TNF receptors are associated with tau pathology and conversion to Alzheimer’s dementia in subjects with mild cognitive impairment

• Published in: Neuroscience letters Vol. 738; p. 135392
• Main Authors: Zhao, Aonan, Li, Yuanyuan, Deng, Yulei
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.11.2020
• Subjects: Aged; Aged, 80 and over; Alzheimer Disease - complications; Alzheimer Disease - metabolism; Alzheimer Disease - pathology; Alzheimer’s disease; Biomarkers - cerebrospinal fluid; Cognitive Dysfunction - complications; Cognitive Dysfunction - diagnosis; Cognitive Dysfunction - metabolism; Cross-Sectional Studies; Disease Progression; Female; Humans; Male; MCI-to-AD conversion; Middle Aged; Mild cognitive impairment; Peptide Fragments - cerebrospinal fluid; Receptors, Tumor Necrosis Factor - metabolism; tau Proteins - metabolism; Tumor necrosis factor; Tumor necrosis factor receptor; Alzheimer’s disease; Tumor necrosis factor; Mild cognitive impairment; MCI-to-AD conversion; Tumor necrosis factor receptor

•higher CSF levels of TNF-α related inflammatory proteins in the MCI and AD patients with positive tau pathology.•TNF receptors were associated with t-tau and p-tau, other than Aβ1-42, in HC, MCI and AD subjects.•TNF receptors are potential early predictors for the MCI-to-AD conversion. Tumor necros...