Neuroprotection of Chikusetsu saponin V on transient focal cerebral ischemia/reperfusion and the underlying mechanism
Oxidative stress and frequently unwanted alterations in mitochondrial structure and function are key aspects of the pathological cascade in transient focal cerebral ischemia. Chikusetsu saponin V (CHS V), a major component of saponins from Panax japonicas, can attenuate H2O2-induced oxidative stress...
Saved in:
| Published in | Phytomedicine (Stuttgart) Vol. 84; p. 153516 |
|---|---|
| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Germany
Elsevier GmbH
01.04.2021
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Oxidative stress and frequently unwanted alterations in mitochondrial structure and function are key aspects of the pathological cascade in transient focal cerebral ischemia. Chikusetsu saponin V (CHS V), a major component of saponins from Panax japonicas, can attenuate H2O2-induced oxidative stress in SH-SY5Y cells.
The aim of the present study was to investigate the neuroprotective effects and the possible underlying mechanism of CHS V on transient focal cerebral ischemia/reperfusion.
Mice with middle cerebral artery occlusion (MCAO) and cultured cortical neurons exposed to oxygen glucose deprivation (OGD) were used as in vivo and in vitro models of cerebral ischemia, respectively. The neurobehavioral scores, infarction volumes, H&E staining and some antioxidant levels in the brain were evaluated. The occurrence of neuronal death was estimated. Total and mitochondrial reactive oxygen species (ROS) levels, as well as mitochondrial potential were measured using flow cytometry analysis. Mitochondrial structure and respiratory activity were also examined. Protein levels were investigated by western blotting and immunohistochemistry.
CHS V effectively attenuated cerebral ischemia/reperfusion (CI/R) injury, including improving neurological deficits, shrinking infarct volume and reducing the number of apoptotic cells. Furthermore, CHS V treatment remarkably increased antioxidant levels and reduced ROS levels and mitochondrial damage by enhancing the expression and deacetylation of peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) by activating AMPK and SIRT-1, respectively.
Our data demonstrated that CHS V prevented CI/R injury by suppressing oxidative stress and mitochondrial damage through the modulation of PGC-1α with AMPK and SIRT-1. |
|---|---|
| AbstractList | BACKGROUNDOxidative stress and frequently unwanted alterations in mitochondrial structure and function are key aspects of the pathological cascade in transient focal cerebral ischemia. Chikusetsu saponin V (CHS V), a major component of saponins from Panax japonicas, can attenuate H2O2-induced oxidative stress in SH-SY5Y cells.PURPOSEThe aim of the present study was to investigate the neuroprotective effects and the possible underlying mechanism of CHS V on transient focal cerebral ischemia/reperfusion.METHODSMice with middle cerebral artery occlusion (MCAO) and cultured cortical neurons exposed to oxygen glucose deprivation (OGD) were used as in vivo and in vitro models of cerebral ischemia, respectively. The neurobehavioral scores, infarction volumes, H&E staining and some antioxidant levels in the brain were evaluated. The occurrence of neuronal death was estimated. Total and mitochondrial reactive oxygen species (ROS) levels, as well as mitochondrial potential were measured using flow cytometry analysis. Mitochondrial structure and respiratory activity were also examined. Protein levels were investigated by western blotting and immunohistochemistry.RESULTSCHS V effectively attenuated cerebral ischemia/reperfusion (CI/R) injury, including improving neurological deficits, shrinking infarct volume and reducing the number of apoptotic cells. Furthermore, CHS V treatment remarkably increased antioxidant levels and reduced ROS levels and mitochondrial damage by enhancing the expression and deacetylation of peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) by activating AMPK and SIRT-1, respectively.CONCLUSIONOur data demonstrated that CHS V prevented CI/R injury by suppressing oxidative stress and mitochondrial damage through the modulation of PGC-1α with AMPK and SIRT-1. Oxidative stress and frequently unwanted alterations in mitochondrial structure and function are key aspects of the pathological cascade in transient focal cerebral ischemia. Chikusetsu saponin V (CHS V), a major component of saponins from Panax japonicas, can attenuate H O -induced oxidative stress in SH-SY5Y cells. The aim of the present study was to investigate the neuroprotective effects and the possible underlying mechanism of CHS V on transient focal cerebral ischemia/reperfusion. Mice with middle cerebral artery occlusion (MCAO) and cultured cortical neurons exposed to oxygen glucose deprivation (OGD) were used as in vivo and in vitro models of cerebral ischemia, respectively. The neurobehavioral scores, infarction volumes, H&E staining and some antioxidant levels in the brain were evaluated. The occurrence of neuronal death was estimated. Total and mitochondrial reactive oxygen species (ROS) levels, as well as mitochondrial potential were measured using flow cytometry analysis. Mitochondrial structure and respiratory activity were also examined. Protein levels were investigated by western blotting and immunohistochemistry. CHS V effectively attenuated cerebral ischemia/reperfusion (CI/R) injury, including improving neurological deficits, shrinking infarct volume and reducing the number of apoptotic cells. Furthermore, CHS V treatment remarkably increased antioxidant levels and reduced ROS levels and mitochondrial damage by enhancing the expression and deacetylation of peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) by activating AMPK and SIRT-1, respectively. Our data demonstrated that CHS V prevented CI/R injury by suppressing oxidative stress and mitochondrial damage through the modulation of PGC-1α with AMPK and SIRT-1. Oxidative stress and frequently unwanted alterations in mitochondrial structure and function are key aspects of the pathological cascade in transient focal cerebral ischemia. Chikusetsu saponin V (CHS V), a major component of saponins from Panax japonicas, can attenuate H2O2-induced oxidative stress in SH-SY5Y cells. The aim of the present study was to investigate the neuroprotective effects and the possible underlying mechanism of CHS V on transient focal cerebral ischemia/reperfusion. Mice with middle cerebral artery occlusion (MCAO) and cultured cortical neurons exposed to oxygen glucose deprivation (OGD) were used as in vivo and in vitro models of cerebral ischemia, respectively. The neurobehavioral scores, infarction volumes, H&E staining and some antioxidant levels in the brain were evaluated. The occurrence of neuronal death was estimated. Total and mitochondrial reactive oxygen species (ROS) levels, as well as mitochondrial potential were measured using flow cytometry analysis. Mitochondrial structure and respiratory activity were also examined. Protein levels were investigated by western blotting and immunohistochemistry. CHS V effectively attenuated cerebral ischemia/reperfusion (CI/R) injury, including improving neurological deficits, shrinking infarct volume and reducing the number of apoptotic cells. Furthermore, CHS V treatment remarkably increased antioxidant levels and reduced ROS levels and mitochondrial damage by enhancing the expression and deacetylation of peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) by activating AMPK and SIRT-1, respectively. Our data demonstrated that CHS V prevented CI/R injury by suppressing oxidative stress and mitochondrial damage through the modulation of PGC-1α with AMPK and SIRT-1. |
| ArticleNumber | 153516 |
| Author | Zhang, Tiejun Shan, Tikun Li, Zhengjun Jia, Jing Li, Yuwen Fang, Yuan Qin, Zhou Tang, Linqiao Jia, Na Cao, Yi Jin, Zhaohui Xu, Ting |
| Author_xml | – sequence: 1 givenname: Tiejun surname: Zhang fullname: Zhang, Tiejun organization: Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu 610041, China – sequence: 2 givenname: Zhengjun surname: Li fullname: Li, Zhengjun organization: Department of Dermatology, Qilu Hospital, Shandong University, Jinan 250012, China – sequence: 3 givenname: Zhou surname: Qin fullname: Qin, Zhou organization: Department of Pharmacy, West China Hospital, Sichuan University, Chengdu 610041, China – sequence: 4 givenname: Yi surname: Cao fullname: Cao, Yi organization: Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu 610041, China – sequence: 5 givenname: Tikun surname: Shan fullname: Shan, Tikun organization: Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu 610041, China – sequence: 6 givenname: Yuan surname: Fang fullname: Fang, Yuan organization: Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu 610041, China – sequence: 7 givenname: Linqiao surname: Tang fullname: Tang, Linqiao organization: Core Facility, West China Hospital, Sichuan University, Chengdu 610041, China – sequence: 8 givenname: Na surname: Jia fullname: Jia, Na organization: West China School of Pharmacy, Sichuan University, Chengdu 610041, China – sequence: 9 givenname: Jing orcidid: 0000-0001-7460-0306 surname: Jia fullname: Jia, Jing organization: Department of Pharmacy, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250014, China – sequence: 10 givenname: Zhaohui surname: Jin fullname: Jin, Zhaohui organization: Core Facility, West China Hospital, Sichuan University, Chengdu 610041, China – sequence: 11 givenname: Ting surname: Xu fullname: Xu, Ting organization: Department of Pharmacy, West China Hospital, Sichuan University, Chengdu 610041, China – sequence: 12 givenname: Yuwen surname: Li fullname: Li, Yuwen email: zgsd.lyw@hotmail.com, liyuwenzs@gmail.com organization: Department of Pharmacy, West China Hospital, Sichuan University, Chengdu 610041, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33639592$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kE1v1DAQhi1URLeFf4CQj1yy9Ve88QUJrcqHVMEFEDfLsSfES2IHO0baf49Xaa-cZqR5531nnht0FWIAhF5TsqeEyrvTfhnPM7g9I4zuactbKp-hHZW0a4hqf16hHVFCNAdK-TW6yflECBXqQF6ga84lV61iO1S-QElxSXEFu_oYcBzwcfS_S4Y1F5zNEoMP-AeuozWZkD2EFQ_RmglbSNCn2vhsR5i9uUuwQBpKvhiZ4PA6Ai7BQZrOPvzCM9jRBJ_nl-j5YKYMrx7rLfr-4f7b8VPz8PXj5-P7h8ZyydbmQFRHCDGkF70VsiXUmcG5jkuorZSSDm3fcUvZgXWDUB03jnA5UMsVlb3gt-jt5lsf_FMgr3qut8I0mQCxZM2EEqxTrWRVKjapTTHnBINekp9NOmtK9AW4PukNuL4A1xvwuvbmMaH0l9nT0hPhKni3CaD--ddD0tlWhhacTxW5dtH_P-EfsmiXFg |
| CitedBy_id | crossref_primary_10_1016_j_brainres_2022_148096 crossref_primary_10_1016_j_phymed_2022_154224 crossref_primary_10_1186_s10020_022_00477_6 crossref_primary_10_1016_j_biopha_2022_113696 crossref_primary_10_1177_09731296241259807 crossref_primary_10_3389_fphar_2023_1220862 crossref_primary_10_1155_2022_8202975 |
| Cites_doi | 10.3390/ijms150813209 10.1038/nature03354 10.1152/japplphysiol.00349.2003 10.1016/j.ijbiomac.2011.12.023 10.1152/ajpcell.00222.2006 10.1111/jphp.12291 10.1093/alcalc/agq034 10.1161/CIRCULATIONAHA.109.864629 10.1007/s12035-012-8344-z 10.1101/gad.1295005 10.1016/j.cell.2006.11.013 10.1080/15216540051081056 10.1016/j.neures.2006.04.005 10.1111/jnc.14583 10.1139/cjpp-2015-0262 10.4103/bc.bc_14_18 10.1177/0271678X19846657 10.1016/j.jep.2011.12.024 10.1055/s-2005-916176 10.1074/jbc.M109.055301 10.1007/s12035-016-0173-z 10.1111/j.1749-6632.2012.06738.x 10.1007/s13105-017-0576-y 10.3390/ijms12107199 10.1073/pnas.0705070104 |
| ContentType | Journal Article |
| Copyright | 2021 Elsevier GmbH Copyright © 2021 Elsevier GmbH. All rights reserved. |
| Copyright_xml | – notice: 2021 Elsevier GmbH – notice: Copyright © 2021 Elsevier GmbH. All rights reserved. |
| DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 |
| DOI | 10.1016/j.phymed.2021.153516 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Pharmacy, Therapeutics, & Pharmacology |
| EISSN | 1618-095X |
| EndPage | 153516 |
| ExternalDocumentID | 10_1016_j_phymed_2021_153516 33639592 S0944711321000581 |
| Genre | Journal Article |
| GroupedDBID | --- --K --M .~1 0R~ 123 1B1 1~. 1~5 29O 3V. 4.4 457 4G. 53G 5VS 7-5 71M 7RV 7X2 7X7 88E 88I 8AF 8FE 8FH 8FI 8FJ 8P~ 8R4 8R5 9JM AABNK AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AAKPP AALRI AAOAW AAQFI AAQXK AATCM AAWTL AAXUO AAYOK ABBQC ABFNM ABFRF ABGSF ABJNI ABLVK ABMAC ABMZM ABUDA ABUWG ABXDB ABYKQ ABZDS ACDAQ ACGFO ACGFS ACGOD ACRLP ADBBV ADEZE ADMUD ADUVX AEBSH AEFWE AEHWI AEKER AENEX AFKRA AFKWA AFRAH AFTJW AFXIZ AGHFR AGRDE AGUBO AGYEJ AHHHB AHMBA AIEXJ AIKHN AITUG AIXEN AJBFU AJOXV AJRQY ALCLG ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ANZVX ASPBG ATCPS AVWKF AXJTR AZFZN AZQEC BENPR BES BHPHI BKEYQ BKOJK BLXMC BNPGV BPHCQ BVXVI CAG CCPQU COF CS3 DOVZS DU5 DWQXO EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 EX3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN FYUFA G-Q GBLVA GNUQQ HCIFZ HMCUK HVGLF HX~ HZ~ IAG IAO IEA IHA IHE IHR INH INR IOF ISR J1W KOM LCYCR M0K M1P M2P M2Q M41 MO0 N9A NAPCQ O-L O9- OAUVE OGGZJ OZT P-8 P-9 P2P PC. PCD PQQKQ PROAC PSQYO PV9 Q2X Q38 R2- RIG ROL RPZ RWL RXW RZL S0X SCC SDF SDG SEL SES SEW SPCBC SSH SSP SSU SSZ T5I T5K TAE UKHRP UNMZH WOW ~G- ~KM AAHBH AAXKI AFJKZ AKRWK ALIPV CGR CUY CVF ECM EIF ITC NPM AAYXX CITATION 7X8 |
| ID | FETCH-LOGICAL-c362t-7098000a0b4bc46501dafdd836e01d6661f5b83c12728f4983ad036f1c3916b43 |
| IEDL.DBID | AIKHN |
| ISSN | 0944-7113 |
| IngestDate | Fri Oct 25 03:49:18 EDT 2024 Thu Sep 26 15:51:18 EDT 2024 Sat Nov 02 12:08:23 EDT 2024 Fri Feb 23 02:47:12 EST 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | MCAO Neuroprotection Oxidative stress Mitochondrial damages Chikusetsu saponin V mtDNA H&E PGC-1α SPJ OGD DMEM SIRT-1 FITC mNSS TUNEL CI/R CHS V AMPK PI PJ Transient focal cerebral ischemia/reperfusion |
| Language | English |
| License | Copyright © 2021 Elsevier GmbH. All rights reserved. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c362t-7098000a0b4bc46501dafdd836e01d6661f5b83c12728f4983ad036f1c3916b43 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ORCID | 0000-0001-7460-0306 |
| PMID | 33639592 |
| PQID | 2494289562 |
| PQPubID | 23479 |
| PageCount | 1 |
| ParticipantIDs | proquest_miscellaneous_2494289562 crossref_primary_10_1016_j_phymed_2021_153516 pubmed_primary_33639592 elsevier_sciencedirect_doi_10_1016_j_phymed_2021_153516 |
| PublicationCentury | 2000 |
| PublicationDate | April 2021 2021-Apr 2021-04-00 20210401 |
| PublicationDateYYYYMMDD | 2021-04-01 |
| PublicationDate_xml | – month: 04 year: 2021 text: April 2021 |
| PublicationDecade | 2020 |
| PublicationPlace | Germany |
| PublicationPlace_xml | – name: Germany |
| PublicationTitle | Phytomedicine (Stuttgart) |
| PublicationTitleAlternate | Phytomedicine |
| PublicationYear | 2021 |
| Publisher | Elsevier GmbH |
| Publisher_xml | – name: Elsevier GmbH |
| References | Wan, Deng, Zhang, Yuan, Liu, Dun, Zhou, Zhao, Liu, Yuan, Wang (bib0022) 2016; 94 Menghini, Casagrande, Cardellini, Martelli, Terrinoni, Amati, Vasa-Nicotera, Ippoliti, Novelli, Melino, Lauro, Federici (bib0015) 2009; 120 Hosono-Nishiyama, Matsumoto, Kiyohara, Nishizawa, Atsumi, Yamada (bib0005) 2006; 72 Jager, Handschin, St-Pierre, Spiegelman (bib0007) 2007; 104 Suwa, Nakano, Kumagai (bib0019) 2003; 95 Levine, Moskovitz, Stadtman (bib0011) 2000; 50 Thirupathi, de Souza (bib0021) 2017; 73 Wei, Zhang, He, Wang, Liu, Liu, Sun, Zhou, Bai, Yuan (bib0025) 2014; 66 Baker, Balu, He, Kavuri, Busch, Amendolia, Quattrone, Frangos, Maloney-Wilensky, Abramson, Mahanna Gabrielli, Yodh, Andrew Kofke (bib0001) 2019; 39 Kann, Kovacs (bib0009) 2007; 292 Liu, Liu, Zhang, Liu, Xu, Mu, Ren, Jia, Li, Ding, Wen, Li (bib0014) 2018; 147 Lagouge, Argmann, Gerhart-Hines, Meziane, Lerin, Daussin, Messadeq, Milne, Lambert, Elliott, Geny, Laakso, Puigserver, Auwerx (bib0010) 2006; 127 Teyssier, Ma, Emter, Kralli, Stallcup (bib0020) 2005; 19 Iijima (bib0006) 2006; 55 Chen, Yang, Lin, Shaw, Liou, Chuang (bib0002) 2011; 12 He, Xu, Xu, Zhang, Wang, He, Wang, Yuan (bib0004) 2012; 140 Rodgers, Lerin, Haas, Gygi, Spiegelman, Puigserver (bib0016) 2005; 434 Wang, Chen, Jia, Tang, Ma (bib0024) 2012; 50 Kang, Li Ji (bib0008) 2012; 1271 Yuan, Wan, Deng, Zhang, Dun, Dai, Zhou, Liu, Wang (bib0027) 2014; 15 Go, Mozaffarian, Roger, Benjamin, Berry, Borden, Bravata, Dai, Ford, Fox, Franco, Fullerton, Gillespie, Hailpern, Heit, Howard, Huffman, Kissela, Kittner, Lackland, Lichtman, Lisabeth, Magid, Marcus, Marelli, Matchar, McGuire, Mohler, Moy, Mussolino, Nichol, Paynter, Schreiner, Sorlie, Stein, Turan, Virani, Wong, Woo, Turner (bib0003) 2013; 127 Li, Ji, Zhong, Shi, Hu, Chen (bib0012) 2010; 45 Sanderson, Reynolds, Kumar, Przyklenk, Huttemann (bib0018) 2013; 47 Liu, Murphy (bib0013) 2009; 284 Wan, Wang, Zhou, Deng, Zhang, Liu, Zhao, Wang, Yuan, He, Dun, Yuan, Wang (bib0023) 2019 Xie, Zhang, Tian, Chen (bib0026) 2017; 54 Russo, Nguyen, Lippert, Tuazon, Borlongan, Napoli (bib0017) 2018; 4 He (10.1016/j.phymed.2021.153516_bib0004) 2012; 140 Xie (10.1016/j.phymed.2021.153516_bib0026) 2017; 54 Wan (10.1016/j.phymed.2021.153516_bib0023) 2019 Thirupathi (10.1016/j.phymed.2021.153516_bib0021) 2017; 73 Hosono-Nishiyama (10.1016/j.phymed.2021.153516_bib0005) 2006; 72 Teyssier (10.1016/j.phymed.2021.153516_bib0020) 2005; 19 Lagouge (10.1016/j.phymed.2021.153516_bib0010) 2006; 127 Russo (10.1016/j.phymed.2021.153516_bib0017) 2018; 4 Wei (10.1016/j.phymed.2021.153516_bib0025) 2014; 66 Baker (10.1016/j.phymed.2021.153516_bib0001) 2019; 39 Chen (10.1016/j.phymed.2021.153516_bib0002) 2011; 12 Jager (10.1016/j.phymed.2021.153516_bib0007) 2007; 104 Levine (10.1016/j.phymed.2021.153516_bib0011) 2000; 50 Sanderson (10.1016/j.phymed.2021.153516_bib0018) 2013; 47 Iijima (10.1016/j.phymed.2021.153516_bib0006) 2006; 55 Suwa (10.1016/j.phymed.2021.153516_bib0019) 2003; 95 Rodgers (10.1016/j.phymed.2021.153516_bib0016) 2005; 434 Wang (10.1016/j.phymed.2021.153516_bib0024) 2012; 50 Liu (10.1016/j.phymed.2021.153516_bib0013) 2009; 284 Yuan (10.1016/j.phymed.2021.153516_bib0027) 2014; 15 Kang (10.1016/j.phymed.2021.153516_bib0008) 2012; 1271 Menghini (10.1016/j.phymed.2021.153516_bib0015) 2009; 120 Li (10.1016/j.phymed.2021.153516_bib0012) 2010; 45 Liu (10.1016/j.phymed.2021.153516_bib0014) 2018; 147 Wan (10.1016/j.phymed.2021.153516_bib0022) 2016; 94 Go (10.1016/j.phymed.2021.153516_bib0003) 2013; 127 Kann (10.1016/j.phymed.2021.153516_bib0009) 2007; 292 |
| References_xml | – volume: 120 start-page: 1524 year: 2009 end-page: 1532 ident: bib0015 article-title: MicroRNA 217 modulates endothelial cell senescence via silent information regulator 1 publication-title: Circulation contributor: fullname: Federici – volume: 50 start-page: 301 year: 2000 end-page: 307 ident: bib0011 article-title: Oxidation of methionine in proteins: roles in antioxidant defense and cellular regulation publication-title: IUBMB Life contributor: fullname: Stadtman – volume: 94 start-page: 919 year: 2016 end-page: 928 ident: bib0022 article-title: Chikusetsu saponin V attenuates H2O2-induced oxidative stress in human neuroblastoma SH-SY5Y cells through Sirt1/PGC-1alpha/Mn-SOD signaling pathways publication-title: Can. J. Physiol. Pharmacol. contributor: fullname: Wang – volume: 72 start-page: 193 year: 2006 end-page: 198 ident: bib0005 article-title: Suppression of Fas-mediated apoptosis of keratinocyte cells by chikusetsusaponins isolated from the roots of Panax japonicus publication-title: Planta Med. contributor: fullname: Yamada – year: 2019 ident: bib0023 article-title: Saponins of Panax japonicus attenuate neuronal apoptosis through oxidative stress-related pathways and autophagy in natural aging rats publication-title: Curr. Pharm. Biotechnol. contributor: fullname: Wang – volume: 66 start-page: 1641 year: 2014 end-page: 1651 ident: bib0025 article-title: Protective effect of saponins extract from Panax japonicus on myocardial infarction: involvement of NF-kappaB, Sirt1 and mitogen-activated protein kinase signalling pathways and inhibition of inflammation publication-title: J. Pharm. Pharmacol. contributor: fullname: Yuan – volume: 147 start-page: 803 year: 2018 end-page: 815 ident: bib0014 article-title: Z-Guggulsterone attenuates astrocytes-mediated neuroinflammation after ischemia by inhibiting toll-like receptor 4 pathway publication-title: J. Neurochem. contributor: fullname: Li – volume: 127 start-page: e6 year: 2013 end-page: e245 ident: bib0003 article-title: Heart disease and stroke statistics–2013 update: a report from the American Heart Association publication-title: Circulation contributor: fullname: Turner – volume: 284 start-page: 36109 year: 2009 end-page: 36117 ident: bib0013 article-title: Reversible cyclosporin A-sensitive mitochondrial depolarization occurs within minutes of stroke onset in mouse somatosensory cortex in vivo: a two-photon imaging study publication-title: J. Biol. Chem. contributor: fullname: Murphy – volume: 54 start-page: 7251 year: 2017 end-page: 7261 ident: bib0026 article-title: Downregulation of NAD-dependent deacetylase SIRT2 protects mouse brain against ischemic stroke publication-title: Mol. Neurobiol. contributor: fullname: Chen – volume: 4 start-page: 84 year: 2018 end-page: 94 ident: bib0017 article-title: Mitochondrial targeting as a novel therapy for stroke publication-title: Brain Circ. contributor: fullname: Napoli – volume: 50 start-page: 331 year: 2012 end-page: 336 ident: bib0024 article-title: Optimization of polysaccharides from Panax japonicus C.A. Meyer by RSM and its anti-oxidant activity publication-title: Int. J. Biol. Macromol. contributor: fullname: Ma – volume: 55 start-page: 234 year: 2006 end-page: 243 ident: bib0006 article-title: Mitochondrial membrane potential and ischemic neuronal death publication-title: Neurosci. Res. contributor: fullname: Iijima – volume: 73 start-page: 487 year: 2017 end-page: 494 ident: bib0021 article-title: Multi-regulatory network of ROS: the interconnection of ROS, PGC-1 alpha, and AMPK-SIRT1 during exercise publication-title: J. Physiol. Biochem. contributor: fullname: de Souza – volume: 104 start-page: 12017 year: 2007 end-page: 12022 ident: bib0007 article-title: AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha publication-title: Proc. Natl. Acad. Sci. U. S. A. contributor: fullname: Spiegelman – volume: 39 start-page: 1469 year: 2019 end-page: 1485 ident: bib0001 article-title: Continuous non-invasive optical monitoring of cerebral blood flow and oxidative metabolism after acute brain injury publication-title: J. Cereb. Blood Flow Metab. contributor: fullname: Andrew Kofke – volume: 19 start-page: 1466 year: 2005 end-page: 1473 ident: bib0020 article-title: Activation of nuclear receptor coactivator PGC-1alpha by arginine methylation publication-title: Genes Dev. contributor: fullname: Stallcup – volume: 292 start-page: C641 year: 2007 end-page: C657 ident: bib0009 article-title: Mitochondria and neuronal activity publication-title: Am. J. Physiol. Cell Physiol. contributor: fullname: Kovacs – volume: 434 start-page: 113 year: 2005 end-page: 118 ident: bib0016 article-title: Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1 publication-title: Nature contributor: fullname: Puigserver – volume: 47 start-page: 9 year: 2013 end-page: 23 ident: bib0018 article-title: Molecular mechanisms of ischemia-reperfusion injury in brain: pivotal role of the mitochondrial membrane potential in reactive oxygen species generation publication-title: Mol. Neurobiol. contributor: fullname: Huttemann – volume: 12 start-page: 7199 year: 2011 end-page: 7215 ident: bib0002 article-title: Roles of oxidative stress, apoptosis, PGC-1alpha and mitochondrial biogenesis in cerebral ischemia publication-title: Int. J. Mol. Sci. contributor: fullname: Chuang – volume: 15 start-page: 13209 year: 2014 end-page: 13222 ident: bib0027 article-title: Chikusetsu saponin V attenuates MPP+-induced neurotoxicity in SH-SY5Y cells via regulation of Sirt1/Mn-SOD and GRP78/caspase-12 pathways publication-title: Int. J. Mol. Sci. contributor: fullname: Wang – volume: 1271 start-page: 110 year: 2012 end-page: 117 ident: bib0008 article-title: Role of PGC-1alpha signaling in skeletal muscle health and disease publication-title: Ann. N. Y. Acad. Sci. contributor: fullname: Li Ji – volume: 95 start-page: 960 year: 2003 end-page: 968 ident: bib0019 article-title: Effects of chronic AICAR treatment on fiber composition, enzyme activity, UCP3, and PGC-1 in rat muscles publication-title: J. Appl. Physiol. contributor: fullname: Kumagai – volume: 45 start-page: 320 year: 2010 end-page: 331 ident: bib0012 article-title: Saponins from Panax japonicus protect against alcohol-induced hepatic injury in mice by up-regulating the expression of GPX3, SOD1 and SOD3 publication-title: Alcohol contributor: fullname: Chen – volume: 127 start-page: 1109 year: 2006 end-page: 1122 ident: bib0010 article-title: Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha publication-title: Cell contributor: fullname: Auwerx – volume: 140 start-page: 73 year: 2012 end-page: 82 ident: bib0004 article-title: Cardioprotective effects of saponins from Panax japonicus on acute myocardial ischemia against oxidative stress-triggered damage and cardiac cell death in rats publication-title: J. Ethnopharmacol. contributor: fullname: Yuan – volume: 15 start-page: 13209 year: 2014 ident: 10.1016/j.phymed.2021.153516_bib0027 article-title: Chikusetsu saponin V attenuates MPP+-induced neurotoxicity in SH-SY5Y cells via regulation of Sirt1/Mn-SOD and GRP78/caspase-12 pathways publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms150813209 contributor: fullname: Yuan – volume: 434 start-page: 113 year: 2005 ident: 10.1016/j.phymed.2021.153516_bib0016 article-title: Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1 publication-title: Nature doi: 10.1038/nature03354 contributor: fullname: Rodgers – volume: 95 start-page: 960 year: 2003 ident: 10.1016/j.phymed.2021.153516_bib0019 article-title: Effects of chronic AICAR treatment on fiber composition, enzyme activity, UCP3, and PGC-1 in rat muscles publication-title: J. Appl. Physiol. doi: 10.1152/japplphysiol.00349.2003 contributor: fullname: Suwa – year: 2019 ident: 10.1016/j.phymed.2021.153516_bib0023 article-title: Saponins of Panax japonicus attenuate neuronal apoptosis through oxidative stress-related pathways and autophagy in natural aging rats publication-title: Curr. Pharm. Biotechnol. contributor: fullname: Wan – volume: 50 start-page: 331 year: 2012 ident: 10.1016/j.phymed.2021.153516_bib0024 article-title: Optimization of polysaccharides from Panax japonicus C.A. Meyer by RSM and its anti-oxidant activity publication-title: Int. J. Biol. Macromol. doi: 10.1016/j.ijbiomac.2011.12.023 contributor: fullname: Wang – volume: 292 start-page: C641 year: 2007 ident: 10.1016/j.phymed.2021.153516_bib0009 article-title: Mitochondria and neuronal activity publication-title: Am. J. Physiol. Cell Physiol. doi: 10.1152/ajpcell.00222.2006 contributor: fullname: Kann – volume: 66 start-page: 1641 year: 2014 ident: 10.1016/j.phymed.2021.153516_bib0025 article-title: Protective effect of saponins extract from Panax japonicus on myocardial infarction: involvement of NF-kappaB, Sirt1 and mitogen-activated protein kinase signalling pathways and inhibition of inflammation publication-title: J. Pharm. Pharmacol. doi: 10.1111/jphp.12291 contributor: fullname: Wei – volume: 45 start-page: 320 year: 2010 ident: 10.1016/j.phymed.2021.153516_bib0012 article-title: Saponins from Panax japonicus protect against alcohol-induced hepatic injury in mice by up-regulating the expression of GPX3, SOD1 and SOD3 publication-title: Alcohol doi: 10.1093/alcalc/agq034 contributor: fullname: Li – volume: 120 start-page: 1524 year: 2009 ident: 10.1016/j.phymed.2021.153516_bib0015 article-title: MicroRNA 217 modulates endothelial cell senescence via silent information regulator 1 publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.109.864629 contributor: fullname: Menghini – volume: 47 start-page: 9 year: 2013 ident: 10.1016/j.phymed.2021.153516_bib0018 article-title: Molecular mechanisms of ischemia-reperfusion injury in brain: pivotal role of the mitochondrial membrane potential in reactive oxygen species generation publication-title: Mol. Neurobiol. doi: 10.1007/s12035-012-8344-z contributor: fullname: Sanderson – volume: 19 start-page: 1466 year: 2005 ident: 10.1016/j.phymed.2021.153516_bib0020 article-title: Activation of nuclear receptor coactivator PGC-1alpha by arginine methylation publication-title: Genes Dev. doi: 10.1101/gad.1295005 contributor: fullname: Teyssier – volume: 127 start-page: 1109 year: 2006 ident: 10.1016/j.phymed.2021.153516_bib0010 article-title: Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha publication-title: Cell doi: 10.1016/j.cell.2006.11.013 contributor: fullname: Lagouge – volume: 50 start-page: 301 year: 2000 ident: 10.1016/j.phymed.2021.153516_bib0011 article-title: Oxidation of methionine in proteins: roles in antioxidant defense and cellular regulation publication-title: IUBMB Life doi: 10.1080/15216540051081056 contributor: fullname: Levine – volume: 55 start-page: 234 year: 2006 ident: 10.1016/j.phymed.2021.153516_bib0006 article-title: Mitochondrial membrane potential and ischemic neuronal death publication-title: Neurosci. Res. doi: 10.1016/j.neures.2006.04.005 contributor: fullname: Iijima – volume: 147 start-page: 803 year: 2018 ident: 10.1016/j.phymed.2021.153516_bib0014 article-title: Z-Guggulsterone attenuates astrocytes-mediated neuroinflammation after ischemia by inhibiting toll-like receptor 4 pathway publication-title: J. Neurochem. doi: 10.1111/jnc.14583 contributor: fullname: Liu – volume: 94 start-page: 919 year: 2016 ident: 10.1016/j.phymed.2021.153516_bib0022 article-title: Chikusetsu saponin V attenuates H2O2-induced oxidative stress in human neuroblastoma SH-SY5Y cells through Sirt1/PGC-1alpha/Mn-SOD signaling pathways publication-title: Can. J. Physiol. Pharmacol. doi: 10.1139/cjpp-2015-0262 contributor: fullname: Wan – volume: 4 start-page: 84 year: 2018 ident: 10.1016/j.phymed.2021.153516_bib0017 article-title: Mitochondrial targeting as a novel therapy for stroke publication-title: Brain Circ. doi: 10.4103/bc.bc_14_18 contributor: fullname: Russo – volume: 39 start-page: 1469 year: 2019 ident: 10.1016/j.phymed.2021.153516_bib0001 article-title: Continuous non-invasive optical monitoring of cerebral blood flow and oxidative metabolism after acute brain injury publication-title: J. Cereb. Blood Flow Metab. doi: 10.1177/0271678X19846657 contributor: fullname: Baker – volume: 140 start-page: 73 year: 2012 ident: 10.1016/j.phymed.2021.153516_bib0004 article-title: Cardioprotective effects of saponins from Panax japonicus on acute myocardial ischemia against oxidative stress-triggered damage and cardiac cell death in rats publication-title: J. Ethnopharmacol. doi: 10.1016/j.jep.2011.12.024 contributor: fullname: He – volume: 72 start-page: 193 year: 2006 ident: 10.1016/j.phymed.2021.153516_bib0005 article-title: Suppression of Fas-mediated apoptosis of keratinocyte cells by chikusetsusaponins isolated from the roots of Panax japonicus publication-title: Planta Med. doi: 10.1055/s-2005-916176 contributor: fullname: Hosono-Nishiyama – volume: 284 start-page: 36109 year: 2009 ident: 10.1016/j.phymed.2021.153516_bib0013 article-title: Reversible cyclosporin A-sensitive mitochondrial depolarization occurs within minutes of stroke onset in mouse somatosensory cortex in vivo: a two-photon imaging study publication-title: J. Biol. Chem. doi: 10.1074/jbc.M109.055301 contributor: fullname: Liu – volume: 54 start-page: 7251 year: 2017 ident: 10.1016/j.phymed.2021.153516_bib0026 article-title: Downregulation of NAD-dependent deacetylase SIRT2 protects mouse brain against ischemic stroke publication-title: Mol. Neurobiol. doi: 10.1007/s12035-016-0173-z contributor: fullname: Xie – volume: 1271 start-page: 110 year: 2012 ident: 10.1016/j.phymed.2021.153516_bib0008 article-title: Role of PGC-1alpha signaling in skeletal muscle health and disease publication-title: Ann. N. Y. Acad. Sci. doi: 10.1111/j.1749-6632.2012.06738.x contributor: fullname: Kang – volume: 73 start-page: 487 year: 2017 ident: 10.1016/j.phymed.2021.153516_bib0021 article-title: Multi-regulatory network of ROS: the interconnection of ROS, PGC-1 alpha, and AMPK-SIRT1 during exercise publication-title: J. Physiol. Biochem. doi: 10.1007/s13105-017-0576-y contributor: fullname: Thirupathi – volume: 12 start-page: 7199 year: 2011 ident: 10.1016/j.phymed.2021.153516_bib0002 article-title: Roles of oxidative stress, apoptosis, PGC-1alpha and mitochondrial biogenesis in cerebral ischemia publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms12107199 contributor: fullname: Chen – volume: 104 start-page: 12017 year: 2007 ident: 10.1016/j.phymed.2021.153516_bib0007 article-title: AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.0705070104 contributor: fullname: Jager – volume: 127 start-page: e6 year: 2013 ident: 10.1016/j.phymed.2021.153516_bib0003 article-title: Heart disease and stroke statistics–2013 update: a report from the American Heart Association publication-title: Circulation contributor: fullname: Go |
| SSID | ssj0014970 |
| Score | 2.4206479 |
| Snippet | Oxidative stress and frequently unwanted alterations in mitochondrial structure and function are key aspects of the pathological cascade in transient focal... BACKGROUNDOxidative stress and frequently unwanted alterations in mitochondrial structure and function are key aspects of the pathological cascade in transient... |
| SourceID | proquest crossref pubmed elsevier |
| SourceType | Aggregation Database Index Database Publisher |
| StartPage | 153516 |
| SubjectTerms | Animals Antioxidants - metabolism Brain Ischemia - drug therapy Brain Ischemia - physiopathology Chikusetsu saponin V Infarction, Middle Cerebral Artery Male Mice Mitochondria - drug effects Mitochondria - metabolism Mitochondria - ultrastructure Mitochondrial damages Neurons - drug effects Neurons - pathology Neuroprotection Neuroprotective Agents - pharmacology Oxidative stress Oxidative Stress - drug effects Panax - chemistry PGC-1α Rats Rats, Sprague-Dawley Reactive Oxygen Species - metabolism Reperfusion Injury - prevention & control Saponins - chemistry Saponins - pharmacology Transient focal cerebral ischemia/reperfusion |
| Title | Neuroprotection of Chikusetsu saponin V on transient focal cerebral ischemia/reperfusion and the underlying mechanism |
| URI | https://dx.doi.org/10.1016/j.phymed.2021.153516 https://www.ncbi.nlm.nih.gov/pubmed/33639592 https://search.proquest.com/docview/2494289562 |
| Volume | 84 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwEB6VrYS4IFpeC7QyEuqp7iaxs3GO1arVwoqqghZ6s-LYVgPd7GqTHHrhtzOTR6tKICROeSuJx5lvvni-McCHPBCpyk3IbeQdl9Kl3OTKcJ8hjQuMi5RtE2TPpvNL-ekqvtqC2aCFobTK3vd3Pr311v2eSd-ak3VRTL4iMUHPGpIIhSbHQwq0jXAUqRFsH39czM_uBhNk2s4ZR-dzumBQ0LVpXvgyCDtIFKPwCL_-mCY-_zNC_S0CbZHo9Bk87UNIdtw95Q5suXIXHn_uB8l34eC8K0d9e8gu7tVV1SE7YOf3hapvn0PTVuboKzWgfdjKs9l18bOpXF01rMrW9K-WfWN4qCZMI-0k84R-LHcbGnK-YQXSY7csqNDU2m18Q3_fWFZahpElI4Xa5oaUVGzpSGNcVMsXcHl6cjGb834aBp4jutU8CVKMKoMsMNLkEiO60GbeWiWmDleR_oQ-NkrkYZREystUicwiLvowJ1GvkeIljMpV6V4DS6foX-M09kTDEpsYqeKpyLwXcWK9D8bAh6bX667ahh7S0H7ozlSaTKU7U40hGeyjH_QajYDwjyvfD-bU-EHRKElWulVTaeSjSMmQNkZjeNXZ-e5ZhMCALk6jN_9937fwhLa63J93MKo3jdvDsKY2-_Do6Fe433deWi6-fF_8BhxC-h0 |
| link.rule.ids | 315,783,787,4509,24128,27936,27937,45597,45691 |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1La9wwEB5CAm0vpUlf20eqQskp6tqWvLaOYUnYNMkS6KbkJixLIm6z3mVtH_LvO-NHQqGh0JuxLGxrpJn5NPONAL7kgVBpbkJuI--4lE5xk6eG-wxhXGBclNo2QXY-mV3Jb9fx9RZMBy4MpVX2ur_T6a227u-M-9Ecr4ti_B2BCWrWkEgodDgeQqAd9AYUrs6do9Oz2fw-mCBVe2YcPc-pw8Cga9O88GfQ7CBQjMKvuPpjOvj87xbqMQ-0tUQnL-B570Kyo-4rd2HLlXvw5KIPku_BwWVXjvrukC0e2FXVITtglw-Fqu9eQtNW5ugrNaB82Mqz6U3xq6lcXTWsyta0V8t-MGyqyaYRd5J5sn4sdxsKOd-yAuGxWxZUaGrtNr6h3TeWlZahZ8mIoba5JSYVWzriGBfV8hVcnRwvpjPeH8PAc7RuNU8ChV5lkAVGmlyiRxfazFubionDS4Q_oY9NKvIwSqLUS5WKzKJd9GFOpF4jxWvYLlelewtMTVC_xir2BMMSmxiZxhOReS_ixHofjIAPQ6_XXbUNPaSh_dSdqDSJSneiGkEyyEf_MWs0GoR_9Pw8iFPjgqIoSVa6VVNpxKMIyRA2RiN408n5_luEQIcuVtG7_37vJ3g6W1yc6_PT-dl7eEYtXR7QB9iuN437iC5Obfb7KfwbVVn6bg |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Neuroprotection+of+Chikusetsu+saponin+V+on+transient+focal+cerebral+ischemia%2Freperfusion+and+the+underlying+mechanism&rft.jtitle=Phytomedicine+%28Stuttgart%29&rft.au=Zhang%2C+Tiejun&rft.au=Li%2C+Zhengjun&rft.au=Qin%2C+Zhou&rft.au=Cao%2C+Yi&rft.date=2021-04-01&rft.eissn=1618-095X&rft.volume=84&rft.spage=153516&rft_id=info:doi/10.1016%2Fj.phymed.2021.153516&rft_id=info%3Apmid%2F33639592&rft.externalDocID=33639592 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0944-7113&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0944-7113&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0944-7113&client=summon |