Dose-responsive effects of endothelial cell-sourced exosomes on vascular cell proliferation and phenotype transition

• Published in: Biochimica et biophysica acta. General subjects Vol. 1869; no. 2; p. 130745
• Main Authors: Xiao, Yangyang, Zou, Dan, Liu, Jianan, Dai, Fanfan, Zhao, Ansha, Yang, Ping
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.02.2025
• Subjects: Animals; Atherosclerosis; Atherosclerosis - metabolism; Atherosclerosis - pathology; Cell Movement; Cell Proliferation; Cells, Cultured; Endothelial cell; Endothelial Cells - cytology; Endothelial Cells - metabolism; Exosome; Exosomes - metabolism; Human Umbilical Vein Endothelial Cells - metabolism; Humans; Macrophage; Macrophages - cytology; Macrophages - metabolism; Myocytes, Smooth Muscle - cytology; Myocytes, Smooth Muscle - metabolism; Nitric Oxide - metabolism; Phenotype; Smooth muscle cell; Smooth muscle cell; Endothelial cell; Exosome; Atherosclerosis; Macrophage

Endothelial cell-sourced exosomes are potential participants in the process of atherosclerosis, and their function is mainly affected by concentration. By studying the effects of exosome concentrations on vascular cells, atherosclerosis can be better intervened. In this study, exosomes with concentr...