The intrinsic flexibility of the aptamer targeting the ribosomal protein S8 is a key factor for the molecular recognition

• Published in: Biochimica et biophysica acta Vol. 1862; no. 4; pp. 1006 - 1016
• Main Authors: Autiero, Ida, Ruvo, Menotti, Improta, Roberto, Vitagliano, Luigi
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.04.2018
• Subjects: Aptamer conformational flexibility; Molecular dynamics; Population shift mechanism; Protein-nucleic acid recognition; Ribosomal proteins; Population shift mechanism; IL; APT; H-bonds; Molecular dynamics; RMSD; Aptamer conformational flexibility; PDB; 400APTbound; Ribosomal proteins; APTbound; MD; RMSIP; TL; APT-S8compl; APTfree; Protein-nucleic acid recognition; APTbound/free; SELEX

Aptamers are RNA/DNA biomolecules representing an emerging class of protein interactors and regulators. Despite the growing interest in these molecules, current understanding of chemical-physical basis of their target recognition is limited. Recently, the characterization of the aptamer targeting th...