The effect of overexpression of PGC-1α on the mtDNA4834 common deletion in a rat cochlear marginal cell senescence model

• Published in: Hearing research Vol. 296; pp. 13 - 24
• Main Authors: Zhao, Xue-Yan, Sun, Jin-Li, Hu, Yu-Juan, Yang, Yang, Zhang, Wen-Juan, Hu, Yuan, Li, Jun, Sun, Yu, Zhong, Yi, Peng, Wei, Zhang, Hong-Lian, Kong, Wei-Jia
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.02.2013
• Subjects: Adenoviridae - genetics; Animals; Animals, Newborn; Apoptosis; Cells, Cultured; Cellular Senescence - drug effects; Cellular Senescence - genetics; Cochlea - drug effects; Cochlea - metabolism; Cochlea - pathology; DNA, Mitochondrial - genetics; Dose-Response Relationship, Drug; Galactose - pharmacology; Genetic Predisposition to Disease; Genetic Vectors; NF-kappa B - metabolism; Nuclear Respiratory Factor 1 - metabolism; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Phenotype; Presbycusis - genetics; Presbycusis - metabolism; Presbycusis - pathology; Rats; Rats, Sprague-Dawley; RNA-Binding Proteins - genetics; RNA-Binding Proteins - metabolism; Sequence Deletion; Time Factors; Transcription Factors - genetics; Transcription Factors - metabolism; Transfection; Up-Regulation; CD; NF-κB; SA-β-gal; LSCM; TUNEL; AHL; NRF-1; Tfam; PGC-1α; EP; MCs

Aging is a natural process usually defined as a progressive loss of function with an accumulation of senescent cells. The clinical manifestations of this process include age-related hearing loss (AHL)/presbycusis. Several investigations indicated the association between a mitochondrial common deleti...