In-bioreactor ultrasonic monitoring of 3D culture human engineered cartilage

• Published in: Sensors and actuators. B, Chemical Vol. 266; pp. 841 - 852
• Main Authors: Melchor, J., López-Ruiz, E., Soto, J., Jiménez, G., Antich, C., Perán, M., Baena, J.M., Marchal, J.A., Rus, G.
• Format: Journal Article
• Language: English
• Published: Lausanne Elsevier B.V 01.08.2018; Elsevier Science Ltd
• Subjects: Bioreactor; Bioreactors; Biosensors; Cartilage; Chondrocytes; Elastic damping; Evolution; Feasibility studies; Gene expression; Inverse problem; Inverse problems; Iterative methods; Mathematical models; Membrane reactors; Monitoring; Parameters; Polylactic acid; Qualitative analysis; Scaffolds; Signal analysis; Signal processing; Ultrasonic attenuation; Ultrasonic imaging; Ultrasounds; Wave attenuation; Ultrasounds; Bioreactor; Scaffolds; Chondrocytes; Inverse problem

[Display omitted] •Ultrasonic bioreator design to implement a non-invasive real-time monitoring of the neo-cartilage tissue formation process.•Numerical models combined with stochastic.•Inverse Problem of the ultrasound-tissue interaction to infer the ECM evolution.•Validate ultrasound data against...