TGR5-mediated lateral hypothalamus-dCA3-dorsolateral septum circuit regulates depressive-like behavior in male mice

• Published in: Neuron (Cambridge, Mass.) Vol. 112; no. 11; pp. 1795 - 1814.e10
• Main Authors: Li, Xu-Yi, Zhang, Shi-Ya, Hong, Yi-Zhou, Chen, Zhi-Gang, Long, Yan, Yuan, Dan-Hua, Zhao, Jia-Jia, Tang, Su-Su, Wang, Hao, Hong, Hao
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 05.06.2024
• Subjects: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism; CaMKIIα neuron; Depression - metabolism; depressive-like behavior; Disease Models, Animal; dorsal CA3; dorsolateral septum; GABAergic neuron; GABAergic Neurons - metabolism; GABAergic Neurons - physiology; Hypothalamic Area, Lateral - metabolism; Kv4.2 channel; lateral hypothalamus; Male; Mice; Mice, Inbred C57BL; Neural Pathways - metabolism; Receptors, G-Protein-Coupled - genetics; Receptors, G-Protein-Coupled - metabolism; Septal Nuclei - metabolism; Social Defeat; Stress, Psychological - metabolism; TGR5; triple circuit; CaMKIIα neuron; TGR5; lateral hypothalamus; GABAergic neuron; triple circuit; dorsal CA3; Kv4.2 channel; depressive-like behavior; dorsolateral septum

Although bile acids play a notable role in depression, the pathological significance of the bile acid TGR5 membrane-type receptor in this disorder remains elusive. Using depression models of chronic social defeat stress and chronic restraint stress in male mice, we found that TGR5 in the lateral hyp...