Opioids and cancer prognosis: A summary of the clinical evidence

•Opium use is associated with an increased risk of cancer development.•Prescription opioid use have not convincingly showed to increase the risk of new cancers.•The mu opioid receptor could be used as an actionable target for the treatment of malignancies expressing the receptor. Pain is a common an...

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Published inNeuroscience letters Vol. 746; p. 135661
Main Authors Ramirez, Maria F., Gorur, A., Cata, Juan P.
Format Journal Article
LanguageEnglish
Published Ireland Elsevier B.V 16.02.2021
Subjects
Analgesics, Opioid - administration & dosage
Analgesics, Opioid - adverse effects
Animals
Biomarkers, Tumor - biosynthesis
Biomarkers, Tumor - genetics
Cancer
Cancer Pain - diagnosis
Cancer Pain - drug therapy
Cancer Pain - metabolism
Evidence-Based Medicine - methods
Humans
Mu-opioid receptors
Neoplasms - diagnosis
Neoplasms - drug therapy
Neoplasms - metabolism
Opioids
Pain Management - adverse effects
Pain Management - methods
Prognosis
Receptors, Opioid, mu - biosynthesis
Receptors, Opioid, mu - genetics
Retrospective Studies
Survival
Tumor Microenvironment - drug effects
Tumor Microenvironment - physiology
Survival
Mu-opioid receptors
Opioids
Cancer
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Abstract •Opium use is associated with an increased risk of cancer development.•Prescription opioid use have not convincingly showed to increase the risk of new cancers.•The mu opioid receptor could be used as an actionable target for the treatment of malignancies expressing the receptor. Pain is a common and devastating symptom among cancer patients. It can be caused by the cancer itself or by certain therapies like surgery, radiation or chemotherapy. Opioids are the first line of treatment for moderate to severe cancer-related pain. Opioids alone or in combination with non-opioid analgesics and adjuvant medications are important components for pain management during the perioperative period for cancer patients. Opioids act on the μ-opioid receptor (MOR), which is expressed in cancer cells and non-malignant cells of the tumor microenvironment. Retrospective studies suggest an association between the expression of MOR in cancers and shorter survival. In addition, recent evidence suggests that opium use and prescription opioids can influence clinical oncological outcomes. In this review, we will summarize the clinical evidence regarding the effect of opioid administration and survival in patients with cancer as well as the current evidence involving MOR expression and cancer progression.
AbstractList Pain is a common and devastating symptom among cancer patients. It can be caused by the cancer itself or by certain therapies like surgery, radiation or chemotherapy. Opioids are the first line of treatment for moderate to severe cancer-related pain. Opioids alone or in combination with non-opioid analgesics and adjuvant medications are important components for pain management during the perioperative period for cancer patients. Opioids act on the μ-opioid receptor (MOR), which is expressed in cancer cells and non-malignant cells of the tumor microenvironment. Retrospective studies suggest an association between the expression of MOR in cancers and shorter survival. In addition, recent evidence suggests that opium use and prescription opioids can influence clinical oncological outcomes. In this review, we will summarize the clinical evidence regarding the effect of opioid administration and survival in patients with cancer as well as the current evidence involving MOR expression and cancer progression.
•Opium use is associated with an increased risk of cancer development.•Prescription opioid use have not convincingly showed to increase the risk of new cancers.•The mu opioid receptor could be used as an actionable target for the treatment of malignancies expressing the receptor. Pain is a common and devastating symptom among cancer patients. It can be caused by the cancer itself or by certain therapies like surgery, radiation or chemotherapy. Opioids are the first line of treatment for moderate to severe cancer-related pain. Opioids alone or in combination with non-opioid analgesics and adjuvant medications are important components for pain management during the perioperative period for cancer patients. Opioids act on the μ-opioid receptor (MOR), which is expressed in cancer cells and non-malignant cells of the tumor microenvironment. Retrospective studies suggest an association between the expression of MOR in cancers and shorter survival. In addition, recent evidence suggests that opium use and prescription opioids can influence clinical oncological outcomes. In this review, we will summarize the clinical evidence regarding the effect of opioid administration and survival in patients with cancer as well as the current evidence involving MOR expression and cancer progression.
ArticleNumber 135661
Author Ramirez, Maria F.
Gorur, A.
Cata, Juan P.
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Keywords Survival
Mu-opioid receptors
Opioids
Cancer
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Snippet •Opium use is associated with an increased risk of cancer development.•Prescription opioid use have not convincingly showed to increase the risk of new...
Pain is a common and devastating symptom among cancer patients. It can be caused by the cancer itself or by certain therapies like surgery, radiation or...
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StartPage 135661
SubjectTerms Analgesics, Opioid - administration & dosage
Analgesics, Opioid - adverse effects
Animals
Biomarkers, Tumor - biosynthesis
Biomarkers, Tumor - genetics
Cancer
Cancer Pain - diagnosis
Cancer Pain - drug therapy
Cancer Pain - metabolism
Evidence-Based Medicine - methods
Humans
Mu-opioid receptors
Neoplasms - diagnosis
Neoplasms - drug therapy
Neoplasms - metabolism
Opioids
Pain Management - adverse effects
Pain Management - methods
Prognosis
Receptors, Opioid, mu - biosynthesis
Receptors, Opioid, mu - genetics
Retrospective Studies
Survival
Tumor Microenvironment - drug effects
Tumor Microenvironment - physiology
Title Opioids and cancer prognosis: A summary of the clinical evidence
URI https://dx.doi.org/10.1016/j.neulet.2021.135661
https://www.ncbi.nlm.nih.gov/pubmed/33482308
Volume 746
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