Possible impact of impaired double-stranded RNA degradation and nitrosative stress on immuno-inflammatory cascade in type 2 diabetes

• Published in: Experimental and clinical endocrinology & diabetes Vol. 117; no. 9; p. 480
• Main Authors: Kocic, G M, Kocic, R, Pavlovic, R, Jevtovic-Stoimenov, T, Sokolovic, D, Nikolic, G, Pavlovic, V, Stojanovic, S, Basic, J, Veljkovic, A, Pavlovic, D, Kamenov, B
• Format: Journal Article
• Language: English
• Published: Germany 01.10.2009
• Subjects: Adult; Aged; Animals; bcl-2-Associated X Protein - metabolism; Blood Glucose - metabolism; Cells, Cultured; DEAD-box RNA Helicases - metabolism; Diabetes Mellitus, Type 2 - genetics; Diabetes Mellitus, Type 2 - metabolism; Female; Fluorescent Antibody Technique; Humans; Inflammation - genetics; Inflammation - metabolism; Interferon Regulatory Factor-3 - metabolism; Interferon-Induced Helicase, IFIH1; Male; Middle Aged; NF-kappa B - metabolism; Nitrites - blood; Nucleic Acids - blood; Proto-Oncogene Proteins c-bcl-2 - metabolism; Rats; RNA Stability - genetics; RNA, Double-Stranded - genetics; RNA, Double-Stranded - metabolism; Thymus Gland - cytology; Thymus Gland - metabolism; Tyrosine - analogs & derivatives; Tyrosine - blood; Xanthine Oxidase - blood

The immune response can be triggered by molecules derived from microorganisms (PAMP) or from molecules derived from damaged or dead host cells, known as the damage-associated molecular-pattern molecules (DAMP). Their immune effects are accompanied by altered redox environment. The level of stable en...