan – sequence: 4 givenname: Albert C. surname: Yang fullname: Yang, Albert C. organization: Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan – sequence: 5 givenname: Shih-Jen surname: Tsai fullname: Tsai, Shih-Jen email: tsai610913@gmail.com organization: Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30928815$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_18632_aging_203321 crossref_primary_10_1093_hmg_ddab202 crossref_primary_10_1155_2021_9918498 crossref_primary_10_3390_ijms21030969 crossref_primary_10_1186_s40478_021_01190_x crossref_primary_10_2147_DMSO_S309242 crossref_primary_10_1016_j_mrgentox_2022_503499 crossref_primary_10_1186_s12920_021_01083_x crossref_primary_10_52667_2712_9179_2024_4_4_11_25 crossref_primary_10_3389_fneur_2019_01065 crossref_primary_10_1186_s12883_023_03503_0 |
| Cites_doi | 10.1086/519795 10.1126/science.276.5318.1560 10.3390/ijms20010097 10.1159/000443953 10.1016/j.freeradbiomed.2008.06.003 10.1038/nature12531 10.1016/j.dnarep.2013.04.010 10.1002/gcc.22239 10.1016/j.tics.2015.06.008 10.1016/j.mrfmmm.2012.03.003 10.1126/science.1262110 10.1093/geront/37.4.433 10.1086/518312 10.1016/j.neurobiolaging.2009.12.006 10.1016/j.mrfmmm.2014.12.011 10.1126/science.1056154 10.1159/000099471 10.3390/ijms20010074 10.1093/nar/gkm605 10.1016/j.dnarep.2013.07.005 10.1093/nar/30.4.1009 10.1038/srep36830 10.1016/S0166-2236(00)01625-8 10.1016/j.dnarep.2008.03.005 10.1080/10409238.2016.1215407 10.3390/cancers6031597 10.1371/journal.pone.0110696 10.1177/1756285612455733 10.1159/000444643 10.1038/s41598-017-14025-4 10.1002/humu.21168 10.1038/nature02661 10.1093/carcin/bgv127 10.1002/jcla.20379 10.1158/1940-6207.CAPR-17-0413 10.1001/archinternmed.2007.39 10.1016/j.mrfmmm.2006.06.007 10.3389/fpsyt.2018.00290 10.1016/j.mrfmmm.2005.03.007 10.1159/000455833 10.1523/JNEUROSCI.1589-11.2011 10.18632/oncotarget.15269 10.18632/oncotarget.15493 10.18632/oncotarget.20967 10.1016/j.canlet.2016.07.011 10.1159/000381985 |
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| Keywords | Cognitive aging Single nucleotide polymorphisms Neurodegeneration Gene-gene interactions Alzheimer’s diseases Cognitive impairment |
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| References | Weissman, Jo, Sørensen, de Souza-Pinto, Markesbery, Mattson, Bohr (bib0115) 2007; 35 Joyce, Zheng, Nannini, Zhang, Liu, Gao, Kocherginsky, Murphy, Yang, Achenbach (bib0240) 2018 Liu, Schild, Thelen, Thompson (bib0250) 2002; 30 Shao, Xiong, Li, Gu, Mao, Markesbery, Lovell (bib0110) 2008; 45 Purcell, Neale, Todd-Brown, Thomas, Ferreira, Bender, Maller, Sklar, De Bakker, Daly (bib0190) 2007; 81 Lin, Tsai, Kuo, Liu, Yang, Kao, Yang (bib0140) 2017; 43 Rowe, Kahn (bib0005) 1997; 37 Lin, Tsai, Kuo, Liu, Yang, Kao (bib0145) 2017; 8 Anson, Bohr (bib0220) 2000; 23 Infante, Llorca, Mateo, Rodríguez-Rodríguez, Sánchez-Quintana, Sánchez-Juan, Fernández-Viadero, Peña, Berciano, Combarros (bib0060) 2007; 23 Kwiatkowski, Czarny, Galecki, Bachurska, Talarowska, Orzechowska, Bobińska, Bielecka-Kowalska, Pietras, Szemraj (bib0070) 2015; 71 Canugovi, Misiak, Ferrarelli, Croteau, Bohr (bib0050) 2013; 12 Kwiatkowski, Czarny, Toma, Jurkowska, Sliwinska, Drzewoski, Bachurska, Szemraj, Maes, Berk (bib0080) 2016; 41 Lin, Kuo, Liu, Yang, Kao, Tsai (bib0150) 2017; 8 Dusinska, Staruchova, Horska, Smolkova, Collins, Bonassi, Volkovova (bib0085) 2012; 736 Lin, Kuo, Liu, Yang, Kao, Tsai (bib0185) 2017; 12 Goode, Ulrich, Potter (bib0035) 2002; 11 Fishel, Vasko, Kelley (bib0040) 2007; 614 Pannicke, Hönig, Schulze, Rohr, Heinz, Braun, Janz, Rump, Seidel, Matthes‐Martin (bib0230) 2010; 31 Gresner, Gromadzinska, Jablonska, Stepnik, Quispe, Twardowska, Wasowicz (bib0255) 2014; 9 Lin, Kuo, Liu, Yang, Kao, Tsai (bib0175) 2016; 6 Consortium (bib0200) 2015; 348 Papenberg, Lindenberger, Backman (bib0015) 2015; 19 Lu, Pan, Kao, Li, Kohane, Chan, Yankner (bib0025) 2004; 429 Bucholtz, Demuth (bib0045) 2013; 12 Lin, Kuo, Liu, Yu, Yang, Tsai (bib0265) 2018; 9 Purcell, Neale, Todd-Brown, Thomas, Ferreira, Bender, Maller, Sklar, de Bakker, Daly, Sham (bib0180) 2007; 81 Borgesius, de Waard, van der Pluijm, Omrani, Zondag, van der Horst, Melton, Hoeijmakers, Jaarsma, Elgersma (bib0105) 2011; 31 McClearn, Johansson, Berg, Pedersen, Ahern, Petrill, Plomin (bib0010) 1997; 276 Lin, Yang, Tsai (bib0130) 2017; 31 Leandro, Sykora, Bohr (bib0055) 2015; 776 Vodicka, Musak, Frank, Kazimirova, Vymetalkova, Barancokova, Smolkova, Dzupinkova, Jiraskova, Vodenkova (bib0100) 2015; 36 Kwiatkowski, Czarny, Toma, Korycinska, Sowinska, Galecki, Bachurska, Bielecka-Kowalska, Szemraj, Maes (bib0075) 2016; 73 Keijzers, Liu, Rasmussen (bib0210) 2016; 51 Bridge, Rashid, Martin (bib0225) 2014; 6 Lappalainen, Sammeth, Friedlander, t Hoen, Monlong, Rivas, Gonzalez-Porta, Kurbatova, Griebel, Ferreira, Barann, Wieland, Greger, van Iterson, Almlof, Ribeca, Pulyakhina, Esser, Giger, Tikhonov, Sultan, Bertier, MacArthur, Lek, Lizano, Buermans, Padioleau, Schwarzmayr, Karlberg, Ongen, Kilpinen, Beltran, Gut, Kahlem, Amstislavskiy, Stegle, Pirinen, Montgomery, Donnelly, McCarthy, Flicek, Strom, Geuvadis, Lehrach, Schreiber, Sudbrak, Carracedo, Antonarakis, Hasler, Syvanen, van Ommen, Brazma, Meitinger, Rosenstiel, Guigo, Gut, Estivill, Dermitzakis (bib0205) 2013; 501 Lin, Kuo, Liu, Yang, Tsai (bib0260) 2017; 8 Jiraskova, Hughes, Brezina, Gumpenberger, Veskrnova, Buchler, Schneiderova, Levy, Liska, Vodenkova, Di Gaetano, Naccarati, Pardini, Vymetalkova, Gsur, Vodicka (bib0170) 2019; 20 Liu, Lin, Wu, Liu, Wang, Tsai, Lee, Tsai (bib0065) 2010; 24 Wood, Mitchell, Lindahl (bib0120) 2005; 577 Lin, Kuo, Liu, Yang, Tsai (bib0165) 2017; 7 Sheehan (bib0160) 2012; 5 Keijzers, Bakula, Petr, Madsen, Teklu, Mkrtchyan, Osborne, Scheibye-Knudsen (bib0215) 2019; 20 Barzilai, Biton, Shiloh (bib0030) 2008; 7 Lou, Chen, Yan, Ma, Zhu, Elston, Li (bib0195) 2007; 80 Wood, Mitchell, Sgouros, Lindahl (bib0125) 2001; 291 Försti, Frank, Smolkova, Kazimirova, Barancokova, Vymetalkova, Kroupa, Naccarati, Vodickova, Buchancova (bib0090) 2016; 380 Lin, Tsai, Kuo, Liu, Yang, Kao, Yang (bib0135) 2017; 12 Hemminki, Frank, Försti, Musak, Kazimirova, Barancokova, Horska, Vymetalkova, Smerhovsky, Naccarati (bib0095) 2015; 54 Yaffe, Lindquist, Kluse, Cawthon, Harris, Hsueh, Simonsick, Kuller, Li, Ayonayon (bib0235) 2011; 32 Cherkas, Hunkin, Kato, Richards, Gardner, Surdulescu, Kimura, Lu, Spector, Aviv (bib0245) 2008; 168 Chen, Yang, Chiang, Hsiung, Wu, Chang, Chu, Chang, Song, Yang, Chen, Liu, Shen (bib0155) 2016; 25 Rolig, McKinnon (bib0020) 2000; 23 Yaffe (10.1016/j.dnarep.2019.03.013_bib0235) 2011; 32 Cherkas (10.1016/j.dnarep.2019.03.013_bib0245) 2008; 168 Lin (10.1016/j.dnarep.2019.03.013_bib0165) 2017; 7 Canugovi (10.1016/j.dnarep.2019.03.013_bib0050) 2013; 12 Lin (10.1016/j.dnarep.2019.03.013_bib0150) 2017; 8 Vodicka (10.1016/j.dnarep.2019.03.013_bib0100) 2015; 36 Jiraskova (10.1016/j.dnarep.2019.03.013_bib0170) 2019; 20 Liu (10.1016/j.dnarep.2019.03.013_bib0250) 2002; 30 Sheehan (10.1016/j.dnarep.2019.03.013_bib0160) 2012; 5 Lin (10.1016/j.dnarep.2019.03.013_bib0185) 2017; 12 Hemminki (10.1016/j.dnarep.2019.03.013_bib0095) 2015; 54 Lin (10.1016/j.dnarep.2019.03.013_bib0265) 2018; 9 Lu (10.1016/j.dnarep.2019.03.013_bib0025) 2004; 429 Rolig (10.1016/j.dnarep.2019.03.013_bib0020) 2000; 23 Kwiatkowski (10.1016/j.dnarep.2019.03.013_bib0070) 2015; 71 Weissman (10.1016/j.dnarep.2019.03.013_bib0115) 2007; 35 Dusinska (10.1016/j.dnarep.2019.03.013_bib0085) 2012; 736 Wood (10.1016/j.dnarep.2019.03.013_bib0125) 2001; 291 Lin (10.1016/j.dnarep.2019.03.013_bib0130) 2017; 31 Papenberg (10.1016/j.dnarep.2019.03.013_bib0015) 2015; 19 Joyce (10.1016/j.dnarep.2019.03.013_bib0240) 2018 Consortium (10.1016/j.dnarep.2019.03.013_bib0200) 2015; 348 Purcell (10.1016/j.dnarep.2019.03.013_bib0190) 2007; 81 Lou (10.1016/j.dnarep.2019.03.013_bib0195) 2007; 80 Anson (10.1016/j.dnarep.2019.03.013_bib0220) 2000; 23 Försti (10.1016/j.dnarep.2019.03.013_bib0090) 2016; 380 Chen (10.1016/j.dnarep.2019.03.013_bib0155) 2016; 25 Fishel (10.1016/j.dnarep.2019.03.013_bib0040) 2007; 614 Lin (10.1016/j.dnarep.2019.03.013_bib0175) 2016; 6 Lappalainen (10.1016/j.dnarep.2019.03.013_bib0205) 2013; 501 Purcell (10.1016/j.dnarep.2019.03.013_bib0180) 2007; 81 Pannicke (10.1016/j.dnarep.2019.03.013_bib0230) 2010; 31 Gresner (10.1016/j.dnarep.2019.03.013_bib0255) 2014; 9 Lin (10.1016/j.dnarep.2019.03.013_bib0145) 2017; 8 Kwiatkowski (10.1016/j.dnarep.2019.03.013_bib0075) 2016; 73 Shao (10.1016/j.dnarep.2019.03.013_bib0110) 2008; 45 Lin (10.1016/j.dnarep.2019.03.013_bib0135) 2017; 12 Barzilai (10.1016/j.dnarep.2019.03.013_bib0030) 2008; 7 Leandro (10.1016/j.dnarep.2019.03.013_bib0055) 2015; 776 Wood (10.1016/j.dnarep.2019.03.013_bib0120) 2005; 577 Kwiatkowski (10.1016/j.dnarep.2019.03.013_bib0080) 2016; 41 Keijzers (10.1016/j.dnarep.2019.03.013_bib0210) 2016; 51 McClearn (10.1016/j.dnarep.2019.03.013_bib0010) 1997; 276 Rowe (10.1016/j.dnarep.2019.03.013_bib0005) 1997; 37 Infante (10.1016/j.dnarep.2019.03.013_bib0060) 2007; 23 Keijzers (10.1016/j.dnarep.2019.03.013_bib0215) 2019; 20 Goode (10.1016/j.dnarep.2019.03.013_bib0035) 2002; 11 Lin (10.1016/j.dnarep.2019.03.013_bib0140) 2017; 43 Bridge (10.1016/j.dnarep.2019.03.013_bib0225) 2014; 6 Liu (10.1016/j.dnarep.2019.03.013_bib0065) 2010; 24 Borgesius (10.1016/j.dnarep.2019.03.013_bib0105) 2011; 31 Bucholtz (10.1016/j.dnarep.2019.03.013_bib0045) 2013; 12 Lin (10.1016/j.dnarep.2019.03.013_bib0260) 2017; 8 |
| References_xml | – volume: 81 start-page: 559 year: 2007 end-page: 575 ident: bib0180 article-title: PLINK: a tool set for whole-genome association and population-based linkage analyses publication-title: Am. J. Hum. Genet. – volume: 20 start-page: 97 year: 2019 ident: bib0170 article-title: Functional polymorphisms in DNA repair genes are associated with sporadic colorectal Cancer susceptibility and clinical outcome publication-title: Int. J. Mol. Sci. – volume: 348 start-page: 648 year: 2015 end-page: 660 ident: bib0200 article-title: Human genomics. The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans publication-title: Science – volume: 31 start-page: 12543 year: 2011 end-page: 12553 ident: bib0105 article-title: Accelerated age-related cognitive decline and neurodegeneration, caused by deficient DNA repair publication-title: J. Neurosci. – volume: 11 start-page: 1513 year: 2002 end-page: 1530 ident: bib0035 article-title: Polymorphisms in DNA repair genes and associations with cancer risk publication-title: Cancer Epidemiol. Prevent. Biomark. – volume: 35 start-page: 5545 year: 2007 end-page: 5555 ident: bib0115 article-title: Defective DNA base excision repair in brain from individuals with Alzheimer’s disease and amnestic mild cognitive impairment publication-title: Nucleic Acids Res. – volume: 71 start-page: 176 year: 2015 end-page: 186 ident: bib0070 article-title: Variants of base excision repair genes MUTYH, PARP1 and XRCC1 in Alzheimer’s disease risk publication-title: Neuropsychobiology – volume: 8 start-page: 93349 year: 2017 end-page: 93359 ident: bib0260 article-title: Detection of susceptibility loci on APOA5 and COLEC12 associated with metabolic syndrome using a genome-wide association study in a Taiwanese population publication-title: Oncotarget – volume: 776 start-page: 31 year: 2015 end-page: 39 ident: bib0055 article-title: The impact of base excision DNA repair in age-related neurodegenerative diseases publication-title: Mutat. Res. Mol. Mech. Mutagen. – volume: 23 start-page: 199 year: 2000 ident: bib0220 article-title: Mitochondria, oxidative DNA damage, and aging publication-title: J. Am. Aging Assoc. – volume: 51 start-page: 440 year: 2016 end-page: 451 ident: bib0210 article-title: Exonuclease 1 and its versatile roles in DNA repair publication-title: Crit. Rev. Biochem. Mol. Biol. – volume: 9 year: 2014 ident: bib0255 article-title: Single nucleotide polymorphisms in noncoding regions of Rad51C do not change the risk of unselected breast cancer but they modulate the level of oxidative stress and the DNA damage characteristics: a case-control study publication-title: PLoS One – year: 2018 ident: bib0240 article-title: DNA methylation of telomere-related genes and Cancer risk publication-title: Cancer Prev. Res. – volume: 23 start-page: 417 year: 2000 end-page: 424 ident: bib0020 article-title: Linking DNA damage and neurodegeneration publication-title: Trends Neurosci. – volume: 31 start-page: 197 year: 2010 end-page: 207 ident: bib0230 article-title: The most frequent DCLRE1C (ARTEMIS) mutations are based on homologous recombination events publication-title: Hum. Mutat. – volume: 43 start-page: 119 year: 2017 end-page: 127 ident: bib0140 article-title: The rs1277306 variant of the REST gene confers susceptibility to cognitive aging in an elderly Taiwanese population publication-title: Dement. Geriatr. Cogn. Disord. – volume: 12 year: 2017 ident: bib0185 article-title: Effects of circadian clock genes and health-related behavior on metabolic syndrome in a Taiwanese population: evidence from association and interaction analysis publication-title: PLoS One – volume: 54 start-page: 260 year: 2015 end-page: 266 ident: bib0095 article-title: Metabolic gene variants associated with chromosomal aberrations in healthy humans publication-title: Genes Chromosomes Cancer – volume: 36 start-page: 1299 year: 2015 end-page: 1306 ident: bib0100 article-title: Interactions of DNA repair gene variants modulate chromosomal aberrations in healthy subjects publication-title: Carcinogenesis – volume: 6 start-page: 1597 year: 2014 end-page: 1614 ident: bib0225 article-title: DNA mismatch repair and oxidative DNA damage: implications for cancer biology and treatment publication-title: Cancers – volume: 12 start-page: 811 year: 2013 end-page: 816 ident: bib0045 article-title: DNA-repair in mild cognitive impairment and Alzheimer’s disease publication-title: DNA Rep. – volume: 24 start-page: 182 year: 2010 end-page: 186 ident: bib0065 article-title: Evaluation of the poly (ADP‐ribose) polymerase‐1 gene variants in Alzheimer’s disease publication-title: J. Clin. Lab. Anal. – volume: 23 start-page: 215 year: 2007 end-page: 218 ident: bib0060 article-title: Interaction between poly (ADP-ribose) polymerase 1 and interleukin 1A genes is associated with Alzheimer’s disease risk publication-title: Dement. Geriatr. Cogn. Disord. – volume: 501 start-page: 506 year: 2013 end-page: 511 ident: bib0205 article-title: Transcriptome and genome sequencing uncovers functional variation in humans publication-title: Nature – volume: 736 start-page: 130 year: 2012 end-page: 137 ident: bib0085 article-title: Are glutathione S transferases involved in DNA damage signalling? Interactions with DNA damage and repair revealed from molecular epidemiology studies publication-title: Mutat. Res. Mol. Mech. Mutagen. – volume: 12 year: 2017 ident: bib0135 article-title: The ADAMTS9 gene is associated with cognitive aging in the elderly in a Taiwanese population publication-title: PLoS One – volume: 380 start-page: 442 year: 2016 end-page: 446 ident: bib0090 article-title: Genetic variation in the major mitotic checkpoint genes associated with chromosomal aberrations in healthy humans publication-title: Cancer Lett. – volume: 45 start-page: 813 year: 2008 end-page: 819 ident: bib0110 article-title: Altered 8-oxoguanine glycosylase in mild cognitive impairment and late-stage Alzheimer’s disease brain publication-title: Free Radic. Biol. Med. – volume: 25 start-page: 5321 year: 2016 end-page: 5331 ident: bib0155 article-title: Population structure of Han Chinese in the modern Taiwanese population based on 10,000 participants in the Taiwan Biobank project publication-title: Hum. Mol. Genet. – volume: 168 start-page: 154 year: 2008 end-page: 158 ident: bib0245 article-title: The association between physical activity in leisure time and leukocyte telomere length publication-title: Arch. Intern. Med. – volume: 30 start-page: 1009 year: 2002 end-page: 1015 ident: bib0250 article-title: Involvement of Rad51C in two distinct protein complexes of Rad51 paralogs in human cells publication-title: Nucleic Acids Res. – volume: 73 start-page: 98 year: 2016 end-page: 107 ident: bib0075 article-title: Association between single-nucleotide polymorphisms of the hOGG1, NEIL1, APEX1, FEN1, LIG1, and LIG3 genes and Alzheimer’s disease risk publication-title: Neuropsychobiology – volume: 6 start-page: 36830 year: 2016 ident: bib0175 article-title: Association and interaction of APOA5, BUD13, CETP, LIPA and health-related behavior with metabolic syndrome in a Taiwanese population publication-title: Sci. Rep. – volume: 9 start-page: 290 year: 2018 ident: bib0265 article-title: A deep learning approach for predicting antidepressant response in major depression using clinical and genetic biomarkers publication-title: Front. Psychiatry – volume: 8 start-page: 24088 year: 2017 end-page: 24098 ident: bib0150 article-title: Effects of circadian clock genes and environmental factors on cognitive aging in old adults in a Taiwanese population publication-title: Oncotarget – volume: 429 start-page: 883 year: 2004 ident: bib0025 article-title: Gene regulation and DNA damage in the ageing human brain publication-title: Nature – volume: 12 start-page: 578 year: 2013 end-page: 587 ident: bib0050 article-title: The role of DNA repair in brain related disease pathology publication-title: DNA Rep. – volume: 37 start-page: 433 year: 1997 end-page: 440 ident: bib0005 article-title: Successful aging publication-title: Gerontologist – volume: 7 start-page: 1010 year: 2008 end-page: 1027 ident: bib0030 article-title: The role of the DNA damage response in neuronal development, organization and maintenance publication-title: DNA Rep. – volume: 614 start-page: 24 year: 2007 end-page: 36 ident: bib0040 article-title: DNA repair in neurons: so if they don’t divide what’s to repair? publication-title: Mutat. Res. Mol. Mech. Mutagen. – volume: 291 start-page: 1284 year: 2001 end-page: 1289 ident: bib0125 article-title: Human DNA repair genes publication-title: Science – volume: 20 start-page: 74 year: 2019 ident: bib0215 article-title: Human Exonuclease 1 (EXO1) Regulatory Functions in DNA Replication with Putative Roles in Cancer publication-title: Int. J. Mol. Sci. – volume: 80 start-page: 1125 year: 2007 end-page: 1137 ident: bib0195 article-title: A generalized combinatorial approach for detecting gene-by-gene and gene-by-environment interactions with application to nicotine dependence publication-title: Am. J. Hum. Genet. – volume: 8 start-page: 24077 year: 2017 end-page: 24087 ident: bib0145 article-title: Association and interaction effects of Alzheimer’s disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population publication-title: Oncotarget – volume: 577 start-page: 275 year: 2005 end-page: 283 ident: bib0120 article-title: Human DNA repair genes, 2005 publication-title: Mutat. Res. – volume: 276 start-page: 1560 year: 1997 end-page: 1563 ident: bib0010 article-title: Substantial genetic influence on cognitive abilities in twins 80 or more years old publication-title: Science – volume: 5 start-page: 349 year: 2012 end-page: 358 ident: bib0160 article-title: Assessment scales in dementia publication-title: Ther. Adv. Neurol. Disord. – volume: 41 start-page: 152 year: 2016 end-page: 171 ident: bib0080 article-title: Associations between DNA damage, DNA base excision repair gene variability and Alzheimer’s disease risk publication-title: Dement. Geriatr. Cogn. Disord. – volume: 32 start-page: 2055 year: 2011 end-page: 2060 ident: bib0235 article-title: Telomere length and cognitive function in community-dwelling elders: findings from the Health ABC Study publication-title: Neurobiol. Aging – volume: 19 start-page: 506 year: 2015 end-page: 514 ident: bib0015 article-title: Aging-related magnification of genetic effects on cognitive and brain integrity publication-title: Trends Cogn. Sci. – volume: 31 start-page: 232 year: 2017 end-page: 240 ident: bib0130 article-title: Association between metabolic syndrome and cognitive function in old adults in a Taiwanese population publication-title: Taiwan. J. Psychiatry – volume: 81 start-page: 559 year: 2007 end-page: 575 ident: bib0190 article-title: PLINK: a tool set for whole-genome association and population-based linkage analyses publication-title: Am. J. Hum. Genet. – volume: 7 start-page: 13589 year: 2017 ident: bib0165 article-title: Transforming growth factor-beta signaling pathway-associated genes SMAD2 and TGFBR2 are implicated in metabolic syndrome in a Taiwanese population publication-title: Sci. Rep. – volume: 81 start-page: 559 year: 2007 ident: 10.1016/j.dnarep.2019.03.013_bib0190 article-title: PLINK: a tool set for whole-genome association and population-based linkage analyses publication-title: Am. J. Hum. Genet. doi: 10.1086/519795 – volume: 276 start-page: 1560 year: 1997 ident: 10.1016/j.dnarep.2019.03.013_bib0010 article-title: Substantial genetic influence on cognitive abilities in twins 80 or more years old publication-title: Science doi: 10.1126/science.276.5318.1560 – volume: 20 start-page: 97 year: 2019 ident: 10.1016/j.dnarep.2019.03.013_bib0170 article-title: Functional polymorphisms in DNA repair genes are associated with sporadic colorectal Cancer susceptibility and clinical outcome publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms20010097 – volume: 41 start-page: 152 year: 2016 ident: 10.1016/j.dnarep.2019.03.013_bib0080 article-title: Associations between DNA damage, DNA base excision repair gene variability and Alzheimer’s disease risk publication-title: Dement. Geriatr. Cogn. Disord. doi: 10.1159/000443953 – volume: 45 start-page: 813 year: 2008 ident: 10.1016/j.dnarep.2019.03.013_bib0110 article-title: Altered 8-oxoguanine glycosylase in mild cognitive impairment and late-stage Alzheimer’s disease brain publication-title: Free Radic. Biol. Med. doi: 10.1016/j.freeradbiomed.2008.06.003 – volume: 501 start-page: 506 year: 2013 ident: 10.1016/j.dnarep.2019.03.013_bib0205 article-title: Transcriptome and genome sequencing uncovers functional variation in humans publication-title: Nature doi: 10.1038/nature12531 – volume: 23 start-page: 199 year: 2000 ident: 10.1016/j.dnarep.2019.03.013_bib0220 article-title: Mitochondria, oxidative DNA damage, and aging publication-title: J. Am. Aging Assoc. – volume: 12 start-page: 578 year: 2013 ident: 10.1016/j.dnarep.2019.03.013_bib0050 article-title: The role of DNA repair in brain related disease pathology publication-title: DNA Rep. doi: 10.1016/j.dnarep.2013.04.010 – volume: 54 start-page: 260 year: 2015 ident: 10.1016/j.dnarep.2019.03.013_bib0095 article-title: Metabolic gene variants associated with chromosomal aberrations in healthy humans publication-title: Genes Chromosomes Cancer doi: 10.1002/gcc.22239 – volume: 19 start-page: 506 year: 2015 ident: 10.1016/j.dnarep.2019.03.013_bib0015 article-title: Aging-related magnification of genetic effects on cognitive and brain integrity publication-title: Trends Cogn. Sci. doi: 10.1016/j.tics.2015.06.008 – volume: 736 start-page: 130 year: 2012 ident: 10.1016/j.dnarep.2019.03.013_bib0085 article-title: Are glutathione S transferases involved in DNA damage signalling? Interactions with DNA damage and repair revealed from molecular epidemiology studies publication-title: Mutat. Res. Mol. Mech. Mutagen. doi: 10.1016/j.mrfmmm.2012.03.003 – volume: 348 start-page: 648 year: 2015 ident: 10.1016/j.dnarep.2019.03.013_bib0200 article-title: Human genomics. The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans publication-title: Science doi: 10.1126/science.1262110 – volume: 37 start-page: 433 year: 1997 ident: 10.1016/j.dnarep.2019.03.013_bib0005 article-title: Successful aging publication-title: Gerontologist doi: 10.1093/geront/37.4.433 – volume: 80 start-page: 1125 year: 2007 ident: 10.1016/j.dnarep.2019.03.013_bib0195 article-title: A generalized combinatorial approach for detecting gene-by-gene and gene-by-environment interactions with application to nicotine dependence publication-title: Am. J. Hum. Genet. doi: 10.1086/518312 – volume: 32 start-page: 2055 year: 2011 ident: 10.1016/j.dnarep.2019.03.013_bib0235 article-title: Telomere length and cognitive function in community-dwelling elders: findings from the Health ABC Study publication-title: Neurobiol. Aging doi: 10.1016/j.neurobiolaging.2009.12.006 – volume: 11 start-page: 1513 year: 2002 ident: 10.1016/j.dnarep.2019.03.013_bib0035 article-title: Polymorphisms in DNA repair genes and associations with cancer risk publication-title: Cancer Epidemiol. Prevent. Biomark. – volume: 31 start-page: 232 year: 2017 ident: 10.1016/j.dnarep.2019.03.013_bib0130 article-title: Association between metabolic syndrome and cognitive function in old adults in a Taiwanese population publication-title: Taiwan. J. Psychiatry – volume: 776 start-page: 31 year: 2015 ident: 10.1016/j.dnarep.2019.03.013_bib0055 article-title: The impact of base excision DNA repair in age-related neurodegenerative diseases publication-title: Mutat. Res. Mol. Mech. Mutagen. doi: 10.1016/j.mrfmmm.2014.12.011 – volume: 12 year: 2017 ident: 10.1016/j.dnarep.2019.03.013_bib0135 article-title: The ADAMTS9 gene is associated with cognitive aging in the elderly in a Taiwanese population publication-title: PLoS One – volume: 291 start-page: 1284 year: 2001 ident: 10.1016/j.dnarep.2019.03.013_bib0125 article-title: Human DNA repair genes publication-title: Science doi: 10.1126/science.1056154 – volume: 23 start-page: 215 year: 2007 ident: 10.1016/j.dnarep.2019.03.013_bib0060 article-title: Interaction between poly (ADP-ribose) polymerase 1 and interleukin 1A genes is associated with Alzheimer’s disease risk publication-title: Dement. Geriatr. Cogn. Disord. doi: 10.1159/000099471 – volume: 20 start-page: 74 year: 2019 ident: 10.1016/j.dnarep.2019.03.013_bib0215 article-title: Human Exonuclease 1 (EXO1) Regulatory Functions in DNA Replication with Putative Roles in Cancer publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms20010074 – volume: 35 start-page: 5545 year: 2007 ident: 10.1016/j.dnarep.2019.03.013_bib0115 article-title: Defective DNA base excision repair in brain from individuals with Alzheimer’s disease and amnestic mild cognitive impairment publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkm605 – volume: 12 year: 2017 ident: 10.1016/j.dnarep.2019.03.013_bib0185 article-title: Effects of circadian clock genes and health-related behavior on metabolic syndrome in a Taiwanese population: evidence from association and interaction analysis publication-title: PLoS One – volume: 12 start-page: 811 year: 2013 ident: 10.1016/j.dnarep.2019.03.013_bib0045 article-title: DNA-repair in mild cognitive impairment and Alzheimer’s disease publication-title: DNA Rep. doi: 10.1016/j.dnarep.2013.07.005 – volume: 30 start-page: 1009 year: 2002 ident: 10.1016/j.dnarep.2019.03.013_bib0250 article-title: Involvement of Rad51C in two distinct protein complexes of Rad51 paralogs in human cells publication-title: Nucleic Acids Res. doi: 10.1093/nar/30.4.1009 – volume: 6 start-page: 36830 year: 2016 ident: 10.1016/j.dnarep.2019.03.013_bib0175 article-title: Association and interaction of APOA5, BUD13, CETP, LIPA and health-related behavior with metabolic syndrome in a Taiwanese population publication-title: Sci. Rep. doi: 10.1038/srep36830 – volume: 23 start-page: 417 year: 2000 ident: 10.1016/j.dnarep.2019.03.013_bib0020 article-title: Linking DNA damage and neurodegeneration publication-title: Trends Neurosci. doi: 10.1016/S0166-2236(00)01625-8 – volume: 7 start-page: 1010 year: 2008 ident: 10.1016/j.dnarep.2019.03.013_bib0030 article-title: The role of the DNA damage response in neuronal development, organization and maintenance publication-title: DNA Rep. doi: 10.1016/j.dnarep.2008.03.005 – volume: 51 start-page: 440 year: 2016 ident: 10.1016/j.dnarep.2019.03.013_bib0210 article-title: Exonuclease 1 and its versatile roles in DNA repair publication-title: Crit. Rev. Biochem. Mol. Biol. doi: 10.1080/10409238.2016.1215407 – volume: 6 start-page: 1597 year: 2014 ident: 10.1016/j.dnarep.2019.03.013_bib0225 article-title: DNA mismatch repair and oxidative DNA damage: implications for cancer biology and treatment publication-title: Cancers doi: 10.3390/cancers6031597 – volume: 9 year: 2014 ident: 10.1016/j.dnarep.2019.03.013_bib0255 article-title: Single nucleotide polymorphisms in noncoding regions of Rad51C do not change the risk of unselected breast cancer but they modulate the level of oxidative stress and the DNA damage characteristics: a case-control study publication-title: PLoS One doi: 10.1371/journal.pone.0110696 – volume: 5 start-page: 349 year: 2012 ident: 10.1016/j.dnarep.2019.03.013_bib0160 article-title: Assessment scales in dementia publication-title: Ther. Adv. Neurol. Disord. doi: 10.1177/1756285612455733 – volume: 73 start-page: 98 year: 2016 ident: 10.1016/j.dnarep.2019.03.013_bib0075 article-title: Association between single-nucleotide polymorphisms of the hOGG1, NEIL1, APEX1, FEN1, LIG1, and LIG3 genes and Alzheimer’s disease risk publication-title: Neuropsychobiology doi: 10.1159/000444643 – volume: 7 start-page: 13589 year: 2017 ident: 10.1016/j.dnarep.2019.03.013_bib0165 article-title: Transforming growth factor-beta signaling pathway-associated genes SMAD2 and TGFBR2 are implicated in metabolic syndrome in a Taiwanese population publication-title: Sci. Rep. doi: 10.1038/s41598-017-14025-4 – volume: 31 start-page: 197 year: 2010 ident: 10.1016/j.dnarep.2019.03.013_bib0230 article-title: The most frequent DCLRE1C (ARTEMIS) mutations are based on homologous recombination events publication-title: Hum. Mutat. doi: 10.1002/humu.21168 – volume: 429 start-page: 883 year: 2004 ident: 10.1016/j.dnarep.2019.03.013_bib0025 article-title: Gene regulation and DNA damage in the ageing human brain publication-title: Nature doi: 10.1038/nature02661 – volume: 36 start-page: 1299 year: 2015 ident: 10.1016/j.dnarep.2019.03.013_bib0100 article-title: Interactions of DNA repair gene variants modulate chromosomal aberrations in healthy subjects publication-title: Carcinogenesis doi: 10.1093/carcin/bgv127 – volume: 24 start-page: 182 year: 2010 ident: 10.1016/j.dnarep.2019.03.013_bib0065 article-title: Evaluation of the poly (ADP‐ribose) polymerase‐1 gene variants in Alzheimer’s disease publication-title: J. Clin. Lab. Anal. doi: 10.1002/jcla.20379 – year: 2018 ident: 10.1016/j.dnarep.2019.03.013_bib0240 article-title: DNA methylation of telomere-related genes and Cancer risk publication-title: Cancer Prev. Res. doi: 10.1158/1940-6207.CAPR-17-0413 – volume: 168 start-page: 154 year: 2008 ident: 10.1016/j.dnarep.2019.03.013_bib0245 article-title: The association between physical activity in leisure time and leukocyte telomere length publication-title: Arch. Intern. Med. doi: 10.1001/archinternmed.2007.39 – volume: 25 start-page: 5321 year: 2016 ident: 10.1016/j.dnarep.2019.03.013_bib0155 article-title: Population structure of Han Chinese in the modern Taiwanese population based on 10,000 participants in the Taiwan Biobank project publication-title: Hum. Mol. Genet. – volume: 614 start-page: 24 year: 2007 ident: 10.1016/j.dnarep.2019.03.013_bib0040 article-title: DNA repair in neurons: so if they don’t divide what’s to repair? publication-title: Mutat. Res. Mol. Mech. Mutagen. doi: 10.1016/j.mrfmmm.2006.06.007 – volume: 9 start-page: 290 year: 2018 ident: 10.1016/j.dnarep.2019.03.013_bib0265 article-title: A deep learning approach for predicting antidepressant response in major depression using clinical and genetic biomarkers publication-title: Front. Psychiatry doi: 10.3389/fpsyt.2018.00290 – volume: 81 start-page: 559 year: 2007 ident: 10.1016/j.dnarep.2019.03.013_bib0180 article-title: PLINK: a tool set for whole-genome association and population-based linkage analyses publication-title: Am. J. Hum. Genet. doi: 10.1086/519795 – volume: 577 start-page: 275 year: 2005 ident: 10.1016/j.dnarep.2019.03.013_bib0120 article-title: Human DNA repair genes, 2005 publication-title: Mutat. Res. doi: 10.1016/j.mrfmmm.2005.03.007 – volume: 43 start-page: 119 year: 2017 ident: 10.1016/j.dnarep.2019.03.013_bib0140 article-title: The rs1277306 variant of the REST gene confers susceptibility to cognitive aging in an elderly Taiwanese population publication-title: Dement. Geriatr. Cogn. Disord. doi: 10.1159/000455833 – volume: 31 start-page: 12543 year: 2011 ident: 10.1016/j.dnarep.2019.03.013_bib0105 article-title: Accelerated age-related cognitive decline and neurodegeneration, caused by deficient DNA repair publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.1589-11.2011 – volume: 8 start-page: 24077 year: 2017 ident: 10.1016/j.dnarep.2019.03.013_bib0145 article-title: Association and interaction effects of Alzheimer’s disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population publication-title: Oncotarget doi: 10.18632/oncotarget.15269 – volume: 8 start-page: 24088 year: 2017 ident: 10.1016/j.dnarep.2019.03.013_bib0150 article-title: Effects of circadian clock genes and environmental factors on cognitive aging in old adults in a Taiwanese population publication-title: Oncotarget doi: 10.18632/oncotarget.15493 – volume: 8 start-page: 93349 year: 2017 ident: 10.1016/j.dnarep.2019.03.013_bib0260 article-title: Detection of susceptibility loci on APOA5 and COLEC12 associated with metabolic syndrome using a genome-wide association study in a Taiwanese population publication-title: Oncotarget doi: 10.18632/oncotarget.20967 – volume: 380 start-page: 442 year: 2016 ident: 10.1016/j.dnarep.2019.03.013_bib0090 article-title: Genetic variation in the major mitotic checkpoint genes associated with chromosomal aberrations in healthy humans publication-title: Cancer Lett. doi: 10.1016/j.canlet.2016.07.011 – volume: 71 start-page: 176 year: 2015 ident: 10.1016/j.dnarep.2019.03.013_bib0070 article-title: Variants of base excision repair genes MUTYH, PARP1 and XRCC1 in Alzheimer’s disease risk publication-title: Neuropsychobiology doi: 10.1159/000381985 |
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| Snippet | •The EXO1 rs1776181, rs1776177, rs1635510, and rs2526698 SNPs are associated with cognitive aging.•Interactions between the EXO1 gene and physical activity... Evidence indicates that the age-related neuropathological mechanisms associated with DNA repair genes may contribute to cognitive aging and Alzheimer's... |
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| StartPage | 1 |
| SubjectTerms | Aged Alzheimer’s diseases Cognitive Aging Cognitive impairment DNA Repair - genetics DNA Repair Enzymes - genetics Exodeoxyribonucleases - genetics Female Gene-gene interactions Genotype Humans Male Middle Aged Neurodegeneration Polymorphism, Single Nucleotide Single nucleotide polymorphisms Taiwan |
| Title | Polymorphisms of the DNA repair gene EXO1 modulate cognitive aging in old adults in a Taiwanese population |
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