N-(2-Hydroxyethyl)-l-valyl-l-leucine: a novel urinary biomarker of ethylene oxide exposure in humans

• Published in: Toxicology letters Vol. 326; pp. 18 - 22
• Main Authors: Mráz, Jaroslav, Hanzlíková, Iveta, Dušková, Šárka, Tvrdíková, Monika, Linhart, Igor
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.06.2020
• Subjects: Adult; Biological monitoring; Biological Monitoring - methods; Biomarkers - urine; Carcinogens - toxicity; Ethylene oxide; Ethylene Oxide - urine; Female; Globin adducts; Humans; Male; Middle Aged; Occupational exposure; Occupational Exposure - adverse effects; Urinary dipeptidic adducts; Valine - urine; Urinary dipeptidic adducts; Globin adducts; Ethylene oxide; Occupational exposure; Biological monitoring

•Novel urinary metabolite of ethylene oxide in occupationally exposed workers.•Non-invasive biomonitoring strategy to assess long-term exposures to ethylene oxide.•In vivo cleavage of ethylene oxide adduct in globin to a specific urinary dipeptide. Ethylene oxide (EO), a carcinogenic chemical used a...