Covalent inhibition of histone deacetylase 8 by 3,4-dihydro-2H-pyrimido[1,2-c][1,3]benzothiazin-6-imine - Muth, Marius; Jänsch, Niklas; Kopranovic, Aleksandra; Krämer, Andreas; Wössner, Nathalie; Jung, Manfred; Kirschhöfer, Frank; Brenner-Weiß, Gerald; Meyer-Almes, Franz-Josef (Biochimica et biophysica acta. General subjects, 2019)
Keywords: active sites; Binding mechanism; childhood; computational methodology; Covalent inhibitor; crystal structure; Enzyme inhibition; HDAC8; histone deacetylase; Non-hydroxamate inhibitor; reaction mechanisms; reducing agents; Selective inhibition; sulfides; T-cell lymphoma; tandem mass spectrometry; therapeutics; thiocyanates; thiols; zinc; Enzyme inhibition; Non-hydroxamate inhibitor; Selective inhibition; Covalent inhibitor; HDAC8; Binding mechanism