Immunosuppressive effects of morphine on macrophage polarization and function

• Published in: European journal of pharmacology Vol. 975; p. 176637
• Main Authors: Malik, Jonaid Ahmad, Affan Khan, Mohammad, Lamba, Taruna, Adeel Zafar, Mohammad, Nanda, Sidhanta, Owais, Mohammad, Agrewala, Javed N.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.07.2024
• Subjects: Animals; Antigen uptake; Cell Differentiation - drug effects; Cell Polarity - drug effects; Immunosuppression; Immunosuppressive Agents - pharmacology; Interleukin-1beta - metabolism; M1 macrophage; M2 macrophage; Macrophage Activation - drug effects; Macrophages - drug effects; Macrophages - immunology; Male; Mice; Mice, Inbred C57BL; Morphine; Morphine - pharmacology; Nitric Oxide Synthase Type II - metabolism; Phagocytosis - drug effects; Antigen uptake; Morphine; M2 macrophage; Immunosuppression; M1 macrophage

Macrophages play a pivotal role in safeguarding against a broad spectrum of infections, from viral, bacterial, fungal to parasitic threats and contributing to the immune defense against cancer. While morphine's immunosuppressive effects on immune cells are extensively documented, a significant...