STAT4 targets KISS1 to inhibit the oxidative damage, inflammation and neuronal apoptosis in experimental PD models by inactivating the MAPK pathway

• Published in: Neurochemistry international Vol. 175; p. 105683
• Main Authors: Zhang, XiaoLei, Wang, Yu, Lv, Jia
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.05.2024
• Subjects: Animals; Apoptosis; Cell Line, Tumor; Culture Media, Conditioned - pharmacology; Humans; Inflammation; Inflammation - chemically induced; Inflammation - metabolism; KISS1; Kisspeptins; Lipopolysaccharides - pharmacology; MAPK; Mice; Mice, Inbred C57BL; Neuroblastoma; Oxidative Stress; Parkinson Disease - metabolism; Parkinson's disease; Sincalide - adverse effects; Sincalide - metabolism; STAT4; STAT4 Transcription Factor - metabolism; KISS1; STAT4; Oxidative stress; Inflammation; Parkinson's disease; MAPK

Oxidative stress and neuroinflammation are proven to play critical roles in the pathogenesis of Parkinson's disease (PD). As reported, patients with PD have lower level of STAT4 compared with healthy subjects. However, the biological functions and mechanisms of STAT4 in PD pathogenesis remain u...