Tryptophan hydroxylase 2 gene is associated with cognition in late-onset depression in a Chinese Han population

• Published in: Neuroscience letters Vol. 600; pp. 98 - 103
• Main Authors: Wang, Xiaoquan, Wang, Zusen, Wu, Yanfeng, Hou, Zhenghua, Yuan, Yonggui, Hou, Gang
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 23.07.2015
• Subjects: Aged; Aged, 80 and over; Asian Continental Ancestry Group; Case-Control Studies; Cognition Disorders - complications; Cognition Disorders - genetics; Cognitive function; Depression - complications; Depression - genetics; Female; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Late-onset; Major depressive disorder; Male; Middle Aged; Polymorphism, Genetic; TPH2; Tryptophan Hydroxylase - genetics; TPH2; Cognitive function; Major depressive disorder; Late-onset

•There may be a major effect in TPH2 gene on cognition in LOD patients alone.•An interaction of TPH2 gene and depression may be affect the cognition in LOD.•Some domain of cognition may be affected by the severity of depression. Accumulating evidences suggest that Tryptophan hydroxylase 2 (TPH2) gen...