Human mesenchymal stem cells improve the neurodegeneration of femoral nerve in a diabetic foot ulceration rats

• Published in: Neuroscience letters Vol. 597; pp. 84 - 89
• Main Authors: Xia, Nan, Xu, Jin-Mei, Zhao, Nan, Zhao, Qing-Song, Li, Ming, Cheng, Zhi-Feng
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 15.06.2015
• Subjects: Animals; Diabetes Mellitus, Experimental - pathology; Diabetes Mellitus, Experimental - physiopathology; Diabetes Mellitus, Experimental - therapy; Diabetic foot; Diabetic Foot - pathology; Diabetic Foot - physiopathology; Diabetic Foot - therapy; Electroneurogram; Femoral Nerve - metabolism; Femoral Nerve - pathology; Femoral Nerve - physiopathology; Human mesenchymal stem cells from umbilical cord matrix; Humans; Male; Mesenchymal Stem Cell Transplantation; Muscle, Skeletal - blood supply; Muscle, Skeletal - innervation; Neovascularization, Physiologic; Nerve Degeneration - pathology; Nerve Degeneration - physiopathology; Nerve Degeneration - therapy; Nerve Growth Factor - blood; Neural Conduction; Neurofilament; Neurofilament Proteins - metabolism; Neurons - metabolism; NGF; Peripheral neuropathy; Rats, Sprague-Dawley; Neurofilament; Human mesenchymal stem cells from umbilical cord matrix; Peripheral neuropathy; NGF; Electroneurogram; Diabetic foot

•hMSCs-UC partially reverse the degeneration of FN via upregulation of NGF, NF-200 and angiogenesis.•hMSCs-UC reverse at least partially the damages in myelination of FN revealed by EM data.•The function of FN is improved after by hMSCs-UC revealed by compound action potential recording.•This findin...