Regulation of the α-ketoglutarate dehydrogenasecomplex during hibernation in a small mammal, the Richardson's ground squirrel (Urocitellus richardsonii)

• Published in: Biochimica et biophysica acta. Proteins and proteomics Vol. 1868; no. 9; p. 140448
• Main Authors: Green, Stuart R., Storey, Kenneth B.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.09.2020
• Subjects: Citric acid cycle; Hibernation; Ketoglutarate dehydrogenase complex; Muscle; Post-translational modifications; Richardson's ground squirrel; Km; CAC; Richardson's ground squirrel; Vmax; PTM; DLST; Ketoglutarate dehydrogenase complex; Post-translational modifications; PEG; Hibernation; KA; α-KG; KGDC; OGDH; Citric acid cycle; Muscle; DLD

The citric acid cycle (CAC) is a central metabolic pathway that links carbohydrate, lipid, and amino acid metabolism in the mitochondria and, hence, is a crucial target for metabolic regulation. The α-ketoglutarate dehydrogenase complex (KGDC) is the rate-limiting step of the CAC, the three enzymes...