Tetracycline antibiotics: Potential anticancer drugs

In recent years, research on tetracycline antibiotics has gradually shifted from their antibacterial effects to anticancer effects. Doxycycline, minocycline, and tigecycline as the US Food and Drug Administration (FDA) approved tetracycline antibiotics have been the main subjects of studies. Evidenc...

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Published inEuropean journal of pharmacology Vol. 956; p. 175949
Main Authors Li, Jiayu, Qin, Yuan, Zhao, Chenhao, Zhang, Zhi, Zhou, Zhiruo
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 05.10.2023
Subjects
Anticancer
Doxycycline
Minocycline
Tetracycline antibiotics
Tigecycline
Minocycline
Tetracycline antibiotics
Tigecycline
Anticancer
Doxycycline
Online AccessGet full text
ISSN0014-2999
1879-0712
1879-0712
DOI10.1016/j.ejphar.2023.175949

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Abstract In recent years, research on tetracycline antibiotics has gradually shifted from their antibacterial effects to anticancer effects. Doxycycline, minocycline, and tigecycline as the US Food and Drug Administration (FDA) approved tetracycline antibiotics have been the main subjects of studies. Evidence indicated that they have anticancer properties and are able to control cancer progression through different mechanisms, such as anti-proliferation, anti-metastasis, and promotion of autophagy or apoptosis. In addition, studies have shown that these three tetracycline antibiotics can be utilized in conjunction with chemotherapeutic and targeted drugs to inhibit cancer progression and improve the quality of patient survival. Therefore, doxycycline, minocycline, and tigecycline are taken as examples in this work. Their mechanisms of action in different cancers and related combination therapies are introduced. Their current roles in alleviating the suffering of patients undergoing chemotherapy when used as adjuvant drugs in clinical treatment are also described. Finally, the research gaps and potential research directions at this stage are briefly summarized.
AbstractList In recent years, research on tetracycline antibiotics has gradually shifted from their antibacterial effects to anticancer effects. Doxycycline, minocycline, and tigecycline as the US Food and Drug Administration (FDA) approved tetracycline antibiotics have been the main subjects of studies. Evidence indicated that they have anticancer properties and are able to control cancer progression through different mechanisms, such as anti-proliferation, anti-metastasis, and promotion of autophagy or apoptosis. In addition, studies have shown that these three tetracycline antibiotics can be utilized in conjunction with chemotherapeutic and targeted drugs to inhibit cancer progression and improve the quality of patient survival. Therefore, doxycycline, minocycline, and tigecycline are taken as examples in this work. Their mechanisms of action in different cancers and related combination therapies are introduced. Their current roles in alleviating the suffering of patients undergoing chemotherapy when used as adjuvant drugs in clinical treatment are also described. Finally, the research gaps and potential research directions at this stage are briefly summarized.In recent years, research on tetracycline antibiotics has gradually shifted from their antibacterial effects to anticancer effects. Doxycycline, minocycline, and tigecycline as the US Food and Drug Administration (FDA) approved tetracycline antibiotics have been the main subjects of studies. Evidence indicated that they have anticancer properties and are able to control cancer progression through different mechanisms, such as anti-proliferation, anti-metastasis, and promotion of autophagy or apoptosis. In addition, studies have shown that these three tetracycline antibiotics can be utilized in conjunction with chemotherapeutic and targeted drugs to inhibit cancer progression and improve the quality of patient survival. Therefore, doxycycline, minocycline, and tigecycline are taken as examples in this work. Their mechanisms of action in different cancers and related combination therapies are introduced. Their current roles in alleviating the suffering of patients undergoing chemotherapy when used as adjuvant drugs in clinical treatment are also described. Finally, the research gaps and potential research directions at this stage are briefly summarized.
In recent years, research on tetracycline antibiotics has gradually shifted from their antibacterial effects to anticancer effects. Doxycycline, minocycline, and tigecycline as the US Food and Drug Administration (FDA) approved tetracycline antibiotics have been the main subjects of studies. Evidence indicated that they have anticancer properties and are able to control cancer progression through different mechanisms, such as anti-proliferation, anti-metastasis, and promotion of autophagy or apoptosis. In addition, studies have shown that these three tetracycline antibiotics can be utilized in conjunction with chemotherapeutic and targeted drugs to inhibit cancer progression and improve the quality of patient survival. Therefore, doxycycline, minocycline, and tigecycline are taken as examples in this work. Their mechanisms of action in different cancers and related combination therapies are introduced. Their current roles in alleviating the suffering of patients undergoing chemotherapy when used as adjuvant drugs in clinical treatment are also described. Finally, the research gaps and potential research directions at this stage are briefly summarized.
ArticleNumber 175949
Author Li, Jiayu
Zhao, Chenhao
Qin, Yuan
Zhou, Zhiruo
Zhang, Zhi
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  surname: Qin
  fullname: Qin, Yuan
  organization: College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, China
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  givenname: Chenhao
  surname: Zhao
  fullname: Zhao, Chenhao
  organization: College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, China
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  givenname: Zhi
  surname: Zhang
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  givenname: Zhiruo
  surname: Zhou
  fullname: Zhou, Zhiruo
  email: zhouzhiruo@zjgsu.edu.cn
  organization: School of Environmental Science and Engineering, Zhejiang Gongshang University, Hangzhou, China
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Keywords Minocycline
Tetracycline antibiotics
Tigecycline
Anticancer
Doxycycline
Language English
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Snippet In recent years, research on tetracycline antibiotics has gradually shifted from their antibacterial effects to anticancer effects. Doxycycline, minocycline,...
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SubjectTerms Anticancer
Doxycycline
Minocycline
Tetracycline antibiotics
Tigecycline
Title Tetracycline antibiotics: Potential anticancer drugs
URI https://dx.doi.org/10.1016/j.ejphar.2023.175949
https://www.ncbi.nlm.nih.gov/pubmed/37541377
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