Steroid-Induced Hyperglycemia and Its Effect on Outcomes of R-CHOP Chemotherapy for Diffuse Large B-Cell Lymphoma

• Published in: Current oncology (Toronto) Vol. 30; no. 12; pp. 10142 - 10151
• Main Authors: Kristjanson, Mark, Lambert, Pascal, Decker, Kathleen M., Bruin, Sonja, Tingey, Elizabeth, Skrabek, Pamela
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 28.11.2023
• Subjects: Antibodies, Monoclonal, Murine-Derived - adverse effects; Antineoplastic Combined Chemotherapy Protocols - adverse effects; Humans; hyperglycemia; Hyperglycemia - chemically induced; Hyperglycemia - drug therapy; lymphoma; Lymphoma, Large B-Cell, Diffuse - drug therapy; Prednisone - adverse effects; Retrospective Studies; steroid; toxicities; hyperglycemia; toxicities; lymphoma; steroid

Large doses of steroids are integral to R-CHOP, a first-line systemic therapy for diffuse large B-cell lymphoma (DLBCL), an aggressive form of non-Hodgkin Lymphoma (NHL). Patients on R-CHOP often develop clinically significant hyperglycemia from steroids. There is evidence of harms from steroid-indu...