Delayed pulmonary toxicity syndrome following high-dose chemotherapy and bone marrow transplantation for breast cancer
We have intensely followed 45 consecutive women who underwent high-dose chemotherapy (cyclophosphamide/cisplatin/BCNU) and autologous bone marrow transplant (HDC/ABMT) for primary breast cancer with pulmonary function testing and computed tomography at regular intervals up to 126 wk (median follow-u...
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Published in | American journal of respiratory and critical care medicine Vol. 157; no. 2; pp. 565 - 573 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
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New York, NY
American Lung Association
01.02.1998
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Abstract | We have intensely followed 45 consecutive women who underwent high-dose chemotherapy (cyclophosphamide/cisplatin/BCNU) and autologous bone marrow transplant (HDC/ABMT) for primary breast cancer with pulmonary function testing and computed tomography at regular intervals up to 126 wk (median follow-up, 72 wk). Our results show a high incidence of interstitial pneumonitis requiring steroids (64%), but no deaths due to pulmonary toxicity. The DL(CO) reaches a nadir of 58.2 +/- SEM 3.4 (expressed as a percent of baseline value) 15-18 wk following HDC/ABMT, and marginally improves with time. To a much lesser extent, vital capacity is reduced with a parallel drop in FEV1, suggesting mild restrictive changes without significant obstruction. Patients who develop pulmonary symptoms of cough or dyspnea have a corresponding significantly greater and earlier decline in DL(CO). Chest computed tomography was neither sensitive nor specific for diagnosing pulmonary toxicity. For patients who received steroids for pulmonary toxicity, there was a subsequent improvement in DL(CO) of 17.1% (p = 0.0001). Because our patients do not fit with the recent definition of idiopathic pulmonary syndrome (IPS), we propose the term delayed pulmonary toxicity syndrome (DPTS) to better describe the milder form of lung toxicity seen in our patient population. We were unable to correlate the severity of DPTS with age, tobacco use, baseline pulmonary function, or systemic exposure to BCNU, cyclophosphamide, or cisplatin. These data suggest that factor(s) other than, or in addition to, chemotherapy systemic exposure can contribute to DPTS. Furthermore, early identification and institution of systemic corticosteroids may improve lung function. |
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AbstractList | We have intensely followed 45 consecutive women who underwent high-dose chemotherapy (cyclophosphamide/cisplatin/BCNU) and autologous bone marrow transplant (HDC/ABMT) for primary breast cancer with pulmonary function testing and computed tomography at regular intervals up to 126 wk (median follow-up, 72 wk). Our results show a high incidence of interstitial pneumonitis requiring steroids (64%), but no deaths due to pulmonary toxicity. The DL sub(CO) reaches a nadir of 58.2 plus or minus SEM 3.4 (expressed as a percent of baseline value) 15-18 wk following HDC/ABMT, and marginally improves with time. To a much lesser extent, vital capacity is reduced with a parallel drop in FEV sub(1), suggesting mild restrictive changes without significant obstruction. Patients who develop pulmonary symptoms of cough or dyspnea have a corresponding significantly greater and earlier decline in DL sub(CO). Chest computed tomography was neither sensitive nor specific for diagnosing pulmonary toxicity. For patients who received steroids for pulmonary toxicity, there was a subsequent improvement in DL sub(CO) of 17.1% (p = 0.0001). Because our patients do not fit with the recent definition of idiopathic pulmonary syndrome (IPS), we propose the term delayed pulmonary toxicity syndrome (DPTS) to better describe the milder form of lung toxicity seen in our patient population. We were unable to correlate the severity of DPTS with age, tobacco use, baseline pulmonary function, or systemic exposure to BCNU, cyclophosphamide, or cisplatin. These data suggest that factor(s) other than, or in addition to, chemotherapy systemic exposure can contribute to DPTS. Furthermore, early identification and institution of systemic corticosteroids may improve lung function. We have intensely followed 45 consecutive women who underwent high-dose chemotherapy (cyclophosphamide/cisplatin/BCNU) and autologous bone marrow transplant (HDC/ABMT) for primary breast cancer with pulmonary function testing and computed tomography at regular intervals up to 126 wk (median follow-up, 72 wk). Our results show a high incidence of interstitial pneumonitis requiring steroids (64%), but no deaths due to pulmonary toxicity. The DL(CO) reaches a nadir of 58.2 +/- SEM 3.4 (expressed as a percent of baseline value) 15-18 wk following HDC/ABMT, and marginally improves with time. To a much lesser extent, vital capacity is reduced with a parallel drop in FEV1, suggesting mild restrictive changes without significant obstruction. Patients who develop pulmonary symptoms of cough or dyspnea have a corresponding significantly greater and earlier decline in DL(CO). Chest computed tomography was neither sensitive nor specific for diagnosing pulmonary toxicity. For patients who received steroids for pulmonary toxicity, there was a subsequent improvement in DL(CO) of 17.1% (p = 0.0001). Because our patients do not fit with the recent definition of idiopathic pulmonary syndrome (IPS), we propose the term delayed pulmonary toxicity syndrome (DPTS) to better describe the milder form of lung toxicity seen in our patient population. We were unable to correlate the severity of DPTS with age, tobacco use, baseline pulmonary function, or systemic exposure to BCNU, cyclophosphamide, or cisplatin. These data suggest that factor(s) other than, or in addition to, chemotherapy systemic exposure can contribute to DPTS. Furthermore, early identification and institution of systemic corticosteroids may improve lung function. |
Author | FOLZ, R. J WILCZYNSKI, S. W VREDENBURGH, J. J PETROS, W. P ERASMUS, J. J |
Author_xml | – sequence: 1 givenname: S. W surname: WILCZYNSKI fullname: WILCZYNSKI, S. W organization: Departments of Medicine, Radiology, and Cell Biology, Duke University Medical Center, Durham, North Carolina, United States – sequence: 2 givenname: J. J surname: ERASMUS fullname: ERASMUS, J. J organization: Departments of Medicine, Radiology, and Cell Biology, Duke University Medical Center, Durham, North Carolina, United States – sequence: 3 givenname: W. P surname: PETROS fullname: PETROS, W. P organization: Departments of Medicine, Radiology, and Cell Biology, Duke University Medical Center, Durham, North Carolina, United States – sequence: 4 givenname: J. J surname: VREDENBURGH fullname: VREDENBURGH, J. J organization: Departments of Medicine, Radiology, and Cell Biology, Duke University Medical Center, Durham, North Carolina, United States – sequence: 5 givenname: R. J surname: FOLZ fullname: FOLZ, R. J organization: Departments of Medicine, Radiology, and Cell Biology, Duke University Medical Center, Durham, North Carolina, United States |
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Keywords | Human Antineoplastic agent Lung disease Spirometry Radiodiagnosis Respiratory disease Malignant tumor Mammary gland diseases Chemotherapy Autograft Polychemotherapy Bone marrow Interstitial pneumonitis Delayed toxicity Complication Graft Medical imagery Adult Female Computerized axial tomography Combined treatment Mammary gland High dose |
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SubjectTerms | Adult Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Bone Marrow Transplantation Bone marrow, stem cells transplantation. Graft versus host reaction Breast Neoplasms - physiopathology Breast Neoplasms - radiotherapy Breast Neoplasms - therapy Combined Modality Therapy - adverse effects Dose-Response Relationship, Drug Female Humans Infection - etiology Lung - drug effects Lung - physiopathology Lung - radiation effects Medical sciences Middle Aged Radiography, Thoracic Respiratory Function Tests Retrospective Studies Steroids - therapeutic use Tomography, X-Ray Computed Transfusions. Complications. Transfusion reactions. Cell and gene therapy |
Title | Delayed pulmonary toxicity syndrome following high-dose chemotherapy and bone marrow transplantation for breast cancer |
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