Preconditioning of mesenchymal stem cells with ghrelin exerts superior cardioprotection in aged heart through boosting mitochondrial function and autophagy flux - Sun, Liqiang; Zhang, Wenlong (European journal of pharmacology, 2021)
Keywords: Aged; Animals; Autophagy; Autophagy - drug effects; Beclin-1 - metabolism; Cardioprotection; Cardiotonic Agents - pharmacology; Cardiotonic Agents - therapeutic use; Chloroquine - pharmacology; Chloroquine - therapeutic use; Drug Synergism; Ghrelin; Ghrelin - pharmacology; Ghrelin - therapeutic use; Humans; L-Lactate Dehydrogenase - metabolism; Male; Membrane Potential, Mitochondrial - drug effects; Mesenchymal stem cell; Mesenchymal Stem Cell Transplantation - methods; Mesenchymal Stem Cells - drug effects; Mesenchymal Stem Cells - physiology; Microtubule-Associated Proteins - metabolism; Mitochondria; Mitochondria - drug effects; Mitochondria - metabolism; Myocardial Infarction - etiology; Myocardial Infarction - metabolism; Myocardial Infarction - pathology; Myocardial Infarction - therapy; Myocardial Reperfusion Injury - etiology; Myocardial Reperfusion Injury - metabolism; Myocardial Reperfusion Injury - pathology; Myocardial Reperfusion Injury - therapy; Nicotinamide Mononucleotide - pharmacology; Nicotinamide Mononucleotide - therapeutic use; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species - metabolism; Sequestosome-1 Protein - metabolism; Troponin C - blood; Mesenchymal stem cell; Mitochondria; Cardioprotection; Ghrelin; Autophagy