Striatal μ-opioid receptor availability predicts cold pressor pain threshold in healthy human subjects

• Published in: Neuroscience letters Vol. 521; no. 1; pp. 11 - 14
• Main Authors: Hagelberg, Nora, Aalto, Sargo, Tuominen, Lauri, Pesonen, Ullamari, Någren, Kjell, Hietala, Jarmo, Scheinin, Harry, Pertovaara, Antti, Martikainen, Ilkka K.
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 11.07.2012
• Subjects: [11C]carfentanil; Adult; Carbon Radioisotopes; Cold Temperature; Corpus Striatum - diagnostic imaging; Corpus Striatum - metabolism; Fentanyl - analogs & derivatives; Fentanyl - metabolism; Humans; Male; Pain; Pain - physiopathology; Pain Threshold; Positron emission tomography; Radiopharmaceuticals - metabolism; Receptors, Opioid, mu - agonists; Receptors, Opioid, mu - metabolism; Reference Values; Striatum; Touch; μ-Opioid receptor; ACC; CPP; [11C]carfentanil; FM; PFC; ROI; μ-Opioid receptor; MOR; Striatum; Pain; NAcc; BPND; Positron emission tomography; PET

► Imaging of [11C]carfentanil binding allows determining brain μ-opioid receptor availability. ► Striatal μ-opioid receptor availability predicted cold pressor pain threshold in healthy males. ► μ-Opioid receptor availability failed to correlate with cold pain tolerance or tactile threshold. ► Stria...