Coordination between NADPH oxidase and vascular peroxidase 1 promotes dysfunctions of endothelial progenitor cells in hypoxia-induced pulmonary hypertensive rats

• Published in: European journal of pharmacology Vol. 857; p. 172459
• Main Authors: Wang, E-Li, Jia, Miao-Miao, Luo, Fang-Mei, Li, Tao, Peng, Jing-Jie, Luo, Xiu-Ju, Song, Feng-Lin, Yang, Jin-Fu, Peng, Jun, Liu, Bin
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.08.2019
• Subjects: Animals; Apoptosis; Cell Hypoxia; Dysfunction; Endothelial progenitor cells; Endothelial Progenitor Cells - pathology; Gene Knockdown Techniques; Hemeproteins - deficiency; Hemeproteins - genetics; Hemeproteins - metabolism; Hypertension, Pulmonary - enzymology; Hypertension, Pulmonary - genetics; Hypertension, Pulmonary - pathology; Hypoxia; Male; NADPH oxidase; NADPH Oxidase 2 - deficiency; NADPH Oxidase 2 - genetics; NADPH Oxidase 2 - metabolism; NADPH Oxidase 4 - deficiency; NADPH Oxidase 4 - genetics; NADPH Oxidase 4 - metabolism; Peroxidases - deficiency; Peroxidases - genetics; Peroxidases - metabolism; Phenotype; Pulmonary hypertension; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species - metabolism; RNA, Small Interfering - genetics; Vascular peroxidase 1; Hypoxia; Vascular peroxidase 1; Dysfunction; NADPH oxidase; Pulmonary hypertension; Endothelial progenitor cells

Previous studies have demonstrated that NADPH oxidase (NOX)/vascular peroxidase (VPO1) pathway – mediated oxidative stress plays an important role in the pathogenesis of multiple cardiovascular diseases. This study aims to evaluate the correlation between NOX/VPO1 pathway and endothelial progenitor...