A new central post-stroke pain rat model: autologous blood injected thalamic hemorrhage involved increased expression of P2X4 receptor
•Behavioral analysis demonstrated that the CPSP animals displayed a significant decrease in mechanical allodynia threshold.•A significant increase in P2 × 4 receptors expression in microglia in thalamic peri-lesion tissues post-hemorrhage.•The mechanical allodynia in rats with CPSP were reversed by b...
Saved in:
| Published in | Neuroscience letters Vol. 687; pp. 124 - 130 |
|---|---|
| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Ireland
Elsevier B.V
20.11.2018
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 0304-3940 1872-7972 1872-7972 |
| DOI | 10.1016/j.neulet.2018.09.023 |
Cover
Loading…
| Abstract | •Behavioral analysis demonstrated that the CPSP animals displayed a significant decrease in mechanical allodynia threshold.•A significant increase in P2 × 4 receptors expression in microglia in thalamic peri-lesion tissues post-hemorrhage.•The mechanical allodynia in rats with CPSP were reversed by blocking P2 × 4 receptors.•A significant alleviation of mechanical allodynia was achieved following the administration of adrenergic antidepressants and antiepileptics.•A significant decrease in P2 × 4 receptor expression after treatment with adrenergic antidepressants and antiepileptics.
Stroke is the leading cause of disability and death in the world. Central post-stroke pain (CPSP), a central neuropathic pain syndrome occurring after cerebral stroke, is a serious problem. But on account of the lack of reliable animal models, the mechanisms underlying CPSP remains poorly understood. To better understand of the pathophysiological basis of CPSP, we developed and characterized a new rat model of CPSP. This model is based on a hemorrhagic stroke lesion with intra-thalamic autologous blood (ITAB) injection in the ventral posterolateral nucleus of the thalamus. Behavioral analysis demonstrated that the animals displayed a significant decrease in mechanical allodynia threshold. We found a significant increase in P2 × 4 receptor expression in microglia in thalamic peri-lesion tissues post-hemorrhage. The mechanical allodynia in rats with CPSP were reversed by blocking P2 × 4 receptors. A significant alleviation of mechanical allodynia was achieved following the administration of adrenergic antidepressants and antiepileptics. Meanwhile, we found a significant decrease in P2 × 4 receptor expression after treatment with these drugs. Taken together, our results suggest that targeting P2 × 4 receptor may be effective in the treatment of CPSP. |
|---|---|
| AbstractList | Stroke is the leading cause of disability and death in the world. Central post-stroke pain (CPSP), a central neuropathic pain syndrome occurring after cerebral stroke, is a serious problem. But on account of the lack of reliable animal models, the mechanisms underlying CPSP remains poorly understood. To better understand of the pathophysiological basis of CPSP, we developed and characterized a new rat model of CPSP. This model is based on a hemorrhagic stroke lesion with intra-thalamic autologous blood (ITAB) injection in the ventral posterolateral nucleus of the thalamus. Behavioral analysis demonstrated that the animals displayed a significant decrease in mechanical allodynia threshold. We found a significant increase in P2 × 4 receptor expression in microglia in thalamic peri-lesion tissues post-hemorrhage. The mechanical allodynia in rats with CPSP were reversed by blocking P2 × 4 receptors. A significant alleviation of mechanical allodynia was achieved following the administration of adrenergic antidepressants and antiepileptics. Meanwhile, we found a significant decrease in P2 × 4 receptor expression after treatment with these drugs. Taken together, our results suggest that targeting P2 × 4 receptor may be effective in the treatment of CPSP.Stroke is the leading cause of disability and death in the world. Central post-stroke pain (CPSP), a central neuropathic pain syndrome occurring after cerebral stroke, is a serious problem. But on account of the lack of reliable animal models, the mechanisms underlying CPSP remains poorly understood. To better understand of the pathophysiological basis of CPSP, we developed and characterized a new rat model of CPSP. This model is based on a hemorrhagic stroke lesion with intra-thalamic autologous blood (ITAB) injection in the ventral posterolateral nucleus of the thalamus. Behavioral analysis demonstrated that the animals displayed a significant decrease in mechanical allodynia threshold. We found a significant increase in P2 × 4 receptor expression in microglia in thalamic peri-lesion tissues post-hemorrhage. The mechanical allodynia in rats with CPSP were reversed by blocking P2 × 4 receptors. A significant alleviation of mechanical allodynia was achieved following the administration of adrenergic antidepressants and antiepileptics. Meanwhile, we found a significant decrease in P2 × 4 receptor expression after treatment with these drugs. Taken together, our results suggest that targeting P2 × 4 receptor may be effective in the treatment of CPSP. Stroke is the leading cause of disability and death in the world. Central post-stroke pain (CPSP), a central neuropathic pain syndrome occurring after cerebral stroke, is a serious problem. But on account of the lack of reliable animal models, the mechanisms underlying CPSP remains poorly understood. To better understand of the pathophysiological basis of CPSP, we developed and characterized a new rat model of CPSP. This model is based on a hemorrhagic stroke lesion with intra-thalamic autologous blood (ITAB) injection in the ventral posterolateral nucleus of the thalamus. Behavioral analysis demonstrated that the animals displayed a significant decrease in mechanical allodynia threshold. We found a significant increase in P2 × 4 receptor expression in microglia in thalamic peri-lesion tissues post-hemorrhage. The mechanical allodynia in rats with CPSP were reversed by blocking P2 × 4 receptors. A significant alleviation of mechanical allodynia was achieved following the administration of adrenergic antidepressants and antiepileptics. Meanwhile, we found a significant decrease in P2 × 4 receptor expression after treatment with these drugs. Taken together, our results suggest that targeting P2 × 4 receptor may be effective in the treatment of CPSP. •Behavioral analysis demonstrated that the CPSP animals displayed a significant decrease in mechanical allodynia threshold.•A significant increase in P2 × 4 receptors expression in microglia in thalamic peri-lesion tissues post-hemorrhage.•The mechanical allodynia in rats with CPSP were reversed by blocking P2 × 4 receptors.•A significant alleviation of mechanical allodynia was achieved following the administration of adrenergic antidepressants and antiepileptics.•A significant decrease in P2 × 4 receptor expression after treatment with adrenergic antidepressants and antiepileptics. Stroke is the leading cause of disability and death in the world. Central post-stroke pain (CPSP), a central neuropathic pain syndrome occurring after cerebral stroke, is a serious problem. But on account of the lack of reliable animal models, the mechanisms underlying CPSP remains poorly understood. To better understand of the pathophysiological basis of CPSP, we developed and characterized a new rat model of CPSP. This model is based on a hemorrhagic stroke lesion with intra-thalamic autologous blood (ITAB) injection in the ventral posterolateral nucleus of the thalamus. Behavioral analysis demonstrated that the animals displayed a significant decrease in mechanical allodynia threshold. We found a significant increase in P2 × 4 receptor expression in microglia in thalamic peri-lesion tissues post-hemorrhage. The mechanical allodynia in rats with CPSP were reversed by blocking P2 × 4 receptors. A significant alleviation of mechanical allodynia was achieved following the administration of adrenergic antidepressants and antiepileptics. Meanwhile, we found a significant decrease in P2 × 4 receptor expression after treatment with these drugs. Taken together, our results suggest that targeting P2 × 4 receptor may be effective in the treatment of CPSP. |
| Author | Xu, Chun-Yang Guo, Xiao-Ning Xu, Guang-Yin Fang, Qi Chen, Chan Gan, Lei Zhang, Yan-Bo Lu, Hai-Feng Ni, Jian-Qiang Zhao, Hong-Ru Zhang, Lei Yan, Man-Yun |
| Author_xml | – sequence: 1 givenname: Hai-Feng surname: Lu fullname: Lu, Hai-Feng organization: Department of Neurology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China – sequence: 2 givenname: Chun-Yang surname: Xu fullname: Xu, Chun-Yang organization: Department of Neurology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China – sequence: 3 givenname: Lei surname: Zhang fullname: Zhang, Lei organization: Department of Neurology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China – sequence: 4 givenname: Lei surname: Gan fullname: Gan, Lei organization: Department of Oncology, The Second Affiliated Hospital of Soochow University, Suzhou 215006, China – sequence: 5 givenname: Chan surname: Chen fullname: Chen, Chan organization: Department of Neurology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China – sequence: 6 givenname: Man-Yun surname: Yan fullname: Yan, Man-Yun organization: Department of Neurology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China – sequence: 7 givenname: Xiao-Ning surname: Guo fullname: Guo, Xiao-Ning organization: Department of Neurology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China – sequence: 8 givenname: Qi surname: Fang fullname: Fang, Qi organization: Department of Neurology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China – sequence: 9 givenname: Guang-Yin surname: Xu fullname: Xu, Guang-Yin organization: Institute of Neuroscience, Soochow University, Suzhou 215123, China – sequence: 10 givenname: Yan-Bo surname: Zhang fullname: Zhang, Yan-Bo organization: Department of Neurology, Affiliated Hospital of Taishan Medical University, Taian 271000, China – sequence: 11 givenname: Jian-Qiang surname: Ni fullname: Ni, Jian-Qiang email: njq@suda.edu.cn organization: Department of Neurology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China – sequence: 12 givenname: Hong-Ru surname: Zhao fullname: Zhao, Hong-Ru email: hongruzhao@suda.edu.cn organization: Department of Neurology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30267847$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkc1u1DAUhS1URKeFN0DISzYJ_ss47gKpqviTKsECJHaWY990PDhxsJ0BXoDnxqNpNyxgda90v3Oke84FOpvjDAg9p6SlhG5f7dsZ1gClZYT2LVEtYfwR2tBeskYqyc7QhnAiGq4EOUcXOe8JIR3txBN0zgnbyl7IDfp9jWf4gS3MJZmAl5hLk0uK3wAvxs84mYKn6CBcYbOWGOJdXDMeQowO-3kPtoDDZWeCmbzFO5hiSjtzB_V4iOEAR8omMLlu8HNJkLOPM44j_sS-CpzAwlJieooejyZkeHY_L9GXt28-37xvbj---3BzfdtYvmWlYX3HpRvV1oLsibFOcG4YZ05aNwxC9QNXihjjpHCUylE5OlLBTD90EqDj_BK9PPkuKX5fIRc9-WwhBDNDfUwzSsVWKalYRV_co-swgdNL8pNJv_RDdhW4OgE2xZwTjNr6Ykp9r0bpg6ZEH4vSe30qSh-L0kTpWlQVi7_ED_7_kb0-yaCGdPCQdLYeZgvO1yiLdtH_2-APy4uxiw |
| CitedBy_id | crossref_primary_10_1155_2022_8958742 crossref_primary_10_1007_s40122_021_00288_3 crossref_primary_10_1016_j_arr_2021_101515 crossref_primary_10_1016_j_neuroscience_2021_10_015 crossref_primary_10_1136_svn_2024_003418 crossref_primary_10_1177_03946320241309220 crossref_primary_10_1007_s11916_020_00887_3 crossref_primary_10_1007_s10571_023_01360_6 crossref_primary_10_3390_brainsci14080741 crossref_primary_10_1016_j_pneurobio_2021_102030 crossref_primary_10_1007_s10787_021_00877_w crossref_primary_10_3389_fneur_2021_667511 crossref_primary_10_1016_j_jpain_2021_02_013 crossref_primary_10_1007_s12035_022_03024_w crossref_primary_10_1007_s12031_022_02011_z crossref_primary_10_1016_j_phrs_2020_104875 |
| Cites_doi | 10.1111/jphp.12007 10.1042/BST0380525 10.1016/S0003-9993(03)00369-1 10.1213/ane.0b013e31819d644c 10.1016/j.neuroscience.2009.03.042 10.1016/S1474-4422(09)70176-0 10.1007/s00018-003-2108-x 10.1016/0304-3959(89)90108-5 10.1016/j.pain.2011.10.029 10.1038/nn1472 10.1016/0165-0270(94)90144-9 10.1080/16501970213237 10.1126/science.1194637 10.1523/JNEUROSCI.5714-08.2009 10.1007/s40263-014-0194-y 10.1254/jphs.12R14CP 10.1002/glia.22516 10.1016/j.coph.2011.10.014 10.1016/S0304-3940(00)01323-9 10.1523/JNEUROSCI.1068-13.2013 10.2183/pjab.93.011 10.1016/j.pain.2008.11.019 10.1016/j.pain.2004.02.002 10.1371/journal.pone.0165189 10.1038/jcbfm.2015.73 10.1016/S0166-2236(00)01854-3 10.1038/nature01868 10.1038/nn.3155 10.1016/S0140-6736(10)60834-3 10.1016/j.it.2005.08.001 10.1016/j.bj.2017.06.010 10.1038/nature04223 10.1016/j.expneurol.2005.09.015 10.1016/j.tips.2007.03.005 10.1016/j.phrs.2011.09.003 10.1523/JNEUROSCI.0716-07.2007 10.1016/j.neures.2013.09.005 10.1007/s00424-006-0064-7 10.1523/JNEUROSCI.2308-08.2008 10.1007/s12264-014-1477-5 10.1016/S0306-4522(03)00228-8 10.1186/1746-6148-9-59 10.1155/2008/754260 10.1111/j.1476-5381.2010.00683.x 10.1016/j.tins.2007.07.007 10.3389/fncel.2013.00191 10.1023/B:JOBB.0000008028.41056.58 10.1038/nature01786 |
| ContentType | Journal Article |
| Copyright | 2018 Elsevier B.V. Copyright © 2018 Elsevier B.V. All rights reserved. |
| Copyright_xml | – notice: 2018 Elsevier B.V. – notice: Copyright © 2018 Elsevier B.V. All rights reserved. |
| DBID | AAYXX CITATION NPM 7X8 |
| DOI | 10.1016/j.neulet.2018.09.023 |
| DatabaseName | CrossRef PubMed MEDLINE - Academic |
| DatabaseTitle | CrossRef PubMed MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic PubMed |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Anatomy & Physiology |
| EISSN | 1872-7972 |
| EndPage | 130 |
| ExternalDocumentID | 30267847 10_1016_j_neulet_2018_09_023 S0304394018306293 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | --- --K --M -~X .~1 0R~ 123 1B1 1RT 1~. 1~5 4.4 457 4G. 53G 5RE 7-5 71M 8P~ 9JM AABNK AACTN AADPK AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAXLA AAXUO ABCQJ ABFNM ABFRF ABJNI ABLJU ABMAC ABYKQ ACDAQ ACGFO ACGFS ACIUM ACRLP ADBBV ADEZE AEBSH AEFWE AEKER AENEX AFKWA AFTJW AFXIZ AGHFR AGUBO AGWIK AGYEJ AIEXJ AIKHN AITUG AJOXV ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ AXJTR BKOJK BLXMC CS3 DU5 EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FIRID FNPLU FYGXN G-Q GBLVA IHE J1W KOM M2V M41 MO0 MOBAO N9A O-L O9- OAUVE OZT P-8 P-9 P2P PC. Q38 RIG ROL RPZ SCC SDF SDG SDP SES SPCBC SSN SSZ T5K WH7 YCJ ~G- .55 .GJ 29N 5VS AAEDT AAQFI AAQXK AATTM AAXKI AAYWO AAYXX ABWVN ABXDB ACRPL ACVFH ADCNI ADIYS ADMUD ADNMO AEIPS AETEA AEUPX AFJKZ AFPUW AGCQF AGQPQ AGRNS AHHHB AIGII AIIUN AKBMS AKRWK AKYEP ANKPU APXCP ASPBG AVWKF AZFZN BNPGV CITATION FEDTE FGOYB G-2 HMQ HVGLF HZ~ MVM R2- SEW SNS SSH WUQ X7M ZGI ZXP ZY4 NPM 7X8 EFKBS |
| ID | FETCH-LOGICAL-c362t-28537df96ce780acd433a232d7cdbb498b3990aad74d117f9d1f142a8b57ee533 |
| IEDL.DBID | .~1 |
| ISSN | 0304-3940 1872-7972 |
| IngestDate | Tue Aug 05 10:57:00 EDT 2025 Wed Feb 19 02:36:14 EST 2025 Tue Jul 01 01:43:55 EDT 2025 Thu Apr 24 23:12:52 EDT 2025 Fri Feb 23 02:49:04 EST 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | Central post-stroke pain Autologous blood P2X4 |
| Language | English |
| License | Copyright © 2018 Elsevier B.V. All rights reserved. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c362t-28537df96ce780acd433a232d7cdbb498b3990aad74d117f9d1f142a8b57ee533 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| PMID | 30267847 |
| PQID | 2114699792 |
| PQPubID | 23479 |
| PageCount | 7 |
| ParticipantIDs | proquest_miscellaneous_2114699792 pubmed_primary_30267847 crossref_citationtrail_10_1016_j_neulet_2018_09_023 crossref_primary_10_1016_j_neulet_2018_09_023 elsevier_sciencedirect_doi_10_1016_j_neulet_2018_09_023 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2018-11-20 |
| PublicationDateYYYYMMDD | 2018-11-20 |
| PublicationDate_xml | – month: 11 year: 2018 text: 2018-11-20 day: 20 |
| PublicationDecade | 2010 |
| PublicationPlace | Ireland |
| PublicationPlace_xml | – name: Ireland |
| PublicationTitle | Neuroscience letters |
| PublicationTitleAlternate | Neurosci Lett |
| PublicationYear | 2018 |
| Publisher | Elsevier B.V |
| Publisher_xml | – name: Elsevier B.V |
| References | Davies, Hendrich, Van Minh, Wratten, Douglas, Dolphin (bib0215) 2007; 28 Klit, Finnerup, Jensen (bib0190) 2009; 8 Kim, Greenspan, Coghill, Ohara, Lenz (bib0155) 2007; 27 Greenspan, Ohara, Sarlani, Lenz (bib0020) 2004; 109 Abbadie (bib0080) 2005; 26 Inoue (bib0170) 2017; 93 Blasi, Herisson, Wang, Mao, Ayata (bib0140) 2015; 35 Tsuda, Tozaki-Saitoh, Inoue (bib0165) 2012; 12 Maneuf, Gonzalez, Sutton, Chung, Pinnock, Lee (bib0225) 2003; 60 Tsuda, Masuda, Tozaki-Saitoh, Inoue (bib0040) 2013; 121 Castel, Helie, Beaudry, Vachon (bib0145) 2013; 9 Watkins, Milligan, Maier (bib0035) 2001; 24 Bauer, Rahman, Tran-van-Minh, Lujan, Dickenson, Dolphin (bib0230) 2010; 38 Kong, Woon, Yang (bib0015) 2004; 85 Farber, Kettenmann (bib0060) 2006; 452 Siniscalchi, Gallelli, De Sarro, Malferrari, Santangelo (bib0200) 2012; 65 Casey, Geisser, Lorenz, Morrow, Paulson, Minoshima (bib0150) 2012; 153 Kim (bib0120) 2014; 28 Zhang, Artelt, Burnet, Trautmann, Schluesener (bib0085) 2006; 197 Yang, Fu, Lu, Wang, Yang, Yang, Yu, Sun, Wang, Costigan, Chen (bib0110) 2014; 30 Klugbauer, Marais, Hofmann (bib0220) 2003; 35 Tamiya, Yoshida, Harada, Nakamoto, Tokuyama (bib0135) 2013; 65 Kumar, Kalita, Kumar, Misra (bib0195) 2009; 108 O’Donnell, Xavier, Liu, Zhang, Chin, Rao-Melacini, Rangarajan, Islam, Pais, McQueen, Mondo, Damasceno, Lopez-Jaramillo, Hankey, Dans, Yusoff, Truelsen, Diener, Sacco, Ryglewicz, Czlonkowska, Weimar, Wang, Yusuf, investigators (bib0005) 2010; 376 Coull, Boudreau, Bachand, Prescott, Nault, Sik, De Koninck, De Koninck (bib0185) 2003; 424 Pocock, Kettenmann (bib0055) 2007; 30 Sim, North (bib0240) 2010; 160 Ulmann, Hatcher, Hughes, Chaumont, Green, Conquet, Buell, Reeve, Chessell, Rassendren (bib0070) 2008; 28 Suurvali, Boudinot, Kanellopoulos, Ruutel Boudinot (bib0175) 2017; 40 Davalos, Grutzendler, Yang, Kim, Zuo, Jung, Littman, Dustin, Gan (bib0050) 2005; 8 Tsuda, Masuda, Tozaki-Saitoh, Inoue (bib0115) 2013; 7 Ulmann, Levavasseur, Avignone, Peyroutou, Hirbec, Audinat, Rassendren (bib0095) 2013; 61 Wasserman, Koeberle (bib0130) 2009; 161 Hanada, Kurihara, Tokudome, Tokimura, Arita, Miyata (bib0210) 2014; 78 Trang, Beggs, Wan, Salter (bib0075) 2009; 29 Coull, Beggs, Boudreau, Boivin, Tsuda, Inoue, Gravel, Salter, De Koninck (bib0180) 2005; 438 Beggs, Trang, Salter (bib0025) 2012; 15 Yamashita, Yamamoto, Zhang, Kometani, Tomiyama, Kohno, Tozaki-Saitoh, Inoue, Tsuda (bib0245) 2016; 11 Ginhoux, Greter, Leboeuf, Nandi, See, Gokhan, Mehler, Conway, Ng, Stanley, Samokhvalov, Merad (bib0045) 2010; 330 Chaplan, Bach, Pogrel, Chung, Yaksh (bib0100) 1994; 53 Widar, Samuelsson, Karlsson-Tivenius, Ahlstrom (bib0010) 2002; 34 Henry, Lalloo, Yashpal (bib0030) 2008; 13 Leijon, Boivie (bib0205) 1989; 36 Zhang, Hu, Zhou, Hu, Wang, Chen, Xiao, Huang, Jiang, Xu (bib0105) 2013; 33 Taylor (bib0235) 2009; 142 Bernier, Ase, Seguela (bib0160) 2017 Tsuda, Shigemoto-Mogami, Koizumi, Mizokoshi, Kohsaka, Salter, Inoue (bib0065) 2003; 424 Cavaliere, Florenzano, Amadio, Fusco, Viscomi, D’Ambrosi, Vacca, Sancesario, Bernardi, Molinari, Volonte (bib0090) 2003; 120 LaBuda, Cutler, Dougherty, Fuchs (bib0125) 2000; 290 Cavaliere (10.1016/j.neulet.2018.09.023_bib0090) 2003; 120 Wasserman (10.1016/j.neulet.2018.09.023_bib0130) 2009; 161 Castel (10.1016/j.neulet.2018.09.023_bib0145) 2013; 9 Kong (10.1016/j.neulet.2018.09.023_bib0015) 2004; 85 Abbadie (10.1016/j.neulet.2018.09.023_bib0080) 2005; 26 Watkins (10.1016/j.neulet.2018.09.023_bib0035) 2001; 24 Klit (10.1016/j.neulet.2018.09.023_bib0190) 2009; 8 Kumar (10.1016/j.neulet.2018.09.023_bib0195) 2009; 108 Ginhoux (10.1016/j.neulet.2018.09.023_bib0045) 2010; 330 Bauer (10.1016/j.neulet.2018.09.023_bib0230) 2010; 38 Henry (10.1016/j.neulet.2018.09.023_bib0030) 2008; 13 Kim (10.1016/j.neulet.2018.09.023_bib0120) 2014; 28 Leijon (10.1016/j.neulet.2018.09.023_bib0205) 1989; 36 O’Donnell (10.1016/j.neulet.2018.09.023_bib0005) 2010; 376 Hanada (10.1016/j.neulet.2018.09.023_bib0210) 2014; 78 Widar (10.1016/j.neulet.2018.09.023_bib0010) 2002; 34 Tamiya (10.1016/j.neulet.2018.09.023_bib0135) 2013; 65 Bernier (10.1016/j.neulet.2018.09.023_bib0160) 2017 Sim (10.1016/j.neulet.2018.09.023_bib0240) 2010; 160 Klugbauer (10.1016/j.neulet.2018.09.023_bib0220) 2003; 35 Trang (10.1016/j.neulet.2018.09.023_bib0075) 2009; 29 Tsuda (10.1016/j.neulet.2018.09.023_bib0040) 2013; 121 Yang (10.1016/j.neulet.2018.09.023_bib0110) 2014; 30 Tsuda (10.1016/j.neulet.2018.09.023_bib0065) 2003; 424 Davalos (10.1016/j.neulet.2018.09.023_bib0050) 2005; 8 Beggs (10.1016/j.neulet.2018.09.023_bib0025) 2012; 15 LaBuda (10.1016/j.neulet.2018.09.023_bib0125) 2000; 290 Farber (10.1016/j.neulet.2018.09.023_bib0060) 2006; 452 Taylor (10.1016/j.neulet.2018.09.023_bib0235) 2009; 142 Tsuda (10.1016/j.neulet.2018.09.023_bib0115) 2013; 7 Suurvali (10.1016/j.neulet.2018.09.023_bib0175) 2017; 40 Kim (10.1016/j.neulet.2018.09.023_bib0155) 2007; 27 Inoue (10.1016/j.neulet.2018.09.023_bib0170) 2017; 93 Ulmann (10.1016/j.neulet.2018.09.023_bib0070) 2008; 28 Greenspan (10.1016/j.neulet.2018.09.023_bib0020) 2004; 109 Zhang (10.1016/j.neulet.2018.09.023_bib0105) 2013; 33 Chaplan (10.1016/j.neulet.2018.09.023_bib0100) 1994; 53 Maneuf (10.1016/j.neulet.2018.09.023_bib0225) 2003; 60 Siniscalchi (10.1016/j.neulet.2018.09.023_bib0200) 2012; 65 Casey (10.1016/j.neulet.2018.09.023_bib0150) 2012; 153 Pocock (10.1016/j.neulet.2018.09.023_bib0055) 2007; 30 Yamashita (10.1016/j.neulet.2018.09.023_bib0245) 2016; 11 Tsuda (10.1016/j.neulet.2018.09.023_bib0165) 2012; 12 Zhang (10.1016/j.neulet.2018.09.023_bib0085) 2006; 197 Ulmann (10.1016/j.neulet.2018.09.023_bib0095) 2013; 61 Coull (10.1016/j.neulet.2018.09.023_bib0180) 2005; 438 Davies (10.1016/j.neulet.2018.09.023_bib0215) 2007; 28 Coull (10.1016/j.neulet.2018.09.023_bib0185) 2003; 424 Blasi (10.1016/j.neulet.2018.09.023_bib0140) 2015; 35 |
| References_xml | – volume: 11 year: 2016 ident: bib0245 article-title: Duloxetine inhibits microglial P2X4 receptor function and alleviates neuropathic pain after peripheral nerve injury publication-title: PLoS One – volume: 35 start-page: 1100 year: 2015 end-page: 1103 ident: bib0140 article-title: Late-onset thermal hypersensitivity after focal ischemic thalamic infarcts as a model for central post-stroke pain in rats publication-title: J. Cereb. Blood Flow Metab. – volume: 424 start-page: 938 year: 2003 end-page: 942 ident: bib0185 article-title: Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain publication-title: Nature – volume: 60 start-page: 742 year: 2003 end-page: 750 ident: bib0225 article-title: Cellular and molecular action of the putative GABA-mimetic, gabapentin publication-title: Cell. Mol. Life Sci. – volume: 161 start-page: 173 year: 2009 end-page: 183 ident: bib0130 article-title: Development and characterization of a hemorrhagic rat model of central post-stroke pain publication-title: Neuroscience – volume: 28 start-page: 220 year: 2007 end-page: 228 ident: bib0215 article-title: Functional biology of the alpha(2)delta subunits of voltage-gated calcium channels publication-title: Trends Pharmacol. Sci. – volume: 65 start-page: 615 year: 2013 end-page: 620 ident: bib0135 article-title: Establishment of a central post-stroke pain model using global cerebral ischaemic mice publication-title: J. Pharm. Pharmacol. – volume: 15 start-page: 1068 year: 2012 end-page: 1073 ident: bib0025 article-title: P2X4R+ microglia drive neuropathic pain publication-title: Nat. Neurosci. – volume: 376 start-page: 112 year: 2010 end-page: 123 ident: bib0005 article-title: Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study): a case-control study publication-title: Lancet – volume: 26 start-page: 529 year: 2005 end-page: 534 ident: bib0080 article-title: Chemokines, chemokine receptors and pain publication-title: Trends Immunol. – volume: 40 start-page: 245 year: 2017 end-page: 256 ident: bib0175 article-title: P2X4: a fast and sensitive purinergic receptor publication-title: Biomed. J. – volume: 33 start-page: 9028 year: 2013 end-page: 9038 ident: bib0105 article-title: Promoted interaction of nuclear factor-kappaB with demethylated cystathionine-beta-synthetase gene contributes to gastric hypersensitivity in diabetic rats publication-title: J. Neurosci. – volume: 438 start-page: 1017 year: 2005 end-page: 1021 ident: bib0180 article-title: BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain publication-title: Nature – volume: 30 start-page: 527 year: 2007 end-page: 535 ident: bib0055 article-title: Neurotransmitter receptors on microglia publication-title: Trends Neurosci. – volume: 13 start-page: 41 year: 2008 end-page: 49 ident: bib0030 article-title: Central poststroke pain: an abstruse outcome publication-title: Pain Res. Manage. – volume: 78 start-page: 72 year: 2014 end-page: 80 ident: bib0210 article-title: Development and pharmacological verification of a new mouse model of central post-stroke pain publication-title: Neurosci. Res. – volume: 38 start-page: 525 year: 2010 end-page: 528 ident: bib0230 article-title: The anti-allodynic alpha(2)delta ligand pregabalin inhibits the trafficking of the calcium channel alpha(2)delta-1 subunit to presynaptic terminals in vivo publication-title: Biochem. Soc. Trans. – volume: 452 start-page: 615 year: 2006 end-page: 621 ident: bib0060 article-title: Purinergic signaling and microglia publication-title: Pflugers Arch. – year: 2017 ident: bib0160 article-title: P2X receptor channels in chronic pain pathways publication-title: Br. J. Pharmacol. – volume: 93 start-page: 174 year: 2017 end-page: 182 ident: bib0170 article-title: Purinergic signaling in microglia in the pathogenesis of neuropathic pain publication-title: Proc. Jpn. Acad. Ser. B Phys. Biol. Sci. – volume: 27 start-page: 4995 year: 2007 end-page: 5004 ident: bib0155 article-title: Lesions limited to the human thalamic principal somatosensory nucleus (ventral caudal) are associated with loss of cold sensations and central pain publication-title: J. Neurosci. – volume: 61 start-page: 1306 year: 2013 end-page: 1319 ident: bib0095 article-title: Involvement of P2X4 receptors in hippocampal microglial activation after status epilepticus publication-title: Glia – volume: 9 start-page: 59 year: 2013 ident: bib0145 article-title: Bilateral central pain sensitization in rats following a unilateral thalamic lesion may be treated with high doses of ketamine publication-title: BMC Vet. Res. – volume: 24 start-page: 450 year: 2001 end-page: 455 ident: bib0035 article-title: Glial activation: a driving force for pathological pain publication-title: Trends Neurosci. – volume: 85 start-page: 35 year: 2004 end-page: 40 ident: bib0015 article-title: Prevalence of chronic pain and its impact on health-related quality of life in stroke survivors publication-title: Arch. Phys. Med. Rehabil. – volume: 29 start-page: 3518 year: 2009 end-page: 3528 ident: bib0075 article-title: P2X4-receptor-mediated synthesis and release of brain-derived neurotrophic factor in microglia is dependent on calcium and p38-mitogen-activated protein kinase activation publication-title: J. Neurosci. – volume: 160 start-page: 88 year: 2010 end-page: 92 ident: bib0240 article-title: Amitriptyline does not block the action of ATP at human P2X4 receptor publication-title: Br. J. Pharmacol. – volume: 7 start-page: 191 year: 2013 ident: bib0115 article-title: P2X4 receptors and neuropathic pain publication-title: Front. Cell. Neurosci. – volume: 108 start-page: 1645 year: 2009 end-page: 1657 ident: bib0195 article-title: Central poststroke pain: a review of pathophysiology and treatment publication-title: Anesth. Analg. – volume: 36 start-page: 27 year: 1989 end-page: 36 ident: bib0205 article-title: Central post-stroke pain—a controlled trial of amitriptyline and carbamazepine publication-title: Pain – volume: 197 start-page: 252 year: 2006 end-page: 257 ident: bib0085 article-title: Lesional accumulation of P2X4 receptor+ monocytes following experimental traumatic brain injury publication-title: Exp. Neurol. – volume: 290 start-page: 79 year: 2000 end-page: 83 ident: bib0125 article-title: Mechanical and thermal hypersensitivity develops following kainate lesion of the ventral posterior lateral thalamus in rats publication-title: Neurosci. Lett. – volume: 109 start-page: 357 year: 2004 end-page: 366 ident: bib0020 article-title: Allodynia in patients with post-stroke central pain (CPSP) studied by statistical quantitative sensory testing within individuals publication-title: Pain – volume: 330 start-page: 841 year: 2010 end-page: 845 ident: bib0045 article-title: Fate mapping analysis reveals that adult microglia derive from primitive macrophages publication-title: Science – volume: 34 start-page: 165 year: 2002 end-page: 170 ident: bib0010 article-title: Long-term pain conditions after a stroke publication-title: J. Rehabil. Med. – volume: 8 start-page: 857 year: 2009 end-page: 868 ident: bib0190 article-title: Central post-stroke pain: clinical characteristics, pathophysiology, and management publication-title: Lancet Neurol. – volume: 53 start-page: 55 year: 1994 end-page: 63 ident: bib0100 article-title: Quantitative assessment of tactile allodynia in the rat paw publication-title: J. Neurosci. Methods – volume: 30 start-page: 887 year: 2014 end-page: 902 ident: bib0110 article-title: Post-stroke pain hypersensitivity induced by experimental thalamic hemorrhage in rats is region-specific and demonstrates limited efficacy of gabapentin publication-title: Neurosci. Bull. – volume: 153 start-page: 331 year: 2012 end-page: 341 ident: bib0150 article-title: Psychophysical and cerebral responses to heat stimulation in patients with central pain, painless central sensory loss, and in healthy persons publication-title: Pain – volume: 65 start-page: 171 year: 2012 end-page: 175 ident: bib0200 article-title: Antiepileptic drugs for central post-stroke pain management publication-title: Pharmacol. Res. – volume: 35 start-page: 639 year: 2003 end-page: 647 ident: bib0220 article-title: Calcium channel alpha2delta subunits: differential expression, function, and drug binding publication-title: J. Bioenergy Biomembr. – volume: 120 start-page: 85 year: 2003 end-page: 98 ident: bib0090 article-title: Up-regulation of P2X2, P2X4 receptor and ischemic cell death: prevention by P2 antagonists publication-title: Neuroscience – volume: 142 start-page: 13 year: 2009 end-page: 16 ident: bib0235 article-title: Mechanisms of analgesia by gabapentin and pregabalin--calcium channel alpha2-delta [Cavalpha2-delta] ligands publication-title: Pain – volume: 424 start-page: 778 year: 2003 end-page: 783 ident: bib0065 article-title: P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury publication-title: Nature – volume: 12 start-page: 74 year: 2012 end-page: 79 ident: bib0165 article-title: Purinergic system, microglia and neuropathic pain publication-title: Curr. Opin. Pharmacol. – volume: 28 start-page: 11263 year: 2008 end-page: 11268 ident: bib0070 article-title: Up-regulation of P2X4 receptors in spinal microglia after peripheral nerve injury mediates BDNF release and neuropathic pain publication-title: J. Neurosci. – volume: 121 start-page: 89 year: 2013 end-page: 94 ident: bib0040 article-title: Microglial regulation of neuropathic pain publication-title: J. Pharmacol. Sci. – volume: 8 start-page: 752 year: 2005 end-page: 758 ident: bib0050 article-title: ATP mediates rapid microglial response to local brain injury in vivo publication-title: Nat. Neurosci. – volume: 28 start-page: 787 year: 2014 end-page: 797 ident: bib0120 article-title: Pharmacological management of central post-stroke pain: a practical guide publication-title: CNS Drugs – year: 2017 ident: 10.1016/j.neulet.2018.09.023_bib0160 article-title: P2X receptor channels in chronic pain pathways publication-title: Br. J. Pharmacol. – volume: 65 start-page: 615 year: 2013 ident: 10.1016/j.neulet.2018.09.023_bib0135 article-title: Establishment of a central post-stroke pain model using global cerebral ischaemic mice publication-title: J. Pharm. Pharmacol. doi: 10.1111/jphp.12007 – volume: 38 start-page: 525 year: 2010 ident: 10.1016/j.neulet.2018.09.023_bib0230 article-title: The anti-allodynic alpha(2)delta ligand pregabalin inhibits the trafficking of the calcium channel alpha(2)delta-1 subunit to presynaptic terminals in vivo publication-title: Biochem. Soc. Trans. doi: 10.1042/BST0380525 – volume: 85 start-page: 35 year: 2004 ident: 10.1016/j.neulet.2018.09.023_bib0015 article-title: Prevalence of chronic pain and its impact on health-related quality of life in stroke survivors publication-title: Arch. Phys. Med. Rehabil. doi: 10.1016/S0003-9993(03)00369-1 – volume: 108 start-page: 1645 year: 2009 ident: 10.1016/j.neulet.2018.09.023_bib0195 article-title: Central poststroke pain: a review of pathophysiology and treatment publication-title: Anesth. Analg. doi: 10.1213/ane.0b013e31819d644c – volume: 161 start-page: 173 year: 2009 ident: 10.1016/j.neulet.2018.09.023_bib0130 article-title: Development and characterization of a hemorrhagic rat model of central post-stroke pain publication-title: Neuroscience doi: 10.1016/j.neuroscience.2009.03.042 – volume: 8 start-page: 857 year: 2009 ident: 10.1016/j.neulet.2018.09.023_bib0190 article-title: Central post-stroke pain: clinical characteristics, pathophysiology, and management publication-title: Lancet Neurol. doi: 10.1016/S1474-4422(09)70176-0 – volume: 60 start-page: 742 year: 2003 ident: 10.1016/j.neulet.2018.09.023_bib0225 article-title: Cellular and molecular action of the putative GABA-mimetic, gabapentin publication-title: Cell. Mol. Life Sci. doi: 10.1007/s00018-003-2108-x – volume: 36 start-page: 27 year: 1989 ident: 10.1016/j.neulet.2018.09.023_bib0205 article-title: Central post-stroke pain—a controlled trial of amitriptyline and carbamazepine publication-title: Pain doi: 10.1016/0304-3959(89)90108-5 – volume: 153 start-page: 331 year: 2012 ident: 10.1016/j.neulet.2018.09.023_bib0150 article-title: Psychophysical and cerebral responses to heat stimulation in patients with central pain, painless central sensory loss, and in healthy persons publication-title: Pain doi: 10.1016/j.pain.2011.10.029 – volume: 8 start-page: 752 year: 2005 ident: 10.1016/j.neulet.2018.09.023_bib0050 article-title: ATP mediates rapid microglial response to local brain injury in vivo publication-title: Nat. Neurosci. doi: 10.1038/nn1472 – volume: 53 start-page: 55 year: 1994 ident: 10.1016/j.neulet.2018.09.023_bib0100 article-title: Quantitative assessment of tactile allodynia in the rat paw publication-title: J. Neurosci. Methods doi: 10.1016/0165-0270(94)90144-9 – volume: 34 start-page: 165 year: 2002 ident: 10.1016/j.neulet.2018.09.023_bib0010 article-title: Long-term pain conditions after a stroke publication-title: J. Rehabil. Med. doi: 10.1080/16501970213237 – volume: 330 start-page: 841 year: 2010 ident: 10.1016/j.neulet.2018.09.023_bib0045 article-title: Fate mapping analysis reveals that adult microglia derive from primitive macrophages publication-title: Science doi: 10.1126/science.1194637 – volume: 29 start-page: 3518 year: 2009 ident: 10.1016/j.neulet.2018.09.023_bib0075 article-title: P2X4-receptor-mediated synthesis and release of brain-derived neurotrophic factor in microglia is dependent on calcium and p38-mitogen-activated protein kinase activation publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.5714-08.2009 – volume: 28 start-page: 787 year: 2014 ident: 10.1016/j.neulet.2018.09.023_bib0120 article-title: Pharmacological management of central post-stroke pain: a practical guide publication-title: CNS Drugs doi: 10.1007/s40263-014-0194-y – volume: 121 start-page: 89 year: 2013 ident: 10.1016/j.neulet.2018.09.023_bib0040 article-title: Microglial regulation of neuropathic pain publication-title: J. Pharmacol. Sci. doi: 10.1254/jphs.12R14CP – volume: 61 start-page: 1306 year: 2013 ident: 10.1016/j.neulet.2018.09.023_bib0095 article-title: Involvement of P2X4 receptors in hippocampal microglial activation after status epilepticus publication-title: Glia doi: 10.1002/glia.22516 – volume: 12 start-page: 74 year: 2012 ident: 10.1016/j.neulet.2018.09.023_bib0165 article-title: Purinergic system, microglia and neuropathic pain publication-title: Curr. Opin. Pharmacol. doi: 10.1016/j.coph.2011.10.014 – volume: 290 start-page: 79 year: 2000 ident: 10.1016/j.neulet.2018.09.023_bib0125 article-title: Mechanical and thermal hypersensitivity develops following kainate lesion of the ventral posterior lateral thalamus in rats publication-title: Neurosci. Lett. doi: 10.1016/S0304-3940(00)01323-9 – volume: 33 start-page: 9028 year: 2013 ident: 10.1016/j.neulet.2018.09.023_bib0105 article-title: Promoted interaction of nuclear factor-kappaB with demethylated cystathionine-beta-synthetase gene contributes to gastric hypersensitivity in diabetic rats publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.1068-13.2013 – volume: 93 start-page: 174 year: 2017 ident: 10.1016/j.neulet.2018.09.023_bib0170 article-title: Purinergic signaling in microglia in the pathogenesis of neuropathic pain publication-title: Proc. Jpn. Acad. Ser. B Phys. Biol. Sci. doi: 10.2183/pjab.93.011 – volume: 142 start-page: 13 year: 2009 ident: 10.1016/j.neulet.2018.09.023_bib0235 article-title: Mechanisms of analgesia by gabapentin and pregabalin--calcium channel alpha2-delta [Cavalpha2-delta] ligands publication-title: Pain doi: 10.1016/j.pain.2008.11.019 – volume: 109 start-page: 357 year: 2004 ident: 10.1016/j.neulet.2018.09.023_bib0020 article-title: Allodynia in patients with post-stroke central pain (CPSP) studied by statistical quantitative sensory testing within individuals publication-title: Pain doi: 10.1016/j.pain.2004.02.002 – volume: 11 year: 2016 ident: 10.1016/j.neulet.2018.09.023_bib0245 article-title: Duloxetine inhibits microglial P2X4 receptor function and alleviates neuropathic pain after peripheral nerve injury publication-title: PLoS One doi: 10.1371/journal.pone.0165189 – volume: 35 start-page: 1100 year: 2015 ident: 10.1016/j.neulet.2018.09.023_bib0140 article-title: Late-onset thermal hypersensitivity after focal ischemic thalamic infarcts as a model for central post-stroke pain in rats publication-title: J. Cereb. Blood Flow Metab. doi: 10.1038/jcbfm.2015.73 – volume: 24 start-page: 450 year: 2001 ident: 10.1016/j.neulet.2018.09.023_bib0035 article-title: Glial activation: a driving force for pathological pain publication-title: Trends Neurosci. doi: 10.1016/S0166-2236(00)01854-3 – volume: 424 start-page: 938 year: 2003 ident: 10.1016/j.neulet.2018.09.023_bib0185 article-title: Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain publication-title: Nature doi: 10.1038/nature01868 – volume: 15 start-page: 1068 year: 2012 ident: 10.1016/j.neulet.2018.09.023_bib0025 article-title: P2X4R+ microglia drive neuropathic pain publication-title: Nat. Neurosci. doi: 10.1038/nn.3155 – volume: 376 start-page: 112 year: 2010 ident: 10.1016/j.neulet.2018.09.023_bib0005 article-title: Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study): a case-control study publication-title: Lancet doi: 10.1016/S0140-6736(10)60834-3 – volume: 26 start-page: 529 year: 2005 ident: 10.1016/j.neulet.2018.09.023_bib0080 article-title: Chemokines, chemokine receptors and pain publication-title: Trends Immunol. doi: 10.1016/j.it.2005.08.001 – volume: 40 start-page: 245 year: 2017 ident: 10.1016/j.neulet.2018.09.023_bib0175 article-title: P2X4: a fast and sensitive purinergic receptor publication-title: Biomed. J. doi: 10.1016/j.bj.2017.06.010 – volume: 438 start-page: 1017 year: 2005 ident: 10.1016/j.neulet.2018.09.023_bib0180 article-title: BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain publication-title: Nature doi: 10.1038/nature04223 – volume: 197 start-page: 252 year: 2006 ident: 10.1016/j.neulet.2018.09.023_bib0085 article-title: Lesional accumulation of P2X4 receptor+ monocytes following experimental traumatic brain injury publication-title: Exp. Neurol. doi: 10.1016/j.expneurol.2005.09.015 – volume: 28 start-page: 220 year: 2007 ident: 10.1016/j.neulet.2018.09.023_bib0215 article-title: Functional biology of the alpha(2)delta subunits of voltage-gated calcium channels publication-title: Trends Pharmacol. Sci. doi: 10.1016/j.tips.2007.03.005 – volume: 65 start-page: 171 year: 2012 ident: 10.1016/j.neulet.2018.09.023_bib0200 article-title: Antiepileptic drugs for central post-stroke pain management publication-title: Pharmacol. Res. doi: 10.1016/j.phrs.2011.09.003 – volume: 27 start-page: 4995 year: 2007 ident: 10.1016/j.neulet.2018.09.023_bib0155 article-title: Lesions limited to the human thalamic principal somatosensory nucleus (ventral caudal) are associated with loss of cold sensations and central pain publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.0716-07.2007 – volume: 78 start-page: 72 year: 2014 ident: 10.1016/j.neulet.2018.09.023_bib0210 article-title: Development and pharmacological verification of a new mouse model of central post-stroke pain publication-title: Neurosci. Res. doi: 10.1016/j.neures.2013.09.005 – volume: 452 start-page: 615 year: 2006 ident: 10.1016/j.neulet.2018.09.023_bib0060 article-title: Purinergic signaling and microglia publication-title: Pflugers Arch. doi: 10.1007/s00424-006-0064-7 – volume: 28 start-page: 11263 year: 2008 ident: 10.1016/j.neulet.2018.09.023_bib0070 article-title: Up-regulation of P2X4 receptors in spinal microglia after peripheral nerve injury mediates BDNF release and neuropathic pain publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.2308-08.2008 – volume: 30 start-page: 887 year: 2014 ident: 10.1016/j.neulet.2018.09.023_bib0110 article-title: Post-stroke pain hypersensitivity induced by experimental thalamic hemorrhage in rats is region-specific and demonstrates limited efficacy of gabapentin publication-title: Neurosci. Bull. doi: 10.1007/s12264-014-1477-5 – volume: 120 start-page: 85 year: 2003 ident: 10.1016/j.neulet.2018.09.023_bib0090 article-title: Up-regulation of P2X2, P2X4 receptor and ischemic cell death: prevention by P2 antagonists publication-title: Neuroscience doi: 10.1016/S0306-4522(03)00228-8 – volume: 9 start-page: 59 year: 2013 ident: 10.1016/j.neulet.2018.09.023_bib0145 article-title: Bilateral central pain sensitization in rats following a unilateral thalamic lesion may be treated with high doses of ketamine publication-title: BMC Vet. Res. doi: 10.1186/1746-6148-9-59 – volume: 13 start-page: 41 year: 2008 ident: 10.1016/j.neulet.2018.09.023_bib0030 article-title: Central poststroke pain: an abstruse outcome publication-title: Pain Res. Manage. doi: 10.1155/2008/754260 – volume: 160 start-page: 88 year: 2010 ident: 10.1016/j.neulet.2018.09.023_bib0240 article-title: Amitriptyline does not block the action of ATP at human P2X4 receptor publication-title: Br. J. Pharmacol. doi: 10.1111/j.1476-5381.2010.00683.x – volume: 30 start-page: 527 year: 2007 ident: 10.1016/j.neulet.2018.09.023_bib0055 article-title: Neurotransmitter receptors on microglia publication-title: Trends Neurosci. doi: 10.1016/j.tins.2007.07.007 – volume: 7 start-page: 191 year: 2013 ident: 10.1016/j.neulet.2018.09.023_bib0115 article-title: P2X4 receptors and neuropathic pain publication-title: Front. Cell. Neurosci. doi: 10.3389/fncel.2013.00191 – volume: 35 start-page: 639 year: 2003 ident: 10.1016/j.neulet.2018.09.023_bib0220 article-title: Calcium channel alpha2delta subunits: differential expression, function, and drug binding publication-title: J. Bioenergy Biomembr. doi: 10.1023/B:JOBB.0000008028.41056.58 – volume: 424 start-page: 778 year: 2003 ident: 10.1016/j.neulet.2018.09.023_bib0065 article-title: P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury publication-title: Nature doi: 10.1038/nature01786 |
| SSID | ssj0005154 |
| Score | 2.3577518 |
| Snippet | •Behavioral analysis demonstrated that the CPSP animals displayed a significant decrease in mechanical allodynia threshold.•A significant increase in P2 × 4... Stroke is the leading cause of disability and death in the world. Central post-stroke pain (CPSP), a central neuropathic pain syndrome occurring after cerebral... |
| SourceID | proquest pubmed crossref elsevier |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 124 |
| SubjectTerms | Autologous blood Central post-stroke pain P2X4 |
| Title | A new central post-stroke pain rat model: autologous blood injected thalamic hemorrhage involved increased expression of P2X4 receptor |
| URI | https://dx.doi.org/10.1016/j.neulet.2018.09.023 https://www.ncbi.nlm.nih.gov/pubmed/30267847 https://www.proquest.com/docview/2114699792 |
| Volume | 687 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELaqIiEuCFoeS6EyEuIWNomddcxtVVEtoFZIUGlvll_RLhQn2s2icuHI72bGcSo4VJVQLnnYSuQZz3yOv5kh5NWs9tKUrMoKz3TGbcNxSoExZE2lHRxFTOpzdj5bXPAPy2q5R07GWBikVSbbP9j0aK3TnWkazWm3Xk8_46Ye1vUGpcxn4LUwgp0LpPW9-fUXzaOohhRSuAMArcfwucjxCn4Ho4MErzpmOy3ZTe7pJvgZ3dDpA3I_4Uc6Hz7xIdnz4YAczgOsnb__pK9pZHTGX-UH5O5Z2jg_JL_nFPAzTVRM2rXbPtv2m_abp51eBwp6QGNRnLdU72JJ23a3pZHVTtcB_9V4R_uVvsTy9XSF9NzNCkwRPAT79sNjK8SfWzjzV4lcG2jb0E_lklMYYt_B6v4RuTh99-VkkaUSDJkFz9ZnJXhz4Ro5s17UubaOM6YBhDlhnTFc1gYATq61E9yBiBvpiqbgpa5NJbwHKPmY7Ic2-KeEMmaNs8Lo2tZcwqoQU5AaJ7UDs2GYnxA2jryyKT85lsm4VCMR7asa5KVQXiqXCuQ1Idl1r27Iz3FLezEKVf2jZwpcyC09X446oGAK4r6KDh6EoUqM7JZSyHJCngzKcf0tDCt8AQJ49t_vPSL38ArjH8v8OdnvNzv_AoBQb46jph-TO_P3HxfnfwCmBgoY |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3fb9MwED6NToK9INiAlZ9GQrxFbWKniXmrJqaOrRUSm9Q3y44dtTCSqE0R_AP83dw5zhAP0ySUlyi2Fct3vvtsf74DeDfJnTQJT6PYcR2JohQ0pdAY8jLVFp_YB_WZLyazK_FpmS734KS_C0O0ymD7O5vurXX4MgqjOWrW69EXOtSjvN6olOMJeq17sE_RqcQA9qdn57PFX6ZHnHZRpOgQABv0N-g8zatyOxwg4njlPuBpwm_zULchUO-JTh_BwwAh2bTr5WPYc9UhHE0rXD5__8XeM0_q9Lvlh3B_Hs7Oj-D3lCGEZoGNyZp620bbdlN_c6zR64qhKjCfF-cD0zuf1bbebZkntrN1Rds1zrJ2pa8pgz1bEUN3s0JrhIVo4n44qkUQdItv7mfg11asLtnnZCkYjrJrcIH_BK5OP16ezKKQhSEq0Lm1UYIOPbOlnBQuy8e6sIJzjTjMZoU1RsjcIMYZa20zYVHKpbRxGYtE5ybNnEM0-RQGVV25Y2CcF8YWmdF5kQuJC0OKQmqs1BYth-FuCLwfeVWEEOWUKeNa9Vy0r6qTlyJ5qbFUKK8hRDetmi5Exx31s16o6h9VU-hF7mj5ttcBhbOQjlZ05VAYKqHL3VJmMhnCs045bvrCKckXgoDn__3fN_Bgdjm_UBdni_MXcEAldB0yGb-EQbvZuVeIi1rzOuj9H7TdDMk |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+new+central+post-stroke+pain+rat+model%3A+autologous+blood+injected+thalamic+hemorrhage+involved+increased+expression+of+P2X4+receptor&rft.jtitle=Neuroscience+letters&rft.au=Lu%2C+Hai-Feng&rft.au=Xu%2C+Chun-Yang&rft.au=Zhang%2C+Lei&rft.au=Gan%2C+Lei&rft.date=2018-11-20&rft.eissn=1872-7972&rft.volume=687&rft.spage=124&rft_id=info:doi/10.1016%2Fj.neulet.2018.09.023&rft_id=info%3Apmid%2F30267847&rft.externalDocID=30267847 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0304-3940&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0304-3940&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0304-3940&client=summon |