Differential chamber-specific expression and regulation of long non-coding RNAs during cardiac development

• Published in: Biochimica et biophysica acta. Gene regulatory mechanisms Vol. 1862; no. 10; p. 194435
• Main Authors: García-Padilla, Carlos, Domínguez, Jorge N., Aránega, Amelia E., Franco, Diego
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.10.2019
• Subjects: Animals; Cardiovascular System - growth & development; Cardiovascular System - metabolism; Cell Differentiation - genetics; Gene Expression Regulation, Developmental - genetics; Heart - growth & development; Homeobox Protein Nkx-2.5 - genetics; Homeobox Protein PITX2; Homeodomain Proteins - genetics; In Situ Hybridization; MEF2 Transcription Factors - genetics; Mice; Mice, Knockout; MicroRNAs - genetics; RNA, Long Noncoding - genetics; Serum Response Factor - genetics; Transcription Factors - genetics

Cardiovascular development is governed by a complex interplay between inducting signals such as Bmps and Fgfs leading to activation of cardiac specific transcription factors such as Nkx2.5, Mef2c and Srf that orchestrate the initial steps of cardiogenesis. Over the last decade we have witnessed the...