Design, synthesis and antimicrobial evaluation of novel glycosylated-fluoroquinolones derivatives

• Published in: European journal of medicinal chemistry Vol. 202; pp. 112513 - 112522
• Main Authors: Mohammed, Aya A.M., Suaifan, Ghadeer A.R.Y., Shehadeh, Mayadah B., Okechukwu, Patrick N.
• Format: Journal Article
• Language: English
• Published: ISSY-LES-MOULINEAUX Elsevier Masson SAS 15.09.2020; Elsevier
• Subjects: Anti-Bacterial Agents - chemical synthesis; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Antibacterial; Antifungal; Antifungal Agents - chemical synthesis; Antifungal Agents - chemistry; Antifungal Agents - pharmacology; Candida albicans - drug effects; Chemistry, Medicinal; Ciprofloxacin; Dose-Response Relationship, Drug; Drug Design; Fluoroquinolones - chemical synthesis; Fluoroquinolones - chemistry; Fluoroquinolones - pharmacology; Glucosamine; Glycosylation; Gram-Negative Bacteria - drug effects; Gram-Positive Bacteria - drug effects; Life Sciences & Biomedicine; Microbial Sensitivity Tests; Molecular Structure; MTT assay; Penicillium chrysogenum - drug effects; Pharmacology & Pharmacy; Science & Technology; Structure-Activity Relationship; Glucosamine; Antifungal; Antibacterial; Ciprofloxacin; MTT assay; Structure-activity relationship; NORFLOXACIN; ANTIBACTERIAL ACTIVITY; TUBERCULOSIS; INDUCTION

Herein we report the design, synthesis and biological evaluation of structurally modified ciprofloxacin, norfloxacin and moxifloxacin standard drugs, featuring amide functional groups at C-3 of the fluoroquinolone scaffold. In vitro antimicrobial testing against various Gram-positive bacteria, Gram-...