(-)-Asarinin alleviates gastric precancerous lesions by promoting mitochondrial ROS accumulation and inhibiting the STAT3 signaling pathway
(-)-Asarinin (Asarinin) is the primary component in the extract of the herb Asarum sieboldii Miq. It possesses various functions, including pain relief, anti-viral and anti-tuberculous bacilli effects, and inhibition of tumor growth. Gastric precancerous lesion (GPL) is a common but potentially carc...
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Published in | Phytomedicine (Stuttgart) Vol. 126; p. 155348 |
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Main Authors | , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
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Elsevier GmbH
01.04.2024
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Abstract | (-)-Asarinin (Asarinin) is the primary component in the extract of the herb Asarum sieboldii Miq. It possesses various functions, including pain relief, anti-viral and anti-tuberculous bacilli effects, and inhibition of tumor growth. Gastric precancerous lesion (GPL) is a common but potentially carcinogenic chronic gastrointestinal disease, and its progression can lead to gastric dysfunction and cancer development. However, the protective effects of asarinin against GPL and the underlying mechanisms remain unexplored.
A premalignant cell model (methylnitronitrosoguanidine-induced malignant transformation of human gastric epithelial cell strain, MC cells) and a GPL animal model were established and then were treated with asarinin. The cytotoxic effect of asarinin was assessed using a CCK8 assay. Detection of intracellular reactive oxygen species (ROS) using DCFH-DA. Apoptosis in MC cells was evaluated using an annexin V-FITC/PI assay. We performed western blot analysis and immunohistochemistry (IHC) to analyze relevant markers, investigating the in vitro and in vivo therapeutic effects of asarinin on GPL and its intrinsic mechanisms.
Our findings showed that asarinin inhibited MC cell proliferation, enhanced intracellular ROS levels, and induced cell apoptosis. Further investigations revealed that the pharmacological effects of asarinin on MC cells were blocked by the ROS scavenger N-acetylcysteine. IHC revealed a significant upregulation of phospho-signal transducer and activator of transcription 3 (p-STAT3) protein expression in human GPL tissues. In vitro, asarinin exerted its pro-apoptotic effects in MC cells by modulating the STAT3 signaling pathway. Agonists of STAT3 were able to abolish the effects of asarinin on MC cells. In vivo, asarinin induced ROS accumulation and inhibited the STAT3 pathway in gastric mucosa of mice, thereby halting and even reversing the development of GPL.
Asarinin induces apoptosis and delays the progression of GPL by promoting mitochondrial ROS production, decreasing mitochondrial membrane potential (MMP), and inhibiting the STAT3 pathway.
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AbstractList | (-)-Asarinin (Asarinin) is the primary component in the extract of the herb Asarum sieboldii Miq. It possesses various functions, including pain relief, anti-viral and anti-tuberculous bacilli effects, and inhibition of tumor growth. Gastric precancerous lesion (GPL) is a common but potentially carcinogenic chronic gastrointestinal disease, and its progression can lead to gastric dysfunction and cancer development. However, the protective effects of asarinin against GPL and the underlying mechanisms remain unexplored.
A premalignant cell model (methylnitronitrosoguanidine-induced malignant transformation of human gastric epithelial cell strain, MC cells) and a GPL animal model were established and then were treated with asarinin. The cytotoxic effect of asarinin was assessed using a CCK8 assay. Detection of intracellular reactive oxygen species (ROS) using DCFH-DA. Apoptosis in MC cells was evaluated using an annexin V-FITC/PI assay. We performed western blot analysis and immunohistochemistry (IHC) to analyze relevant markers, investigating the in vitro and in vivo therapeutic effects of asarinin on GPL and its intrinsic mechanisms.
Our findings showed that asarinin inhibited MC cell proliferation, enhanced intracellular ROS levels, and induced cell apoptosis. Further investigations revealed that the pharmacological effects of asarinin on MC cells were blocked by the ROS scavenger N-acetylcysteine. IHC revealed a significant upregulation of phospho-signal transducer and activator of transcription 3 (p-STAT3) protein expression in human GPL tissues. In vitro, asarinin exerted its pro-apoptotic effects in MC cells by modulating the STAT3 signaling pathway. Agonists of STAT3 were able to abolish the effects of asarinin on MC cells. In vivo, asarinin induced ROS accumulation and inhibited the STAT3 pathway in gastric mucosa of mice, thereby halting and even reversing the development of GPL.
Asarinin induces apoptosis and delays the progression of GPL by promoting mitochondrial ROS production, decreasing mitochondrial membrane potential (MMP), and inhibiting the STAT3 pathway. (-)-Asarinin (Asarinin) is the primary component in the extract of the herb Asarum sieboldii Miq. It possesses various functions, including pain relief, anti-viral and anti-tuberculous bacilli effects, and inhibition of tumor growth. Gastric precancerous lesion (GPL) is a common but potentially carcinogenic chronic gastrointestinal disease, and its progression can lead to gastric dysfunction and cancer development. However, the protective effects of asarinin against GPL and the underlying mechanisms remain unexplored. A premalignant cell model (methylnitronitrosoguanidine-induced malignant transformation of human gastric epithelial cell strain, MC cells) and a GPL animal model were established and then were treated with asarinin. The cytotoxic effect of asarinin was assessed using a CCK8 assay. Detection of intracellular reactive oxygen species (ROS) using DCFH-DA. Apoptosis in MC cells was evaluated using an annexin V-FITC/PI assay. We performed western blot analysis and immunohistochemistry (IHC) to analyze relevant markers, investigating the in vitro and in vivo therapeutic effects of asarinin on GPL and its intrinsic mechanisms. Our findings showed that asarinin inhibited MC cell proliferation, enhanced intracellular ROS levels, and induced cell apoptosis. Further investigations revealed that the pharmacological effects of asarinin on MC cells were blocked by the ROS scavenger N-acetylcysteine. IHC revealed a significant upregulation of phospho-signal transducer and activator of transcription 3 (p-STAT3) protein expression in human GPL tissues. In vitro, asarinin exerted its pro-apoptotic effects in MC cells by modulating the STAT3 signaling pathway. Agonists of STAT3 were able to abolish the effects of asarinin on MC cells. In vivo, asarinin induced ROS accumulation and inhibited the STAT3 pathway in gastric mucosa of mice, thereby halting and even reversing the development of GPL. Asarinin induces apoptosis and delays the progression of GPL by promoting mitochondrial ROS production, decreasing mitochondrial membrane potential (MMP), and inhibiting the STAT3 pathway. [Display omitted] BACKGROUND(-)-Asarinin (Asarinin) is the primary component in the extract of the herb Asarum sieboldii Miq. It possesses various functions, including pain relief, anti-viral and anti-tuberculous bacilli effects, and inhibition of tumor growth. Gastric precancerous lesion (GPL) is a common but potentially carcinogenic chronic gastrointestinal disease, and its progression can lead to gastric dysfunction and cancer development. However, the protective effects of asarinin against GPL and the underlying mechanisms remain unexplored.METHODSA premalignant cell model (methylnitronitrosoguanidine-induced malignant transformation of human gastric epithelial cell strain, MC cells) and a GPL animal model were established and then were treated with asarinin. The cytotoxic effect of asarinin was assessed using a CCK8 assay. Detection of intracellular reactive oxygen species (ROS) using DCFH-DA. Apoptosis in MC cells was evaluated using an annexin V-FITC/PI assay. We performed western blot analysis and immunohistochemistry (IHC) to analyze relevant markers, investigating the in vitro and in vivo therapeutic effects of asarinin on GPL and its intrinsic mechanisms.RESULTSOur findings showed that asarinin inhibited MC cell proliferation, enhanced intracellular ROS levels, and induced cell apoptosis. Further investigations revealed that the pharmacological effects of asarinin on MC cells were blocked by the ROS scavenger N-acetylcysteine. IHC revealed a significant upregulation of phospho-signal transducer and activator of transcription 3 (p-STAT3) protein expression in human GPL tissues. In vitro, asarinin exerted its pro-apoptotic effects in MC cells by modulating the STAT3 signaling pathway. Agonists of STAT3 were able to abolish the effects of asarinin on MC cells. In vivo, asarinin induced ROS accumulation and inhibited the STAT3 pathway in gastric mucosa of mice, thereby halting and even reversing the development of GPL.CONCLUSIONAsarinin induces apoptosis and delays the progression of GPL by promoting mitochondrial ROS production, decreasing mitochondrial membrane potential (MMP), and inhibiting the STAT3 pathway. |
ArticleNumber | 155348 |
Author | Li, Yuchen Liao, Wenhao Zhao, Ziyi Zhao, Maoyuan Pan, Huafeng Shen, Caifei Tang, Jianyuan Chen, Nianzhi Zheng, Qiao Zhang, Gang Gong, Daoyin Wen, Yueqiang Zeng, Jinhao Yang, Yi Xie, Shunkai |
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Cites_doi | 10.1002/mc.22353 10.1016/j.semcdb.2008.06.005 10.1016/j.redox.2020.101426 10.1038/ncb2468 10.3390/molecules26010092 10.1016/j.ejcb.2020.151073 10.1053/j.gastro.2019.12.010 10.1016/j.biomaterials.2021.121110 10.3322/caac.21660 10.1074/jbc.R800084200 10.1023/A:1009616228304 10.3892/mmr.2015.4650 10.1016/j.biopha.2018.09.012 10.1016/j.bpg.2016.09.004 10.6004/jnccn.2022.0008 10.1016/j.mito.2020.04.012 10.1016/j.freeradbiomed.2015.11.022 10.1152/physrev.00026.2013 10.32074/1591-951X-166 10.1101/cshperspect.a008656 10.1016/j.semcdb.2017.05.023 10.4103/wjtcm.wjtcm_72_20 10.1146/annurev-biochem-061809-121639 10.1007/s00018-020-03536-5 10.1089/ars.2017.7273 10.3892/or.2017.5503 10.1016/j.canlet.2018.05.038 10.2147/DDDT.S247958 10.1007/s10120-021-01159-8 10.1007/s12272-016-0795-8 10.1016/j.redox.2016.09.006 10.1126/science.277.5332.1630 10.1055/a-0859-1883 10.3390/molecules23081849 10.1002/bmc.5021 10.4251/wjgo.v8.i3.305 10.1016/j.freeradbiomed.2018.12.008 10.1016/j.fitote.2019.02.010 10.1016/j.tplants.2016.08.002 10.1182/blood-2007-05-087759 10.1016/j.tibs.2010.07.007 10.1038/nrc3818 10.1016/j.transproceed.2009.09.086 |
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Keywords | (-)-Asarinin Bcl-2 Gastric precancerous lesions GPL IHC STAT3 MC cell MDA mPTP DCFH-DA MMP NAC Mitochondria AB-PAS MNU ROS Bax ATP GSH MNNG |
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References | Zhang, Yu, Yang, Zhang (bib0043) 2009; 41 Chen, Hu, Zhang, Chen, Hu, Li, Liang, Cai, Hu, Wang, Huang, Tang (bib0005) 2019; 131 Crawford, Wells (bib0006) 2011; 80 Maryanovich, Oberkovitz, Niv, Vorobiyov, Zaltsman, Brenner, Lapidot, Jung, Gross (bib0024) 2012; 14 Wang, Wang, Zheng, Meng, Lyu, Jin (bib0038) 2016; 8 Hong‑Ping, Guang-Ping, Li, Chen, Gao, Song, Zhang, Ye (bib0011) 2020; 6 Jeong, Jang, Cho, Lee (bib0014) 2021; 35 Groner, Lucks, Borghouts (bib0009) 2008; 19 Chatterjee, Chatterjee (bib0003) 2020; 99 Lage, Uedo, Dinis-Ribeiro, Yao (bib0019) 2016; 30 McIlwain, Berger, Mak (bib0025) 2013; 5 Dai, Li, Wang, Li, Li (bib0007) 2020; 19 Niu, Liao, Zhou, Wen, Quan, Pan, Wu (bib0030) 2021; 277 Ni, Mei, Sun (bib0029) 2012; 59 Pop, Salvesen (bib0033) 2009; 284 Sung, Ferlay, Siegel, Laversanne, Soerjomataram, Jemal, Bray (bib0036) 2021; 71 Yu, Lee, Herrmann, Buettner, Jove (bib0042) 2014; 14 Zhang, Wu, Zhang, Mo, Lu, Wei, Chen, Lan, Lu, Liu (bib0044) 2017; 37 Li, Yang, Gu, Di (bib0023) 2019; 134 Kirtonia, Sethi, Garg (bib0018) 2020; 77 Pimentel-Nunes, Libanio, Marcos-Pinto, Areia, Leja, Esposito, Garrido, Kikuste, Megraud, Matysiak-Budnik, Annibale, Dumonceau, Barros, Flejou, Carneiro, van Hooft, Kuipers, Dinis-Ribeiro (bib0032) 2019; 51 Zhao, Peng, He, Li, Wang, Huang, Lei, Li, Ma (bib0045) 2021; 24 Chen, Zou, Zhao, Chen, Fan, Vinothkumar, Cui, Wu, Zhang, Liang, Ji (bib0004) 2016; 10 Mi, Xiao, Du, Wu, Qi, Liu (bib0026) 2016; 90 Wu, Hang, Yang, Chen, Lin, Chiang, Lu, Yang, Lai, Ko, Chung (bib0039) 2010; 30 Zorov, Juhaszova, Sollott (bib0046) 2014; 94 Ajani, D'Amico, Bentrem, Chao, Cooke, Corvera, Das, Enzinger, Enzler, Fanta, Farjah, Gerdes, Gibson, Hochwald, Hofstetter, Ilson, Keswani, Kim, Kleinberg, Klempner, Lacy, Ly, Matkowskyj, McNamara, Mulcahy, Outlaw, Park, Perry, Pimiento, Poultsides, Reznik, Roses, Strong, Su, Wang, Wiesner, Willett, Yakoub, Yoon, McMillian, Pluchino (bib0001) 2022; 20 Darnell (bib0008) 1997; 277 Gullo, Grillo, Mastracci, Vanoli, Carneiro, Saragoni, Limarzi, Ferro, Parente, Fassan (bib0010) 2020; 112 Kim, Yi, Ye (bib0015) 2016; 39 Xu, Shen, Pei, Wang, Sun, Li, Xiu, Liu, Lu, Zhang, Yue (bib0040) 2018; 108 Cai, Wang, Zhu, Zhang, Zhang, Yan, Qian, Xu (bib0002) 2016; 13 Jeong, Kim, Lee, Choi, Jang (bib0013) 2018; 23 Moloney, Cotter (bib0028) 2018; 80 Jang, Sharkis (bib0012) 2007; 110 Yang, He, Zhang, Li (bib0041) 2020; 26 Mittler (bib0027) 2017; 22 Kim, Lee, Yang, Arfuso, Um, Kumar, Bian, Sethi, Ahn (bib0016) 2018; 431 Li, Slone, Huang (bib0022) 2020; 53 Larson-Casey, He, Carter (bib0020) 2020; 33 Li, Zhao, Li, Kang, Zhang (bib0021) 2020; 14 Scherz-Shouval, Elazar (bib0034) 2011; 36 Kim, Park, Chae, Kundu, Kim, Kundu, Chun (bib0017) 2016; 55 Perusina Lanfranca, Zhang, Girgis, Kasselman, Lazarus, Kryczek, Delrosario, Rhim, Koneva, Sartor, Sun, Halbrook, Nathan, Shi, Crawford, Pasca di Magliano, Zou, Frankel (bib0031) 2020; 158 Tan, Suda (bib0037) 2018; 29 Simon, Haj-Yehia, Levi-Schaffer (bib0035) 2000; 5 Crawford (10.1016/j.phymed.2024.155348_bib0006) 2011; 80 Niu (10.1016/j.phymed.2024.155348_bib0030) 2021; 277 Perusina Lanfranca (10.1016/j.phymed.2024.155348_bib0031) 2020; 158 Li (10.1016/j.phymed.2024.155348_bib0022) 2020; 53 Zorov (10.1016/j.phymed.2024.155348_bib0046) 2014; 94 Yu (10.1016/j.phymed.2024.155348_bib0042) 2014; 14 Chen (10.1016/j.phymed.2024.155348_bib0004) 2016; 10 Chatterjee (10.1016/j.phymed.2024.155348_bib0003) 2020; 99 Lage (10.1016/j.phymed.2024.155348_bib0019) 2016; 30 Groner (10.1016/j.phymed.2024.155348_bib0009) 2008; 19 Tan (10.1016/j.phymed.2024.155348_bib0037) 2018; 29 Xu (10.1016/j.phymed.2024.155348_bib0040) 2018; 108 Zhang (10.1016/j.phymed.2024.155348_bib0043) 2009; 41 Hong‑Ping (10.1016/j.phymed.2024.155348_bib0011) 2020; 6 Zhang (10.1016/j.phymed.2024.155348_bib0044) 2017; 37 Dai (10.1016/j.phymed.2024.155348_bib0007) 2020; 19 Maryanovich (10.1016/j.phymed.2024.155348_bib0024) 2012; 14 Pimentel-Nunes (10.1016/j.phymed.2024.155348_bib0032) 2019; 51 Darnell (10.1016/j.phymed.2024.155348_bib0008) 1997; 277 Cai (10.1016/j.phymed.2024.155348_bib0002) 2016; 13 Kirtonia (10.1016/j.phymed.2024.155348_bib0018) 2020; 77 Wang (10.1016/j.phymed.2024.155348_bib0038) 2016; 8 Mi (10.1016/j.phymed.2024.155348_bib0026) 2016; 90 Sung (10.1016/j.phymed.2024.155348_bib0036) 2021; 71 Jeong (10.1016/j.phymed.2024.155348_bib0014) 2021; 35 Kim (10.1016/j.phymed.2024.155348_bib0015) 2016; 39 Jeong (10.1016/j.phymed.2024.155348_bib0013) 2018; 23 Scherz-Shouval (10.1016/j.phymed.2024.155348_bib0034) 2011; 36 Wu (10.1016/j.phymed.2024.155348_bib0039) 2010; 30 Gullo (10.1016/j.phymed.2024.155348_bib0010) 2020; 112 Li (10.1016/j.phymed.2024.155348_bib0021) 2020; 14 Yang (10.1016/j.phymed.2024.155348_bib0041) 2020; 26 Chen (10.1016/j.phymed.2024.155348_bib0005) 2019; 131 Kim (10.1016/j.phymed.2024.155348_bib0016) 2018; 431 Larson-Casey (10.1016/j.phymed.2024.155348_bib0020) 2020; 33 McIlwain (10.1016/j.phymed.2024.155348_bib0025) 2013; 5 Li (10.1016/j.phymed.2024.155348_bib0023) 2019; 134 Ajani (10.1016/j.phymed.2024.155348_bib0001) 2022; 20 Simon (10.1016/j.phymed.2024.155348_bib0035) 2000; 5 Zhao (10.1016/j.phymed.2024.155348_bib0045) 2021; 24 Kim (10.1016/j.phymed.2024.155348_bib0017) 2016; 55 Pop (10.1016/j.phymed.2024.155348_bib0033) 2009; 284 Mittler (10.1016/j.phymed.2024.155348_bib0027) 2017; 22 Jang (10.1016/j.phymed.2024.155348_bib0012) 2007; 110 Moloney (10.1016/j.phymed.2024.155348_bib0028) 2018; 80 Ni (10.1016/j.phymed.2024.155348_bib0029) 2012; 59 |
References_xml | – volume: 24 start-page: 642 year: 2021 end-page: 654 ident: bib0045 article-title: Apatinib induced ferroptosis by lipid peroxidation in gastric cancer publication-title: Gastric Cancer contributor: fullname: Ma – volume: 90 start-page: 230 year: 2016 end-page: 242 ident: bib0026 article-title: Momordin Ic couples apoptosis with autophagy in human hepatoblastoma cancer cells by reactive oxygen species (ROS)-mediated PI3K/Akt and MAPK signaling pathways publication-title: Free Radic. Biol. Med. contributor: fullname: Liu – volume: 51 start-page: 365 year: 2019 end-page: 388 ident: bib0032 article-title: Management of epithelial precancerous conditions and lesions in the stomach (MAPS II): European Society of Gastrointestinal Endoscopy (ESGE), European Helicobacter and Microbiota Study Group (EHMSG), European Society of Pathology (ESP), and Sociedade Portuguesa de Endoscopia Digestiva (SPED) guideline update 2019 publication-title: Endoscopy contributor: fullname: Dinis-Ribeiro – volume: 37 start-page: 2237 year: 2017 end-page: 2244 ident: bib0044 article-title: Paclitaxel induces apoptosis of esophageal squamous cell carcinoma cells by downregulating STAT3 phosphorylation at Ser727 publication-title: Oncol. Rep. contributor: fullname: Liu – volume: 35 start-page: e5021 year: 2021 ident: bib0014 article-title: Simultaneous determination of asarinin, beta-eudesmol, and wogonin in rats using ultraperformance liquid chromatography-tandem mass spectrometry and its application to pharmacokinetic studies following administration of standards and Gumiganghwal-tang publication-title: Biomed. Chromatogr. contributor: fullname: Lee – volume: 108 start-page: 95 year: 2018 end-page: 102 ident: bib0040 article-title: Xiao Tan He Wei Decoction reverses MNNG-induced precancerous lesions of gastric carcinoma publication-title: Biomed. Pharmacother. contributor: fullname: Yue – volume: 14 start-page: 736 year: 2014 end-page: 746 ident: bib0042 article-title: Revisiting STAT3 signalling in cancer: new and unexpected biological functions publication-title: Nat. Rev. Cancer contributor: fullname: Jove – volume: 55 start-page: 1096 year: 2016 end-page: 1110 ident: bib0017 article-title: Carnosic acid inhibits STAT3 signaling and induces apoptosis through generation of ROS in human colon cancer HCT116 cells publication-title: Mol. Carcinog. contributor: fullname: Chun – volume: 5 year: 2013 ident: bib0025 article-title: Caspase functions in cell death and disease publication-title: Cold Spring Harb. Perspect. Biol. contributor: fullname: Mak – volume: 110 start-page: 3056 year: 2007 end-page: 3063 ident: bib0012 article-title: A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche publication-title: Blood contributor: fullname: Sharkis – volume: 277 start-page: 1630 year: 1997 end-page: 1635 ident: bib0008 article-title: STATs and gene regulation publication-title: Science contributor: fullname: Darnell – volume: 80 start-page: 1055 year: 2011 end-page: 1087 ident: bib0006 article-title: Caspase substrates and cellular remodeling publication-title: Annu. Rev. Biochem. contributor: fullname: Wells – volume: 22 start-page: 11 year: 2017 end-page: 19 ident: bib0027 article-title: ROS are good publication-title: Trends Plant Sci. contributor: fullname: Mittler – volume: 41 start-page: 4328 year: 2009 end-page: 4331 ident: bib0043 article-title: Antirejection effect of Herba Asari extract in rats after cardiac allograft implantation publication-title: Transplant. Proc. contributor: fullname: Zhang – volume: 14 start-page: 535 year: 2012 end-page: 541 ident: bib0024 article-title: The ATM-BID pathway regulates quiescence and survival of haematopoietic stem cells publication-title: Nat. Cell Biol. contributor: fullname: Gross – volume: 277 year: 2021 ident: bib0030 article-title: Application of glutathione depletion in cancer therapy: enhanced ROS-based therapy, ferroptosis, and chemotherapy publication-title: Biomaterials contributor: fullname: Wu – volume: 39 start-page: 1085 year: 2016 end-page: 1099 ident: bib0015 article-title: Signal transducer and activator of transcription 3 as a therapeutic target for cancer and the tumor microenvironment publication-title: Arch. Pharm. Res. contributor: fullname: Ye – volume: 36 start-page: 30 year: 2011 end-page: 38 ident: bib0034 article-title: Regulation of autophagy by ROS: physiology and pathology publication-title: Trends Biochem. Sci. contributor: fullname: Elazar – volume: 8 start-page: 305 year: 2016 end-page: 313 ident: bib0038 article-title: Expression of p-STAT3 and vascular endothelial growth factor in MNNG-induced precancerous lesions and gastric tumors in rats publication-title: World J. Gastrointest. Oncol. contributor: fullname: Jin – volume: 23 start-page: 1849 year: 2018 ident: bib0013 article-title: (-)-Asarinin from the roots of asarum sieboldii induces apoptotic cell death via caspase activation in human ovarian cancer cells publication-title: Molecules contributor: fullname: Jang – volume: 134 start-page: 135 year: 2019 end-page: 140 ident: bib0023 article-title: Absolute configuration determination of asarinin by synchrotron radiation with crystalline sponge method publication-title: Fitoterapia contributor: fullname: Di – volume: 30 start-page: 913 year: 2016 end-page: 922 ident: bib0019 article-title: Surveillance of patients with gastric precancerous conditions publication-title: Best Pract. Res. Clin. Gastroenterol. contributor: fullname: Yao – volume: 59 start-page: 671 year: 2012 end-page: 675 ident: bib0029 article-title: Oxidative DNA damage and repair in chronic atrophic gastritis and gastric cancer publication-title: Hepatogastroenterology contributor: fullname: Sun – volume: 94 start-page: 909 year: 2014 end-page: 950 ident: bib0046 article-title: Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release publication-title: Physiol. Rev. contributor: fullname: Sollott – volume: 284 start-page: 21777 year: 2009 end-page: 21781 ident: bib0033 article-title: Human caspases: activation, specificity, and regulation publication-title: J. Biol. Chem. contributor: fullname: Salvesen – volume: 29 start-page: 149 year: 2018 end-page: 168 ident: bib0037 article-title: Reactive oxygen species and mitochondrial homeostasis as regulators of stem cell fate and function publication-title: Antioxid. Redox Signal. contributor: fullname: Suda – volume: 80 start-page: 50 year: 2018 end-page: 64 ident: bib0028 article-title: ROS signalling in the biology of cancer publication-title: Semin. Cell Dev. Biol. contributor: fullname: Cotter – volume: 26 year: 2020 ident: bib0041 article-title: Natural products targeting the mitochondria in cancers publication-title: Molecules. contributor: fullname: Li – volume: 20 start-page: 167 year: 2022 end-page: 192 ident: bib0001 article-title: Gastric Cancer, Version 2.2022, NCCN Clinical Practice Guidelines in Oncology publication-title: J. Natl. Compr. Cancer Netw. contributor: fullname: Pluchino – volume: 112 start-page: 166 year: 2020 end-page: 185 ident: bib0010 article-title: Precancerous lesions of the stomach, gastric cancer and hereditary gastric cancer syndromes publication-title: Pathologica contributor: fullname: Fassan – volume: 77 start-page: 4459 year: 2020 end-page: 4483 ident: bib0018 article-title: The multifaceted role of reactive oxygen species in tumorigenesis publication-title: Cell. Mol. Life Sci. contributor: fullname: Garg – volume: 53 start-page: 38 year: 2020 end-page: 47 ident: bib0022 article-title: The role of mitochondrial-related nuclear genes in age-related common disease publication-title: Mitochondrion contributor: fullname: Huang – volume: 5 start-page: 415 year: 2000 end-page: 418 ident: bib0035 article-title: Role of reactive oxygen species (ROS) in apoptosis induction publication-title: Apoptosis contributor: fullname: Levi-Schaffer – volume: 19 start-page: 3009 year: 2020 end-page: 3016 ident: bib0007 article-title: TlR2 and TlR4 are involved in the treatment of rheumatoid arthritis synovial fibroblasts with a medicated serum of asarinin through inhibition of Th1/Th17 cytokines publication-title: Exp. Ther. Med. contributor: fullname: Li – volume: 33 year: 2020 ident: bib0020 article-title: Mitochondrial quality control in pulmonary fibrosis publication-title: Redox Biol. contributor: fullname: Carter – volume: 158 start-page: 1417 year: 2020 end-page: 1432 ident: bib0031 article-title: Interleukin 22 signaling regulates acinar cell plasticity to promote pancreatic tumor development in mice publication-title: Gastroenterology contributor: fullname: Frankel – volume: 10 start-page: 78 year: 2016 end-page: 89 ident: bib0004 article-title: Synergistic antitumor activity of rapamycin and EF24 via increasing ROS for the treatment of gastric cancer publication-title: Redox Biol. contributor: fullname: Ji – volume: 14 start-page: 2207 year: 2020 end-page: 2219 ident: bib0021 article-title: Gastro-protective effects of calycosin against precancerous lesions of gastric carcinoma in rats publication-title: Drug Des. Dev. Ther. contributor: fullname: Zhang – volume: 71 start-page: 209 year: 2021 end-page: 249 ident: bib0036 article-title: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries publication-title: CA Cancer J. Clin. contributor: fullname: Bray – volume: 6 start-page: 461 year: 2020 end-page: 468 ident: bib0011 article-title: Mitochondria are main targets of time/dose‑dependent oxidative damage‑based hepatotoxicity caused by rhizoma dioscoreae bulbiferae in mice publication-title: World J. Tradit. Chin. Med. contributor: fullname: Ye – volume: 30 start-page: 2125 year: 2010 end-page: 2133 ident: bib0039 article-title: Curcumin induces apoptosis in human non-small cell lung cancer NCI-H460 cells through ER stress and caspase cascade- and mitochondria-dependent pathways publication-title: Anticancer Res. contributor: fullname: Chung – volume: 19 start-page: 341 year: 2008 end-page: 350 ident: bib0009 article-title: The function of Stat3 in tumor cells and their microenvironment publication-title: Semin. Cell Dev. Biol. contributor: fullname: Borghouts – volume: 431 start-page: 123 year: 2018 end-page: 141 ident: bib0016 article-title: Formononetin-induced oxidative stress abrogates the activation of STAT3/5 signaling axis and suppresses the tumor growth in multiple myeloma preclinical model publication-title: Cancer Lett. contributor: fullname: Ahn – volume: 13 start-page: 1083 year: 2016 end-page: 1090 ident: bib0002 article-title: N-methyl-N-nitro-N'-nitrosoguanidine induces the expression of CCR2 in human gastric epithelial cells promoting CCL2-mediated migration publication-title: Mol. Med. Rep. contributor: fullname: Xu – volume: 99 year: 2020 ident: bib0003 article-title: ROS and oncogenesis with special reference to EMT and stemness publication-title: Eur. J. Cell Biol. contributor: fullname: Chatterjee – volume: 131 start-page: 225 year: 2019 end-page: 236 ident: bib0005 article-title: Cisplatin induces autophagy to enhance hepatitis B virus replication via activation of ROS/JNK and inhibition of the Akt/mTOR pathway publication-title: Free Radic. Biol. Med. contributor: fullname: Tang – volume: 55 start-page: 1096 year: 2016 ident: 10.1016/j.phymed.2024.155348_bib0017 article-title: Carnosic acid inhibits STAT3 signaling and induces apoptosis through generation of ROS in human colon cancer HCT116 cells publication-title: Mol. Carcinog. doi: 10.1002/mc.22353 contributor: fullname: Kim – volume: 19 start-page: 341 year: 2008 ident: 10.1016/j.phymed.2024.155348_bib0009 article-title: The function of Stat3 in tumor cells and their microenvironment publication-title: Semin. Cell Dev. Biol. doi: 10.1016/j.semcdb.2008.06.005 contributor: fullname: Groner – volume: 33 year: 2020 ident: 10.1016/j.phymed.2024.155348_bib0020 article-title: Mitochondrial quality control in pulmonary fibrosis publication-title: Redox Biol. doi: 10.1016/j.redox.2020.101426 contributor: fullname: Larson-Casey – volume: 14 start-page: 535 year: 2012 ident: 10.1016/j.phymed.2024.155348_bib0024 article-title: The ATM-BID pathway regulates quiescence and survival of haematopoietic stem cells publication-title: Nat. Cell Biol. doi: 10.1038/ncb2468 contributor: fullname: Maryanovich – volume: 26 year: 2020 ident: 10.1016/j.phymed.2024.155348_bib0041 article-title: Natural products targeting the mitochondria in cancers publication-title: Molecules. doi: 10.3390/molecules26010092 contributor: fullname: Yang – volume: 99 year: 2020 ident: 10.1016/j.phymed.2024.155348_bib0003 article-title: ROS and oncogenesis with special reference to EMT and stemness publication-title: Eur. J. Cell Biol. doi: 10.1016/j.ejcb.2020.151073 contributor: fullname: Chatterjee – volume: 158 start-page: 1417 year: 2020 ident: 10.1016/j.phymed.2024.155348_bib0031 article-title: Interleukin 22 signaling regulates acinar cell plasticity to promote pancreatic tumor development in mice publication-title: Gastroenterology doi: 10.1053/j.gastro.2019.12.010 contributor: fullname: Perusina Lanfranca – volume: 277 year: 2021 ident: 10.1016/j.phymed.2024.155348_bib0030 article-title: Application of glutathione depletion in cancer therapy: enhanced ROS-based therapy, ferroptosis, and chemotherapy publication-title: Biomaterials doi: 10.1016/j.biomaterials.2021.121110 contributor: fullname: Niu – volume: 71 start-page: 209 year: 2021 ident: 10.1016/j.phymed.2024.155348_bib0036 article-title: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries publication-title: CA Cancer J. Clin. doi: 10.3322/caac.21660 contributor: fullname: Sung – volume: 284 start-page: 21777 year: 2009 ident: 10.1016/j.phymed.2024.155348_bib0033 article-title: Human caspases: activation, specificity, and regulation publication-title: J. Biol. Chem. doi: 10.1074/jbc.R800084200 contributor: fullname: Pop – volume: 5 start-page: 415 year: 2000 ident: 10.1016/j.phymed.2024.155348_bib0035 article-title: Role of reactive oxygen species (ROS) in apoptosis induction publication-title: Apoptosis doi: 10.1023/A:1009616228304 contributor: fullname: Simon – volume: 13 start-page: 1083 year: 2016 ident: 10.1016/j.phymed.2024.155348_bib0002 article-title: N-methyl-N-nitro-N'-nitrosoguanidine induces the expression of CCR2 in human gastric epithelial cells promoting CCL2-mediated migration publication-title: Mol. Med. Rep. doi: 10.3892/mmr.2015.4650 contributor: fullname: Cai – volume: 108 start-page: 95 year: 2018 ident: 10.1016/j.phymed.2024.155348_bib0040 article-title: Xiao Tan He Wei Decoction reverses MNNG-induced precancerous lesions of gastric carcinoma in vivo and vitro: regulation of apoptosis through NF-kappaB pathway publication-title: Biomed. Pharmacother. doi: 10.1016/j.biopha.2018.09.012 contributor: fullname: Xu – volume: 59 start-page: 671 year: 2012 ident: 10.1016/j.phymed.2024.155348_bib0029 article-title: Oxidative DNA damage and repair in chronic atrophic gastritis and gastric cancer publication-title: Hepatogastroenterology contributor: fullname: Ni – volume: 30 start-page: 913 year: 2016 ident: 10.1016/j.phymed.2024.155348_bib0019 article-title: Surveillance of patients with gastric precancerous conditions publication-title: Best Pract. Res. Clin. Gastroenterol. doi: 10.1016/j.bpg.2016.09.004 contributor: fullname: Lage – volume: 20 start-page: 167 year: 2022 ident: 10.1016/j.phymed.2024.155348_bib0001 article-title: Gastric Cancer, Version 2.2022, NCCN Clinical Practice Guidelines in Oncology publication-title: J. Natl. Compr. Cancer Netw. doi: 10.6004/jnccn.2022.0008 contributor: fullname: Ajani – volume: 53 start-page: 38 year: 2020 ident: 10.1016/j.phymed.2024.155348_bib0022 article-title: The role of mitochondrial-related nuclear genes in age-related common disease publication-title: Mitochondrion doi: 10.1016/j.mito.2020.04.012 contributor: fullname: Li – volume: 90 start-page: 230 year: 2016 ident: 10.1016/j.phymed.2024.155348_bib0026 article-title: Momordin Ic couples apoptosis with autophagy in human hepatoblastoma cancer cells by reactive oxygen species (ROS)-mediated PI3K/Akt and MAPK signaling pathways publication-title: Free Radic. Biol. Med. doi: 10.1016/j.freeradbiomed.2015.11.022 contributor: fullname: Mi – volume: 94 start-page: 909 year: 2014 ident: 10.1016/j.phymed.2024.155348_bib0046 article-title: Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release publication-title: Physiol. Rev. doi: 10.1152/physrev.00026.2013 contributor: fullname: Zorov – volume: 19 start-page: 3009 year: 2020 ident: 10.1016/j.phymed.2024.155348_bib0007 article-title: TlR2 and TlR4 are involved in the treatment of rheumatoid arthritis synovial fibroblasts with a medicated serum of asarinin through inhibition of Th1/Th17 cytokines publication-title: Exp. Ther. Med. contributor: fullname: Dai – volume: 112 start-page: 166 year: 2020 ident: 10.1016/j.phymed.2024.155348_bib0010 article-title: Precancerous lesions of the stomach, gastric cancer and hereditary gastric cancer syndromes publication-title: Pathologica doi: 10.32074/1591-951X-166 contributor: fullname: Gullo – volume: 5 year: 2013 ident: 10.1016/j.phymed.2024.155348_bib0025 article-title: Caspase functions in cell death and disease publication-title: Cold Spring Harb. Perspect. Biol. doi: 10.1101/cshperspect.a008656 contributor: fullname: McIlwain – volume: 80 start-page: 50 year: 2018 ident: 10.1016/j.phymed.2024.155348_bib0028 article-title: ROS signalling in the biology of cancer publication-title: Semin. Cell Dev. Biol. doi: 10.1016/j.semcdb.2017.05.023 contributor: fullname: Moloney – volume: 6 start-page: 461 year: 2020 ident: 10.1016/j.phymed.2024.155348_bib0011 article-title: Mitochondria are main targets of time/dose‑dependent oxidative damage‑based hepatotoxicity caused by rhizoma dioscoreae bulbiferae in mice publication-title: World J. Tradit. Chin. Med. doi: 10.4103/wjtcm.wjtcm_72_20 contributor: fullname: Hong‑Ping – volume: 80 start-page: 1055 year: 2011 ident: 10.1016/j.phymed.2024.155348_bib0006 article-title: Caspase substrates and cellular remodeling publication-title: Annu. Rev. Biochem. doi: 10.1146/annurev-biochem-061809-121639 contributor: fullname: Crawford – volume: 77 start-page: 4459 year: 2020 ident: 10.1016/j.phymed.2024.155348_bib0018 article-title: The multifaceted role of reactive oxygen species in tumorigenesis publication-title: Cell. Mol. Life Sci. doi: 10.1007/s00018-020-03536-5 contributor: fullname: Kirtonia – volume: 29 start-page: 149 year: 2018 ident: 10.1016/j.phymed.2024.155348_bib0037 article-title: Reactive oxygen species and mitochondrial homeostasis as regulators of stem cell fate and function publication-title: Antioxid. Redox Signal. doi: 10.1089/ars.2017.7273 contributor: fullname: Tan – volume: 37 start-page: 2237 year: 2017 ident: 10.1016/j.phymed.2024.155348_bib0044 article-title: Paclitaxel induces apoptosis of esophageal squamous cell carcinoma cells by downregulating STAT3 phosphorylation at Ser727 publication-title: Oncol. Rep. doi: 10.3892/or.2017.5503 contributor: fullname: Zhang – volume: 431 start-page: 123 year: 2018 ident: 10.1016/j.phymed.2024.155348_bib0016 article-title: Formononetin-induced oxidative stress abrogates the activation of STAT3/5 signaling axis and suppresses the tumor growth in multiple myeloma preclinical model publication-title: Cancer Lett. doi: 10.1016/j.canlet.2018.05.038 contributor: fullname: Kim – volume: 14 start-page: 2207 year: 2020 ident: 10.1016/j.phymed.2024.155348_bib0021 article-title: Gastro-protective effects of calycosin against precancerous lesions of gastric carcinoma in rats publication-title: Drug Des. Dev. Ther. doi: 10.2147/DDDT.S247958 contributor: fullname: Li – volume: 24 start-page: 642 year: 2021 ident: 10.1016/j.phymed.2024.155348_bib0045 article-title: Apatinib induced ferroptosis by lipid peroxidation in gastric cancer publication-title: Gastric Cancer doi: 10.1007/s10120-021-01159-8 contributor: fullname: Zhao – volume: 39 start-page: 1085 year: 2016 ident: 10.1016/j.phymed.2024.155348_bib0015 article-title: Signal transducer and activator of transcription 3 as a therapeutic target for cancer and the tumor microenvironment publication-title: Arch. Pharm. Res. doi: 10.1007/s12272-016-0795-8 contributor: fullname: Kim – volume: 10 start-page: 78 year: 2016 ident: 10.1016/j.phymed.2024.155348_bib0004 article-title: Synergistic antitumor activity of rapamycin and EF24 via increasing ROS for the treatment of gastric cancer publication-title: Redox Biol. doi: 10.1016/j.redox.2016.09.006 contributor: fullname: Chen – volume: 277 start-page: 1630 year: 1997 ident: 10.1016/j.phymed.2024.155348_bib0008 article-title: STATs and gene regulation publication-title: Science doi: 10.1126/science.277.5332.1630 contributor: fullname: Darnell – volume: 51 start-page: 365 year: 2019 ident: 10.1016/j.phymed.2024.155348_bib0032 publication-title: Endoscopy doi: 10.1055/a-0859-1883 contributor: fullname: Pimentel-Nunes – volume: 23 start-page: 1849 issue: 8 year: 2018 ident: 10.1016/j.phymed.2024.155348_bib0013 article-title: (-)-Asarinin from the roots of asarum sieboldii induces apoptotic cell death via caspase activation in human ovarian cancer cells publication-title: Molecules doi: 10.3390/molecules23081849 contributor: fullname: Jeong – volume: 35 start-page: e5021 year: 2021 ident: 10.1016/j.phymed.2024.155348_bib0014 article-title: Simultaneous determination of asarinin, beta-eudesmol, and wogonin in rats using ultraperformance liquid chromatography-tandem mass spectrometry and its application to pharmacokinetic studies following administration of standards and Gumiganghwal-tang publication-title: Biomed. Chromatogr. doi: 10.1002/bmc.5021 contributor: fullname: Jeong – volume: 8 start-page: 305 year: 2016 ident: 10.1016/j.phymed.2024.155348_bib0038 article-title: Expression of p-STAT3 and vascular endothelial growth factor in MNNG-induced precancerous lesions and gastric tumors in rats publication-title: World J. Gastrointest. Oncol. doi: 10.4251/wjgo.v8.i3.305 contributor: fullname: Wang – volume: 131 start-page: 225 year: 2019 ident: 10.1016/j.phymed.2024.155348_bib0005 article-title: Cisplatin induces autophagy to enhance hepatitis B virus replication via activation of ROS/JNK and inhibition of the Akt/mTOR pathway publication-title: Free Radic. Biol. Med. doi: 10.1016/j.freeradbiomed.2018.12.008 contributor: fullname: Chen – volume: 30 start-page: 2125 year: 2010 ident: 10.1016/j.phymed.2024.155348_bib0039 article-title: Curcumin induces apoptosis in human non-small cell lung cancer NCI-H460 cells through ER stress and caspase cascade- and mitochondria-dependent pathways publication-title: Anticancer Res. contributor: fullname: Wu – volume: 134 start-page: 135 year: 2019 ident: 10.1016/j.phymed.2024.155348_bib0023 article-title: Absolute configuration determination of asarinin by synchrotron radiation with crystalline sponge method publication-title: Fitoterapia doi: 10.1016/j.fitote.2019.02.010 contributor: fullname: Li – volume: 22 start-page: 11 year: 2017 ident: 10.1016/j.phymed.2024.155348_bib0027 article-title: ROS are good publication-title: Trends Plant Sci. doi: 10.1016/j.tplants.2016.08.002 contributor: fullname: Mittler – volume: 110 start-page: 3056 year: 2007 ident: 10.1016/j.phymed.2024.155348_bib0012 article-title: A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche publication-title: Blood doi: 10.1182/blood-2007-05-087759 contributor: fullname: Jang – volume: 36 start-page: 30 year: 2011 ident: 10.1016/j.phymed.2024.155348_bib0034 article-title: Regulation of autophagy by ROS: physiology and pathology publication-title: Trends Biochem. Sci. doi: 10.1016/j.tibs.2010.07.007 contributor: fullname: Scherz-Shouval – volume: 14 start-page: 736 year: 2014 ident: 10.1016/j.phymed.2024.155348_bib0042 article-title: Revisiting STAT3 signalling in cancer: new and unexpected biological functions publication-title: Nat. Rev. Cancer doi: 10.1038/nrc3818 contributor: fullname: Yu – volume: 41 start-page: 4328 year: 2009 ident: 10.1016/j.phymed.2024.155348_bib0043 article-title: Antirejection effect of Herba Asari extract in rats after cardiac allograft implantation publication-title: Transplant. Proc. doi: 10.1016/j.transproceed.2009.09.086 contributor: fullname: Zhang |
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Snippet | (-)-Asarinin (Asarinin) is the primary component in the extract of the herb Asarum sieboldii Miq. It possesses various functions, including pain relief,... BACKGROUND(-)-Asarinin (Asarinin) is the primary component in the extract of the herb Asarum sieboldii Miq. It possesses various functions, including pain... |
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SubjectTerms | (-)-Asarinin Gastric precancerous lesions Mitochondria ROS STAT3 |
Title | (-)-Asarinin alleviates gastric precancerous lesions by promoting mitochondrial ROS accumulation and inhibiting the STAT3 signaling pathway |
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