Synthesis and evaluation of pyrrolobenzodiazepine dimer antibody-drug conjugates with dual β-glucuronide and dipeptide triggers - Gregson, Stephen J.; Barrett, Allison M.; Patel, Neki V.; Kang, Gyoung-Dong; Schiavone, Davide; Sult, Erin; Barry, Conor S.; Vijayakrishnan, Balakumar; Adams, Lauren R.; Masterson, Luke A.; D'Hooge, Francois; Snaith, Mike; et al. (European journal of medicinal chemistry, 2019)
Keywords: Antibody-drug conjugate; Chemistry, Medicinal; Life Sciences & Biomedicine; Pharmacology & Pharmacy; Prodrug; Pyrrolobenzodiazepine; Science & Technology; Serum stability; β-Glucuronidase; β-Glucuronidase; Serum stability; Prodrug; Pyrrolobenzodiazepine; Antibody-drug conjugate; DESIGN; EFFICACY; CANCER; POTENT; CROSS-LINKING AGENT; IN-VITRO EVALUATION; beta-Glucuronidase; SELECTIVE THERAPY; SPECTRUM ANTITUMOR-ACTIVITY; SJG-136 NSC-694501