In vitro and in vivo generation of heterophil extracellular traps after Salmonella exposure

• Published in: Veterinary immunology and immunopathology Vol. 188; pp. 1 - 11
• Main Authors: Pieper, Jana, Locke, Maria, Ruzaike, Gunda, Voigt, Stefanie, Methner, Ulrich, Berndt, Angela
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.06.2017
• Subjects: Animals; Chicken; Chickens - immunology; Chickens - microbiology; Extracellular traps; Extracellular Traps - metabolism; Granulocytes - immunology; Granulocytes - ultrastructure; Heterophil; Microscopy - veterinary; Microscopy, Confocal - veterinary; Microscopy, Fluorescence - veterinary; Poultry Diseases - immunology; Poultry Diseases - microbiology; Salmonella; Salmonella enterica - immunology; Salmonella enteritidis - immunology; Salmonella Infections, Animal - immunology; Heterophil; Salmonella; Chicken; Extracellular traps

The release of extracellular traps (ETs) by granulocytes is a unique strategy to stop the dissemination of microbial pathogens. This study was undertaken to elucidate the potential of avian granulocytes (heterophils) to form ETs that can arrest and kill Salmonella organisms. After in vitro exposure...