Photosensitizing metal–organic framework nanoparticles combined with tumor-sensitization strategies can enhance the phototherapeutic effect upon medullary thyroid carcinoma

• Published in: Biochimica et biophysica acta. General subjects Vol. 1868; no. 12; p. 130725
• Main Authors: Feng, Yingqi, Jiang, Qiyu, Ma, Xue, Sun, Huiwei, Chai, Yantao, Li, Xiaojuan, Wang, Zhijie, Feng, Fan
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2024
• Subjects: Animals; Benzamides; Carcinoma, Neuroendocrine - drug therapy; Carcinoma, Neuroendocrine - metabolism; Carcinoma, Neuroendocrine - pathology; Cell Line, Tumor; Drug delivery; Female; Humans; Indoles - chemistry; Indoles - pharmacology; Medullary thyroid carcinoma; Metal-organic frameworks; Metal-Organic Frameworks - chemistry; Metal-Organic Frameworks - pharmacology; Mice; Mice, Nude; Morpholines; Nanoparticles - chemistry; Photochemotherapy - methods; Photodynamic therapy; Photosensitizing Agents - pharmacology; Pyrimidines; Thyroid Neoplasms - drug therapy; Thyroid Neoplasms - metabolism; Thyroid Neoplasms - pathology; Thyroid Neoplasms - therapy; Tumor sensitizer; Xenograft Model Antitumor Assays; Tumor sensitizer; Drug delivery; Photodynamic therapy; Metal-organic frameworks; Medullary thyroid carcinoma

Photodynamic therapy (PDT) utilizing metal-organic frameworks (MOFs) has developed as a new and efficacious treatment for malignant tumors located on the surface of the human body. In order to achieve more effective PDT treatment outcomes, the traditional method has been to increase the intensity of...