Analysis of POU5F1, c-Kit, PLAP, AP2γ and SALL4 in gonocytes of patients with cryptorchidism

• Published in: Acta histochemica Vol. 117; no. 8; pp. 752 - 761
• Main Authors: Vigueras-Villaseñor, Rosa María, Cortés-Trujillo, Lucero, Chávez-Saldaña, Margarita, Vázquez, Francisco García, Carrasco-Daza, Daniel, Cuevas-Alpuche, Osvaldo, Rojas-Castañeda, Julio César
• Format: Journal Article
• Language: English
• Published: Germany Elsevier GmbH 01.10.2015
• Subjects: Adolescent; AP2γ; Biomarkers - metabolism; c-Kit; Child; Child, Preschool; Cryptorchidism; Cryptorchidism - metabolism; Extracellular Matrix Proteins - metabolism; Gonocytes; Humans; Infant; Infant, Newborn; Intratubular germ cell neoplasia unclassified; Male; Octamer Transcription Factor-3 - metabolism; PLAP; POU5F1; Proto-Oncogene Proteins c-kit - metabolism; SALL4; Spermatozoa - metabolism; Testis - metabolism; Testis - pathology; Transcription Factor AP-2 - metabolism; Transcription Factors - metabolism; Gonocytes; c-Kit; SALL4; Intratubular germ cell neoplasia unclassified; Cryptorchidism; POU5F1; PLAP; AP2γ

Cryptorchidism is a risk factor for the development of testicular germ cell tumors (TGCTs). The most common type of TGCT in cryptorchidism is seminoma. The intratubular germ cell neoplasia unclassified (ITGCNU) is a histological pattern preceding the development of seminomas and non-seminomas. It wa...