SAP(E) – A cell-penetrating polyproline helix at lipid interfaces

• Published in: Biochimica et biophysica acta Vol. 1858; no. 9; pp. 2028 - 2034
• Main Authors: Franz, Johannes, Lelle, Marco, Peneva, Kalina, Bonn, Mischa, Weidner, Tobias
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.09.2016
• Subjects: Cell-penetrating peptide; Cell-Penetrating Peptides - chemistry; Lipid Bilayers - chemistry; Models, Chemical; Peptide-membrane interaction; Peptides - chemistry; Polyproline; Protein Structure, Secondary; Static Electricity; Sum frequency generation; Peptide-membrane interaction; Sum frequency generation; Polyproline; Cell-penetrating peptide

Cell-penetrating peptides (CPPs) are short membrane-permeating amino acid sequences that can be used to deliver cargoes, e.g. drugs, into cells. The mechanism for CPP internalization is still subject of ongoing research. An interesting family of CPPs is the sweet arrow peptides – SAP(E) – which are...