Mixed-ligand Cu(II) hydrazone complexes designed to enhance anticancer activity

• Published in: European journal of medicinal chemistry Vol. 156; pp. 368 - 380
• Main Authors: Mo, QingYou, Deng, JunGang, Liu, Yani, Huang, GuiDong, Li, ZuoWen, Yu, Ping, Gou, Yi, Yang, Feng
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 05.08.2018
• Subjects: Anticancer activity; Anticancer mechanism; Mixed-ligand copper(II) complexes; Spheroid assay; Spheroid assay; Anticancer mechanism; Mixed-ligand copper(II) complexes; Anticancer activity

The ligand quantity, ligand type, and coordination geometry have important influences on the anticancer activity of metal-based complexes. On the basis of the structures of previously reported 1:1 Cu(II)/ligand complexes ([Cu(L1)Cl]·2H2O 1a, [Cu(L2)Cl]·H2O 2a, and [Cu(L2)NO3]·H2O 3a), we subsequentl...