Delayed pulmonary toxicity syndrome following high-dose chemotherapy and bone marrow transplantation for breast cancer

• Published in: American journal of respiratory and critical care medicine Vol. 157; no. 2; pp. 565 - 573
• Main Authors: WILCZYNSKI, S. W, ERASMUS, J. J, PETROS, W. P, VREDENBURGH, J. J, FOLZ, R. J
• Format: Journal Article
• Language: English
• Published: New York, NY American Lung Association 01.02.1998
• Subjects: Adult; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Antineoplastic Combined Chemotherapy Protocols - administration & dosage; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Biological and medical sciences; Bone Marrow Transplantation; Bone marrow, stem cells transplantation. Graft versus host reaction; Breast Neoplasms - physiopathology; Breast Neoplasms - radiotherapy; Breast Neoplasms - therapy; Combined Modality Therapy - adverse effects; Dose-Response Relationship, Drug; Female; Humans; Infection - etiology; Lung - drug effects; Lung - physiopathology; Lung - radiation effects; Medical sciences; Middle Aged; Radiography, Thoracic; Respiratory Function Tests; Retrospective Studies; Steroids - therapeutic use; Tomography, X-Ray Computed; Transfusions. Complications. Transfusion reactions. Cell and gene therapy; Human; Antineoplastic agent; Lung disease; Spirometry; Radiodiagnosis; Respiratory disease; Malignant tumor; Mammary gland diseases; Chemotherapy; Autograft; Polychemotherapy; Bone marrow; Interstitial pneumonitis; Delayed toxicity; Complication; Graft; Medical imagery; Adult; Female; Computerized axial tomography; Combined treatment; Mammary gland; High dose

We have intensely followed 45 consecutive women who underwent high-dose chemotherapy (cyclophosphamide/cisplatin/BCNU) and autologous bone marrow transplant (HDC/ABMT) for primary breast cancer with pulmonary function testing and computed tomography at regular intervals up to 126 wk (median follow-u...