High-altitude exposure decreases bone mineral density and its relationship with gut microbiota: Results from the China multi-ethnic cohort (CMEC) study

• Published in: Environmental research Vol. 215; no. Pt 2; p. 114206
• Main Authors: Zuo, Haojiang, Zheng, Tianli, Wu, Kunpeng, Yang, Tingting, Wang, Lingyao, Nima, Qucuo, Bai, Hua, Dong, Ke, Fan, Ziwei, Huang, Shourui, Luo, Ruocheng, Wu, Jialong, Zhou, Junmin, Xu, Huan, Zhang, Yingcong, Feng, Shiyu, Zeng, Peibin, Xiao, Xiong, Guo, Bing, Wei, Yonglan, Pei, Xiaofang, Zhao, Xing
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.12.2022
• Subjects: Adult; Altitude; Bone Density; Bone mineral density (BMD); Butyric Acid - analysis; Butyric Acid - pharmacology; Fatty Acids, Volatile - analysis; Feces - chemistry; Gastrointestinal Microbiome; High-altitude exposure; Humans; Mediation analysis; Microbiota; Osteoporosis; RNA, Ribosomal, 16S - genetics; Short-chain fatty acids (SCFAs); Osteoporosis; Bone mineral density (BMD); Microbiota; Short-chain fatty acids (SCFAs); Mediation analysis; High-altitude exposure

Geographic altitude is a potent environmental factor for human microbiota and bone mineral density. However, little evidence exists in population-based studies with altitude diversity ranges across more than 3000 m. This study assessed the associations between a wide range of altitudes and bone mine...