Antioxidant and antitumor activity of trolox, trolox succinate, and α-tocopheryl succinate conjugates with nitroxides

• Published in: European journal of medicinal chemistry Vol. 122; pp. 127 - 137
• Main Authors: Zakharova, Ol’ga D., Frolova, Tat’yana S., Yushkova, Yuliya V., Chernyak, Elena I., Pokrovsky, Andrei G., Pokrovsky, Mikhail A., Morozov, Sergei V., Sinitsina, Ol’ga I., Grigor’ev, Igor A., Nevinsky, Georgy A.
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 21.10.2016
• Subjects: alpha-Tocopherol - chemistry; alpha-Tocopherol - pharmacology; Animals; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Antioxidants; Antioxidants - chemistry; Antioxidants - pharmacology; Antitumor activity; Cell Line, Tumor; Chromans - chemistry; Chromans - pharmacology; Cricetinae; Humans; Mice; Nitrogen Oxides - chemistry; Nitroxides; Succinic Acid - chemistry; Trolox; α-tocopheryl succinate; TroS; α-TOS; EPR; pNPP; TLC; HFI; α-TOH; t-BuO2H; Antioxidants; TroH; ONPG; Trolox; ROS; IC50; Antitumor activity; Nitroxides; α-tocopheryl succinate

A possible ability of twelve new derivatives of known antioxidants trolox (TroH), trolox succinate (TroS), α-tocopheryl succinate (α-TOS) containing nitroxyl radicals (1–12) to protect bacterial cells from spontaneous and peroxide-induced mutagenesis and their cytotoxicity against six different tumo...