Chronic sigma-1 receptor activation ameliorates ventricular remodeling and decreases susceptibility to ventricular arrhythmias after myocardial infarction in rats

• Published in: European journal of pharmacology Vol. 889; p. 173614
• Main Authors: Fo, Yuhong, Zhang, Cui, Chen, Xiuhuan, Liu, Xin, Ye, Tianxin, Guo, Yan, Qu, Chuan, Shi, Shaobo, Yang, Bo
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.12.2020
• Subjects: Animals; Drug Administration Schedule; Fluvoxamine; Fluvoxamine - administration & dosage; Male; Myocardial infarction; Myocardial Infarction - complications; Myocardial Infarction - drug therapy; Myocardial Infarction - metabolism; Rats; Rats, Sprague-Dawley; Receptors, sigma - agonists; Receptors, sigma - metabolism; Sigma-1 Receptor; Ventricular arrhythmia; Ventricular Fibrillation - etiology; Ventricular Fibrillation - metabolism; Ventricular Fibrillation - prevention & control; Ventricular remodeling; Ventricular Remodeling - drug effects; Ventricular Remodeling - physiology; Myocardial infarction; Ventricular arrhythmia; Ventricular remodeling; Sigma-1 receptor; Fluvoxamine

The present study aimed to assess the effect of sigma-1 receptor (S1R) stimulation on ventricular remodeling and susceptibility to ventricular arrhythmias (VAs) after myocardial infarction (MI) in rats. Wild-type male rats were placed into one of the following four treatment groups. For four weeks,...