Absolute configuration of polypropionate derivatives: Decempyrones A–J and their MptpA inhibition and anti-inflammatory activities

• Published in: Bioorganic chemistry Vol. 115; pp. 105156 - 105165
• Main Authors: Guo, Heng, Wu, Qilin, Chen, Dongni, Jiang, Minghua, Chen, Bin, Lu, Yongjun, Li, Jing, Liu, Lan, Chen, Senhua
• Format: Journal Article
• Language: English
• Published: SAN DIEGO Elsevier Inc 01.10.2021; Elsevier
• Subjects: Animals; Anti-inflammatory; Anti-Inflammatory Agents - chemistry; Anti-Inflammatory Agents - isolation & purification; Anti-Inflammatory Agents - pharmacology; Bacterial Proteins - antagonists & inhibitors; Bacterial Proteins - metabolism; Biochemistry & Molecular Biology; Chemistry; Chemistry, Organic; Fusarium; Fusarium - chemistry; Fusarium - metabolism; Life Sciences & Biomedicine; Lipopolysaccharides - pharmacology; Macrophages - cytology; Macrophages - drug effects; Macrophages - metabolism; Magnetic Resonance Spectroscopy; Marine fungi; Mice; Molecular Conformation; MptpA inhibitor; Nitric Oxide - metabolism; Physical Sciences; Polypropionate; Propionates - chemistry; Propionates - isolation & purification; Propionates - pharmacology; Protein Tyrosine Phosphatases - antagonists & inhibitors; Protein Tyrosine Phosphatases - metabolism; RAW 264.7 Cells; Science & Technology; MptpA inhibitor; Fusarium; Marine fungi; Polypropionate; Anti-inflammatory; MANGROMICINS; TYROSINE-PHOSPHATASE B; IDENTIFICATION

[Display omitted] •Ten new polypropionate derivatives, decempyrones A–J (1–10) were isolated from Fusarium graminearum.•Absolute configurations were fixed by JBCA, chemical degradation, geminal proton rule, and modified Mosher’s method.•Decempyrones C and J exhibited potent anti-inflammatory activit...