Three approaches to improving performance of liquid chromatography using contour maps with pressure, time, and number of theoretical plates

• Published in: Journal of Chromatography A Vol. 1637; p. 461778
• Main Authors: Ito, Masahito, Shimizu, Katsutoshi, Nakatani, Kiyoharu
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 25.01.2021
• Subjects: Chromatography, Liquid - methods; Coefficients of pressure-application; Hold-up time; Kinetic performance limit; Models, Theoretical; Number of theoretical plates; Optimal velocity; Pressure; Pressure drop; Time Factors; Number of theoretical plates; Kinetic performance limit; Hold-up time; Optimal velocity; Pressure drop; Coefficients of pressure-application

•Contour map with three axes, of pressure, time, and number of theoretical plates•Flow rate and column length are varied to improve speed or separation performance•A method to improve separation by increasing the pressure while maintaining time•An alternative approach for increasing speed by pressur...