Inflammatory and Apoptotic Regulatory Activity of Tanshinone IIA in Helicobacter pylori-Infected Cells

• Published in: The American journal of Chinese medicine (1979) Vol. 44; no. 6; p. 1187
• Main Authors: Chen, Guan-Yu, Shu, Yu-Chieh, Chuang, Duen-Yau, Wang, Yuan-Chuen
• Format: Journal Article
• Language: English
• Published: Singapore 01.01.2016
• Subjects: Animals; Apoptosis - drug effects; Apoptosis - genetics; bcl-2-Associated X Protein - genetics; bcl-2-Associated X Protein - metabolism; Caspase 9 - genetics; Caspase 9 - metabolism; Cell Line, Tumor; Diterpenes, Abietane - isolation & purification; Diterpenes, Abietane - pharmacology; Diterpenes, Abietane - therapeutic use; Gene Expression - drug effects; Gene Expression - genetics; Helicobacter pylori - pathogenicity; Humans; Inflammation - drug therapy; Inflammation - genetics; Inflammation - microbiology; Inflammation Mediators - metabolism; Mice; Mitogen-Activated Protein Kinases - genetics; Mitogen-Activated Protein Kinases - metabolism; NF-kappa B - genetics; NF-kappa B - metabolism; Phytotherapy; RAW 264.7 Cells; Salvia miltiorrhiza - chemistry; Signal Transduction - genetics; Signal Transduction - physiology; Stomach Neoplasms - prevention & control; Tanshinone IIA; Inflammation; Regulation; Helicobacter pylori; Apoptosis

Helicobacter pylori infections induce host cell inflammation and apoptosis, however, they are conflicting. Tanshinone IIA is an active compound of Salvia miltiorrhiza Bge. In this study, we investigated the regulatory effects of tanshinone IIA on H. pylori-induced inflammation and apoptosis in vitro...