METTL3-driven m6A modification of lncRNA FAM230B suppresses ferroptosis by modulating miR-27a-5p/BTF3 axis in gastric cancer

• Published in: Biochimica et biophysica acta. General subjects Vol. 1868; no. 11; p. 130714
• Main Authors: Cui, Yejia, Pu, Meicen, Gong, Yanting, Li, Runchao, Wang, Xiaokang, Ye, Jinjun, Huang, Haohai, Liao, Dan, Yang, Yufeng, Yin, Aiping, Li, Jiale, Deng, Yuling, Tian, Zhen, Pu, Rong
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.11.2024
• Subjects: Adenosine - analogs & derivatives; Adenosine - genetics; Adenosine - metabolism; BTF3; Cell Line, Tumor; FAM230B; Ferroptosis; Ferroptosis - genetics; Gastric cancer; Gene Expression Regulation, Neoplastic; Humans; Methyltransferases - genetics; Methyltransferases - metabolism; MicroRNAs - genetics; MicroRNAs - metabolism; miR-27a-5p; N6-methyladenosine; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; Stomach Neoplasms - genetics; Stomach Neoplasms - metabolism; Stomach Neoplasms - pathology; BTF3; Ferroptosis; N6-methyladenosine; Gastric cancer; FAM230B; miR-27a-5p

Our previous research revealed the apoptosis-inhibiting effect of lncRNA FAM230B in gastric cancer (GC). While its role on ferroptosis of GC remain unexplored. In this study, the m6A level and RNA stability regulation of METTL3 on FAM230B was detected by m6A quantification, stability assays, MeRIP,...