Mannose Binding Lectin and Pentraxin 3 in Patients with Diabetic Retinopathy
Mannose binding lectin (MBL) is a protein of the complement system and pentraxin-3 (PTX3) is an acute phase protein both with an important role in inflammatory diseases, such as diabetic retinopathy (DR). To evaluate whether plasma MBL and PTX3 levels are associated with the development of DR and if...
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Published in | Archives of medical research Vol. 49; no. 2; pp. 123 - 129 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
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Elsevier Inc
01.02.2018
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Abstract | Mannose binding lectin (MBL) is a protein of the complement system and pentraxin-3 (PTX3) is an acute phase protein both with an important role in inflammatory diseases, such as diabetic retinopathy (DR).
To evaluate whether plasma MBL and PTX3 levels are associated with the development of DR and if patients with and without DR can be distinguished.
The patients were divided into three groups: diabetic without DR; with mild/moderate DR, and with severe/proliferative DR. PTX3 and MBL levels were measured with enzyme-linked immunosorbent assay kits.
A total of 74 patients were included. A significant association was observed between high levels of MBL and severe DR; 47% of patients with severe/proliferative DR had high levels of MBL, whereas 12% of the patients with diabetes but no DR had high levels of MBL (p = 0.008; odds ratio [OR]: 6.06; 95% confidence interval [CI]: 1.4–25.0). High levels of MBL were more frequent in patients with severe/proliferative disease (47%) when compared to those with mild/moderate DR (20%), p = 0.04 (OR: 3.46; 95% CI: 1.0–11.8). PTX3 levels were similar among the groups and were not related to the development or severity of DR.
We found a significant association between high plasma MBL levels and DR development as well as with severe/proliferative DR. We observed no relationship between plasma PTX3 levels and the development or severity of DR. |
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AbstractList | Mannose binding lectin (MBL) is a protein of the complement system and pentraxin-3 (PTX3) is an acute phase protein both with an important role in inflammatory diseases, such as diabetic retinopathy (DR).
To evaluate whether plasma MBL and PTX3 levels are associated with the development of DR and if patients with and without DR can be distinguished.
The patients were divided into three groups: diabetic without DR; with mild/moderate DR, and with severe/proliferative DR. PTX3 and MBL levels were measured with enzyme-linked immunosorbent assay kits.
A total of 74 patients were included. A significant association was observed between high levels of MBL and severe DR; 47% of patients with severe/proliferative DR had high levels of MBL, whereas 12% of the patients with diabetes but no DR had high levels of MBL (p = 0.008; odds ratio [OR]: 6.06; 95% confidence interval [CI]: 1.4-25.0). High levels of MBL were more frequent in patients with severe/proliferative disease (47%) when compared to those with mild/moderate DR (20%), p = 0.04 (OR: 3.46; 95% CI: 1.0-11.8). PTX3 levels were similar among the groups and were not related to the development or severity of DR.
We found a significant association between high plasma MBL levels and DR development as well as with severe/proliferative DR. We observed no relationship between plasma PTX3 levels and the development or severity of DR. BACKGROUNDMannose binding lectin (MBL) is a protein of the complement system and pentraxin-3 (PTX3) is an acute phase protein both with an important role in inflammatory diseases, such as diabetic retinopathy (DR). AIM OF THE STUDYTo evaluate whether plasma MBL and PTX3 levels are associated with the development of DR and if patients with and without DR can be distinguished. METHODSThe patients were divided into three groups: diabetic without DR; with mild/moderate DR, and with severe/proliferative DR. PTX3 and MBL levels were measured with enzyme-linked immunosorbent assay kits. RESULTSA total of 74 patients were included. A significant association was observed between high levels of MBL and severe DR; 47% of patients with severe/proliferative DR had high levels of MBL, whereas 12% of the patients with diabetes but no DR had high levels of MBL (p = 0.008; odds ratio [OR]: 6.06; 95% confidence interval [CI]: 1.4-25.0). High levels of MBL were more frequent in patients with severe/proliferative disease (47%) when compared to those with mild/moderate DR (20%), p = 0.04 (OR: 3.46; 95% CI: 1.0-11.8). PTX3 levels were similar among the groups and were not related to the development or severity of DR. CONCLUSIONWe found a significant association between high plasma MBL levels and DR development as well as with severe/proliferative DR. We observed no relationship between plasma PTX3 levels and the development or severity of DR. |
Author | Portugal, Vanessa Hokazono, Kenzo Messias-Reason, Iara Belizário, Fernando Sakata Nisihara, Renato |
Author_xml | – sequence: 1 givenname: Kenzo surname: Hokazono fullname: Hokazono, Kenzo organization: Department of Ophthalmology, Federal University of Paraná, Paraná, Brazil – sequence: 2 givenname: Fernando Sakata surname: Belizário fullname: Belizário, Fernando Sakata organization: Department of Medicine, Positivo University, Curitiba, Paraná, Brazil – sequence: 3 givenname: Vanessa surname: Portugal fullname: Portugal, Vanessa organization: Department of Medicine, Positivo University, Curitiba, Paraná, Brazil – sequence: 4 givenname: Iara surname: Messias-Reason fullname: Messias-Reason, Iara organization: Laboratory of Molecular Immunopathology, Hospital de Clínicas, Federal University of Paraná, Curitiba, Paraná, Brazil – sequence: 5 givenname: Renato surname: Nisihara fullname: Nisihara, Renato email: renatonisihara@up.edu.br organization: Department of Medicine, Positivo University, Curitiba, Paraná, Brazil |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29961608$$D View this record in MEDLINE/PubMed |
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Keywords | Biomarkers Diabetic retinopathy Pentraxin 3 MBL |
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Snippet | Mannose binding lectin (MBL) is a protein of the complement system and pentraxin-3 (PTX3) is an acute phase protein both with an important role in inflammatory... BACKGROUNDMannose binding lectin (MBL) is a protein of the complement system and pentraxin-3 (PTX3) is an acute phase protein both with an important role in... |
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Title | Mannose Binding Lectin and Pentraxin 3 in Patients with Diabetic Retinopathy |
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