Aminoadamantanes containing monoterpene-derived fragments as potent tyrosyl-DNA phosphodiesterase 1 inhibitors - Ponomarev, Konstantin Yu; Suslov, Evgeniy V.; Zakharenko, Alexandra L.; Zakharova, Olga D.; Rogachev, Artem D.; Korchagina, Dina V.; Zafar, Ayesha; Reynisson, Jóhannes; Nefedov, Andrey A.; Volcho, Konstantin P.; Salakhutdinov, Nariman F.; Lavrik, Olga I. (Bioorganic chemistry, 2018)
Keywords: Adamantane - analogs & derivatives; Adamantane - chemical synthesis; Adamantane - chemistry; Adamantane - pharmacology; Adamantanes; Amine; Amines - chemical synthesis; Amines - chemistry; Amines - pharmacology; Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Binding Sites; Biochemistry & Molecular Biology; Chemical space; Chemistry; Chemistry, Organic; Cytotoxicity; Drug Screening Assays, Antitumor; Drug Synergism; Fluorescent assay; HCT116 Cells; Humans; Life Sciences & Biomedicine; Molecular Docking Simulation; Monoterpenes - chemical synthesis; Monoterpenes - chemistry; Monoterpenes - pharmacology; Natural products; Phosphodiesterase Inhibitors - chemical synthesis; Phosphodiesterase Inhibitors - chemistry; Phosphodiesterase Inhibitors - pharmacology; Phosphoric Diester Hydrolases - chemistry; Phosphoric Diester Hydrolases - metabolism; Physical Sciences; Science & Technology; Stereoisomerism; Tdp1, molecular modelling; Topotecan - pharmacology; CXTYQHBRDVJROL-UHEPKEFZSA-N; Chemical space; Adamantanes; Amine; XNQOUINXDUSWSQ-UHFFFAOYSA-N; Natural products; Tdp1, molecular modelling; Cytotoxicity; Fluorescent assay; 2-AMINOADAMANTANE DERIVATIVES; EMPIRICAL SCORING FUNCTIONS; CAMPTOTHECINS; TOPOISOMERASE-I; CANCER; PROTEIN-LIGAND DOCKING; DATA-BANK; BIOLOGICAL EVALUATION; ADAMANTANE DERIVATIVES; TDP1 INHIBITORS